Results 61 to 70 of about 134,149 (194)

Regulation of the E/I-balance by the neural matrisome

Frontiers in Molecular Neuroscience, 2023
In the mammalian cortex a proper excitatory/inhibitory (E/I) balance is fundamental for cognitive functions. Especially γ-aminobutyric acid (GABA)-releasing interneurons regulate the activity of excitatory projection neurons which form the second main ...
Cornelius Mueller-Buehl, David Wegrzyn, Juliane Bauch, Andreas Faissner   +3 more
doaj   +1 more source

Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity [PDF]

The Journal of Neuroscience, 2016
Perineuronal nets (PNNs) are unique extracellular matrix structures that wrap around certain neurons in the CNS during development and control plasticity in the adult CNS. They appear to contribute to a wide range of diseases/disorders of the brain, are involved in recovery from spinal cord injury, and are altered during aging, learning and memory, and
Sorg, Barbara A, Berretta, Sabina, Blacktop, Jordan M, Fawcett, James W, Kitagawa, Hiroshi, Kwok, Jessica CF, Miquel, Marta   +6 more
openaire   +6 more sources

Perineuronal nets affect memory and learning after synapse withdrawal

Translational Psychiatry, 2022
Perineuronal nets (PNNs) enwrap mature neurons, playing a role in the control of plasticity and synapse dynamics. PNNs have been shown to have effects on memory formation, retention and extinction in a variety of animal models.
Jiri Ruzicka, Marketa Dalecka, Kristyna Safrankova, Diego Peretti, Pavla Jendelova, Jessica C. F. Kwok, James W. Fawcett   +6 more
doaj   +1 more source

Cross-species conservation in the regulation of parvalbumin by perineuronal nets

Frontiers in Neural Circuits, 2023
Parvalbumin (PV) neurons play an integral role in regulating neural dynamics and plasticity. Therefore, understanding the factors that regulate PV expression is important for revealing modulators of brain function. While the contribution of PV neurons to
Angela S. Wang, Xinghaoyun Wan, Xinghaoyun Wan, Daria-Salina Storch, Vivian Y. Li, Gilles Cornez, Jacques Balthazart, J. Miguel Cisneros-Franco, Etienne de Villers-Sidani, Etienne de Villers-Sidani, Jon T. Sakata, Jon T. Sakata, Jon T. Sakata   +12 more
doaj   +1 more source

Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy

Nature Communications, 2018
Brain tumours are associated with epilepsy. Here the authors show, using a mouse model, that the degradation of perineuronal nets around fast spiking interneurons near the tumour contribute to seizures by increasing their membrane capacitance and firing.
Bhanu P. Tewari, Lata Chaunsali, Susan L. Campbell, Dipan C. Patel, Adam E. Goode, Harald Sontheimer   +5 more
doaj   +1 more source

Loss of Perineuronal Net in ME7 Prion Disease [PDF]

Journal of Neuropathology & Experimental Neurology, 2008
Microglial activation and behavioral abnormalities occur before neuronal loss in experimental murine prion disease; the behavioral changes coincide with a reduction in synaptic plasticity. Because synaptic plasticity depends on an intact perineuronal net (PN), a specialized extracellular matrix that surrounds parvalbumin (PV)-positive GABAergic (gamma ...
Franklin, SL, Love, S, Greene, JRT, Betmouni, S   +3 more
openaire   +3 more sources

Hyperacute Interleukin‐1β Production and Neutrophil Extracellular Trap Formation in the Cerebral Circulation of Stroke Patients with Large Vessel Occlusion

Annals of Neurology, EarlyView.
Acute ischemic stroke due to large vessel occlusion is associated with rapid intravascular immune activation. Analysis of arterial blood sampled distal to the thrombus during mechanical thrombectomy revealed increased extracellular adenosine triphosphate (ATP) and interleukin‐1β (IL‐1β) levels, evidence of inflammasome priming in monocytes, and ...
Justine Münsterberg, Caspar Brekenfeld, Hanna Englert, Marius Piepke, Regine J. Dress, Martin Oertel, Tina Fischer, Romy Hackbusch, Mingming Zha, Haodi Cai, Christian Casar, Ines S. Schädlich, Leo Winter, Alina Jander, Karoline Degenhardt, Maxim Bester, Fabian Flottmann, Uta Hanning, Brigitte Holst, Anna Worthman, Johanna Hiefner, Berenike Rutz, Eckhard Schlemm, Götz Thomalla, Bettina H. Clausen, Ann M. Stowe, Immo Prinz, Thiruma V. Arumugam, Markus Glatzel, Thomas Renné, Jens Fiehler, Eva Tolosa, Tim Magnus, Mathias Gelderblom   +33 more
wiley   +1 more source

WONOEP XVII appraisal: The role of the extracellular matrix in epilepsy

Epilepsia, EarlyView.
Abstract The extracellular matrix (ECM) is composed of proteoglycans and glycoproteins that regulate the external environment surrounding neurons, glia, and the vascular system. The ECM is vital for maintaining the structure and function of the brain and also acts as a reservoir for various signaling molecules and neurotransmitters, modulating synaptic
Eleonora Lugara, Erwin A. van Vliet, Alessia Romagnolo, Kevin Staley, Kyle P. Lillis, Chris Dulla, David C. Henshall, Katja Kobow   +7 more
wiley   +1 more source

WFA-labeled perineuronal nets in the macaque claustrum [PDF]

Claustrum, 2018
The claustrum (CLA) has been discussed as central to integrated conscious percepts, although recent evidence has emphasized a role in detecting sensory novelty or in amplifying correlated cortical inputs.We report that many neurons in the macaque CLA are ensheathed in perineuronal nets (PNNs), which contribute to synaptic stability and enhance neuronal
Mihovil Pletikos, Kathleen S. Rockland
openaire   +2 more sources

Heparan sulfate and glycomimetics: Advances in synthesis and biological applications for post‐stroke neurorepair

Neuroprotection, EarlyView.
ECM, extracellular matrix; BDNF, brain‐derived neuroptrophic factor; FGF, fibroblast growth factor; VEGF, vascular endothelial growth factor. Abstract Heparan sulfate, a structurally diverse glycosaminoglycan that is abundant in the central nervous system (CNS), orchestrates essential processes fundamental to neural plasticity, neurorepair, and ...
Mozammel H. Bhuiyan, Madeleine J. Smith, Simon F. R. Hinkley, Andrew N. Clarkson   +3 more
wiley   +1 more source