Results 61 to 70 of about 3,965 (209)

Characterization of dermatan sulfate and chondroitin sulfate profiles during brain regeneration in Styela plicata

The FEBS Journal, EarlyView.
Adult ascidians are capable of regenerating their entire brains following injury, and glycosaminoglycans have been shown to either promote or inhibit neuritogenesis. In this study, dermatan 2,6‐disulfate (D2,6S) was identified as the predominant complex carbohydrate in the ascidian brain.
Taynan Motta Portal, Samara de Oliveira Pimentel, Bruno da Costa Rodrigues, Mauro Sérgio Gonçalves Pavão, Rodrigo Nunes da Fonseca, Cintia Monteiro de Barros   +5 more
wiley   +1 more source

Animals lacking link protein have attenuated perineuronal nets and persistent plasticity

, 2010
Chondroitin sulphate proteoglycans in the extracellular matrix restrict plasticity in the adult central nervous system and their digestion with chondroitinase reactivates plasticity.
Andrea Poli, T. T. Glant, M. R. Andrews, Kwok, Jessica C.F., J. W. Fawcett, Sathyaseelan S. Deepa, A. Poli, Fawcett, James W., Poli, Andrea, Forostyak, Serhiy, Carulli, Daniela, Melissa R. Andrews, James W. Fawcett, Daniela Carulli, Andrews, Melissa R., Tibor T. Glant, S. Forostyak, Andrews, Melissa Renee, Serhiy Forostyak, D. Carulli, Jessica C. F. Kwok, Elena Putignano, Glant, Tibor T., Kwok, Jessica C. F., J. C. Kwok, Tommaso Pizzorusso, E. Putignano, S. S. Deepa, Deepa, Sathyaseelan S., Putignano, Elena, Pizzorusso, Tommaso   +30 more
core   +1 more source

Dynamics of perineuronal nets over amphibian metamorphosis

Journal of Comparative Neurology, 2020
Abstract Extracellular matrix materials known as perineuronal nets (PNNs) have been shown to have remarkable consequences for the maturation of neural circuits and stabilization of behavior. It has been proposed that, due to the possibly long‐lived biochemical nature of their components, PNNs may be an important substrate by which ...
Jacob A. Edwards, Makayla Risch, Kim L. Hoke   +2 more
openaire   +3 more sources

Cerebellar plasticity and associative memories are controlled by perineuronal nets [PDF]

, 2020
Perineuronal nets (PNNs) are assemblies of extracellular matrix molecules, which surround the cell body and dendrites of many types of neuron and regulate neural plasticity. PNNs are prominently expressed around neurons of the deep cerebellar nuclei (DCN)
de Zeeuw, Chris I., Boele, H.J. (Henk-Jan), de Winter, Fred, de Waal, Matthijs, Winter, F, Canto, Cathrin B., Broersen, Robin, Verhaagen, J, Zeeuw, C.I. (Chris) de, Vries, S, de Vries, S. (Sharon), Verhaagen, J. (Joost), Carulli, D, Carulli, Daniela, Broersen, R. (Robin), Muir, E.M. (Elizabeth M.), Muir, Elizabeth M., Carulli, D. (Daniela), Verhaagen, Joost, Canto, Cathrin, de Zeeuw, Chris, de Winter, F. (Fred), de Waal, M, de Waal, M. (Matthijs), Meskovic, M, Boele, Henk Jan, Meškovic, M. (Maja), Meškovic, Maja, Muir, EM, Boele, Henk-jan, Canto, C.B. (Cathrin), de Vries, Sharon, Carulli, D., Broersen, Robin; id_orcid   +33 more
core   +1 more source

11-keto-β-boswellic acid and Z-guggulsterone suppress HMGB1/TLR4 pathway activity and modulate microglial polarization to remodel perineuronal nets after nerve injury

Journal of Advanced Research
Introduction: Remodeling of perineuronal nets is an emerging strategy for treating neuropathic pain (NP) and aligns with the traditional Chinese medicine concept of dispersing blood stasis dispersion and dredging collateral channels.
Yucheng Liao, Le Yang, Yi Ding, Chao Guo, Junping Hu, Xinliang Xu, Hui Zhu, Jianhua Yang, Minggao Zhao   +8 more
doaj   +1 more source

Perineuronal nets in HVC and plasticity in male canary song.

PLoS ONE, 2021
Songbirds learn their vocalizations during developmental sensitive periods of song memorization and sensorimotor learning. Some seasonal songbirds, called open-ended learners, recapitulate transitions from sensorimotor learning and song crystallization ...
Gilles Cornez, Shelley Valle, Ednei Barros Dos Santos, Ioana Chiver, Wendt Müller, Gregory F Ball, Charlotte A Cornil, Jacques Balthazart   +7 more
doaj   +1 more source

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

Brain Pathology, Volume 36, Issue 4, July 2026.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga, Eva Fernández‐Muñoz, Jorge M. Charco, Enric Vidal, Diego Herrero‐Martínez, Josu Galarza‐Ahumada, Cristina Sampedro‐Torres‐Quevedo, Samanta Giler, Mariví Geijo, Gloria González‐Aseguinolaza, Hasier Eraña, Joaquín Castilla   +11 more
wiley   +1 more source

Neuroanatomical Alterations in the CNTNAP2 Mouse Model of Autism Spectrum Disorder

Brain Sciences, 2023
Autism spectrum disorder (ASD) is associated with neurodevelopmental alterations, including atypical forebrain cellular organization. Mutations in several ASD-related genes often result in cerebral cortical anomalies, such as the abnormal developmental ...
Tanya Gandhi, Cade R. Canepa, Tolulope T. Adeyelu, Philip A. Adeniyi, Charles C. Lee   +4 more
doaj   +1 more source

From Lobectomy to Completion Thyroidectomy: A Cohort Study and Systematic Review

Clinical Endocrinology, Volume 105, Issue 1, Page 108-115, July 2026.
ABSTRACT Introduction The suggested management of thyroid cancer has been revised in the 2015 American Thyroid Association Management Guidelines, suggesting thyroid lobectomy alone for low‐risk thyroid cancer. However, precise patient selection is essential to identify who may need completion thyroidectomy (CT), avoiding the burden of a second surgery.
Idit Tessler, Tzahi Yamin, Liroy Caracucli, Josh Krasner, Shaked Shivatzki, Nir A. Gecel, Eran E. Alon, Galit Avior   +7 more
wiley   +1 more source

Early Destruction of the Extracellular Matrix around Parvalbumin-Immunoreactive Interneurons in Creutzfeldt-Jakob Disease

Neurobiology of Disease, 1999
GABA-interneurons immunoreactive (IR) for the calcium-binding protein parvalbumin are lost during the early stages of Creutzfeldt-Jakob disease (CJD) and diminution in their number may partially account for the neurological disturbances manifested in ...
Pavel V. Belichenko, Judith Miklossy, Brigitte Belser, Herbert Budka, Marco R. Celio   +4 more
doaj   +1 more source