Results 61 to 70 of about 5,932 (219)

Molecular and cellular aspects of plasticity after neural injury [PDF]

, 2008
This review focuses on our effort to address plasticity of the nervous system after neural injury. We have used different animal models to examine cellular mechanisms of plasticity underlying the pathological and repair processes.
Chan, YS, Chen, LW, Shum, DKY, Yung, KKL
core   +1 more source

Sono‐Mechanogenetics: Linking Ultrasound Physics With Cellular Mechanobiology

Advanced Science, EarlyView.
Sono‐mechanogenetics links ultrasound physics with cellular mechanotransduction to enable noninvasive control of engineered biological systems. Acoustic forces generate distinct deformation modes that activate intracellular signaling pathways, which can be coupled to synthetic gene circuits to regulate diverse cellular functions, including gene ...
Yunjia Qu, Fan Wei, Chi Woo Yoon, Qifa Zhou, Yingxiao Wang   +4 more
wiley   +1 more source

Spatiotemporal dynamics of the postnatal developing primate brain transcriptome. [PDF]

, 2015
Developmental changes in the temporal and spatial regulation of gene expression drive the emergence of normal mature brain function, while disruptions in these processes underlie many neurodevelopmental abnormalities.
Amaral, David G, Bakken, Trygve E, Bennett, Jeffrey L, Bernard, Amy, Bertagnolli, Darren, Geschwind, Daniel H, Lee, Chang-Kyu, Lein, Ed S, Luo, Rui, Miller, Jeremy A, Parikshak, Neelroop N, Smith, Kimberly A, Sunkin, Susan M   +12 more
core   +1 more source

WONOEP XVII appraisal: The role of the extracellular matrix in epilepsy

Epilepsia, EarlyView.
Abstract The extracellular matrix (ECM) is composed of proteoglycans and glycoproteins that regulate the external environment surrounding neurons, glia, and the vascular system. The ECM is vital for maintaining the structure and function of the brain and also acts as a reservoir for various signaling molecules and neurotransmitters, modulating synaptic
Eleonora Lugara, Erwin A. van Vliet, Alessia Romagnolo, Kevin Staley, Kyle P. Lillis, Chris Dulla, David C. Henshall, Katja Kobow   +7 more
wiley   +1 more source

Influence of enriched environment on viral encephalitis outcomes: behavioral and neuropathological changes in albino Swiss mice. [PDF]

PLoS ONE, 2011
An enriched environment has previously been described as enhancing natural killer cell activity of recognizing and killing virally infected cells. However, the effects of environmental enrichment on behavioral changes in relation to virus clearance and ...
Aline Andrade de Sousa, Renata Reis, João Bento-Torres, Nonata Trévia, Nara Alves de Almeida Lins, Aline Passos, Zaire Santos, José Antonio Picanço Diniz, Pedro Fernando da Costa Vasconcelos, Colm Cunningham, Victor Hugh Perry, Cristovam Wanderley Picanço Diniz   +11 more
doaj   +1 more source

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

Brain Pathology, EarlyView.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga, Eva Fernández‐Muñoz, Jorge M. Charco, Enric Vidal, Diego Herrero‐Martínez, Josu Galarza‐Ahumada, Cristina Sampedro‐Torres‐Quevedo, Samanta Giler, Mariví Geijo, Gloria González‐Aseguinolaza, Hasier Eraña, Joaquín Castilla   +11 more
wiley   +1 more source

Perineuronal nets in brain physiology and disease

Seminars in Cell & Developmental Biology, 2019
Perineuronal nets (PNNs) in the brain are condensed glycosaminoglycan-rich extracellular matrix structures with heterogeneous composition yet specific organization. They typically assemble around a subset of fast-spiking interneurons that are implicated in learning and memory.
Damien Testa, Alain Prochiantz, Ariel A. Di Nardo   +2 more
openaire   +3 more sources

Dynamics of perineuronal nets over amphibian metamorphosis

Journal of Comparative Neurology, 2020
Abstract Extracellular matrix materials known as perineuronal nets (PNNs) have been shown to have remarkable consequences for the maturation of neural circuits and stabilization of behavior. It has been proposed that, due to the possibly long‐lived biochemical nature of their components, PNNs may be an important substrate by which ...
Jacob A. Edwards, Makayla Risch, Kim L. Hoke   +2 more
openaire   +3 more sources

Running-induced neurogenesis reduces CA1 perineuronal net density without substantial temporal delay

Molecular Brain
Aerobic exercise has many effects on brain function, particularly at the hippocampus. Exercise has been shown to increase the rate of adult neurogenesis within the dentate gyrus and decrease the density of perineuronal nets in area CA1.
Dylan J. Terstege, Duneesha Goonetilleke, Cindy K. Barha, Jonathan R. Epp   +3 more
doaj   +1 more source

Oxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia. [PDF]

, 2017
Parvalbumin inhibitory interneurons (PVIs) are crucial for maintaining proper excitatory/inhibitory balance and high-frequency neuronal synchronization.
A A Grace, A Gokhale, A Kulak, A Reif, A-S LaMantia, AJ Sharp, AR Santos, AW Johnson, B Rodriguez-Santiago, B Zikopoulos, C Bernard, C Kaur, C Le Magueresse, CA Cea-Del Rio, CL Beasley, CZ Wang, D Mehta, DA Lewis, DA Rossignol, DJ Lodge, DT Balu, DW Meechan, E Rees, EK Lucas, F Donato, F Filice, F Fonnum, F Longordo, G Cellot, G Modinos, GC Carlson, GE Hardingham, GS Tomassy, H Hu, H Lin, H Morishita, H Morishita, H Morishita, H Stefansson, HA Fachim, HC Brenhouse, HE Stevens, I Garate, J Coyle, J Egea, J Flatow, J Hirrlinger, J Rossier, J-H Cabungcal, JB Savitz, JC Kwok, JH Cabungcal, JH Cabungcal, JH Cabungcal, JH Cabungcal, JK Yao, JM Boyce-Rustay, JM Long, JM Yang, JM Yang, JP Debost, JW Young, K Fejgin, K Gill, K Munkholm, K Q Do, K Sakimura, KQ Do, KQ Do, L Lindemann, L Xin, LJ Kobrynski, LS Callahan, M Cuenod, M Didriksen, M Inan, M Inan, M Komitova, M Puhl, M Tosic, M Yanagi, MA Benneyworth, MJ Gandal, MM Behrens, MM Behrens, MW Pitts, N Brunetti-Pierri, N Gass, N Gogolla, NC Brown, O Akyol, O Kann, O Penagarikano, O Penagarikano, O Yizhar, P Fazzari, P Gravina, P O'Donnell, P O'Donnell, P Steullet, P Steullet, P Steullet, PB Walter, PJ Uhlhaas, R Gysin, S Ben-Shachar, S Giovanoli, S Giovanoli, S Schiavone, SA Mauney, SB Powell, Schizophrenia Working Group of the Psychiatric Genomics Consortium, SK Natarajan, SM Purcell, SY Kim, T Hikida, T K Hensch, T M Maynard, T Sakai, T Stojkovic, T Vaessen, The Dutch-Belgian Fragile X Consortium, TM Maynard, U Meyer, U Meyer, V Labrie, Y Goldshmit, Y Zhang, Z Jiang   +128 more
core   +2 more sources