Results 41 to 50 of about 3,965 (209)

Component-specific reduction in perineuronal nets in senescence-accelerated mouse strains

IBRO Neuroscience Reports, 2023
With increased life expectancy, age-related diseases are a significant health concern in Western societies. Animal models (e.g., rodents) have been used to understand age-related changes in brain function—particularly through the senescence-accelerated ...
Hiroshi Ueno, Yu Takahashi, Shinji Murakami, Kenta Wani, Tetsuji Miyazaki, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara   +7 more
doaj   +1 more source

Proteoglycans in Perineuronal Nets.

ACTA HISTOCHEMICA ET CYTOCHEMICA, 1999
Proteoglycans are one of the major constituents of the extracellular matrix and cell membranes. In the brain, there are two major proteoglycans, chondroitin sulfate proteoglycans and heparan sulfate proteoglycans. In the adult mammalian central nervous system, some species of chondroitin sulfate proteoglycan are localized in the ‘perineuronal net ...
Matsui, Fumiko, Nishizuka, Masako, Oohira, Atsuhiko   +2 more
openaire   +2 more sources

Perineuronal nets affect memory and learning after synapse withdrawal

Translational Psychiatry, 2022
Perineuronal nets (PNNs) enwrap mature neurons, playing a role in the control of plasticity and synapse dynamics. PNNs have been shown to have effects on memory formation, retention and extinction in a variety of animal models.
Jiri Ruzicka, Marketa Dalecka, Kristyna Safrankova, Diego Peretti, Pavla Jendelova, Jessica C. F. Kwok, James W. Fawcett   +6 more
doaj   +1 more source

Regulation of the E/I-balance by the neural matrisome

Frontiers in Molecular Neuroscience, 2023
In the mammalian cortex a proper excitatory/inhibitory (E/I) balance is fundamental for cognitive functions. Especially γ-aminobutyric acid (GABA)-releasing interneurons regulate the activity of excitatory projection neurons which form the second main ...
Cornelius Mueller-Buehl, David Wegrzyn, Juliane Bauch, Andreas Faissner   +3 more
doaj   +1 more source

Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity [PDF]

The Journal of Neuroscience, 2016
Perineuronal nets (PNNs) are unique extracellular matrix structures that wrap around certain neurons in the CNS during development and control plasticity in the adult CNS. They appear to contribute to a wide range of diseases/disorders of the brain, are involved in recovery from spinal cord injury, and are altered during aging, learning and memory, and
Sorg, Barbara A, Berretta, Sabina, Blacktop, Jordan M, Fawcett, James W, Kitagawa, Hiroshi, Kwok, Jessica CF, Miquel, Marta   +6 more
openaire   +6 more sources

Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy

Nature Communications, 2018
Brain tumours are associated with epilepsy. Here the authors show, using a mouse model, that the degradation of perineuronal nets around fast spiking interneurons near the tumour contribute to seizures by increasing their membrane capacitance and firing.
Bhanu P. Tewari, Lata Chaunsali, Susan L. Campbell, Dipan C. Patel, Adam E. Goode, Harald Sontheimer   +5 more
doaj   +1 more source

Cross-species conservation in the regulation of parvalbumin by perineuronal nets

Frontiers in Neural Circuits, 2023
Parvalbumin (PV) neurons play an integral role in regulating neural dynamics and plasticity. Therefore, understanding the factors that regulate PV expression is important for revealing modulators of brain function. While the contribution of PV neurons to
Angela S. Wang, Xinghaoyun Wan, Xinghaoyun Wan, Daria-Salina Storch, Vivian Y. Li, Gilles Cornez, Jacques Balthazart, J. Miguel Cisneros-Franco, Etienne de Villers-Sidani, Etienne de Villers-Sidani, Jon T. Sakata, Jon T. Sakata, Jon T. Sakata   +12 more
doaj   +1 more source

Distribution of perineuronal nets in the adult rat neocortex. [PDF]

Somatosens Mot Res
Perineuronal nets (PNNs) are specialised extracellular matrix structures of the central nervous system that predominantly surround inhibitory interneurons. The development of PNNs is activity dependent and relies on sensory input to mature to an adult expression pattern, coinciding with the crysallization of synaptic circuitry following the closure of ...
Budhu K, Gomes H, Borukhov Y, Chu P, Brumberg JC.   +4 more
europepmc   +3 more sources

Loss of Perineuronal Net in ME7 Prion Disease [PDF]

Journal of Neuropathology & Experimental Neurology, 2008
Microglial activation and behavioral abnormalities occur before neuronal loss in experimental murine prion disease; the behavioral changes coincide with a reduction in synaptic plasticity. Because synaptic plasticity depends on an intact perineuronal net (PN), a specialized extracellular matrix that surrounds parvalbumin (PV)-positive GABAergic (gamma ...
Franklin, SL, Love, S, Greene, JRT, Betmouni, S   +3 more
openaire   +3 more sources

Perineuronal Nets: Subtle Structures with Large Implications

The Neuroscientist, 2022
Perineuronal nets (PNNs) are specialized structures of the extracellular matrix that surround the soma and proximal dendrites of certain neurons in the central nervous system, particularly parvalbumin-expressing interneurons. Their appearance overlaps the maturation of neuronal circuits and the closure of critical periods in different regions of the ...
Héctor Carceller, Yaiza Gramuntell, Patrycja Klimczak, Juan Nacher   +3 more
openaire   +5 more sources