Results 61 to 70 of about 124,158 (160)

Inhibitory circuit dysfunction as a potential contributor to cortical reorganization in Glioblastoma progression

Neurobiology of Disease
Glioblastoma (GBM) is a highly aggressive brain tumor that infiltrates surrounding brain tissue, profoundly affecting adjacent cortical areas. This study investigates how GBM reshapes the peritumoral cortex by examining plasticity changes in two GBM ...
Cristina Spalletti, Marta Scalera, Elisabetta Mori, Sabrin Haddad, Marco Mainardi, Daniele Cangi, Vinoshene Pillai, Elena Parmigiani, Silvia Landi, Matteo Caleo, Eleonora Vannini   +10 more
doaj   +1 more source

Toxoplasma gondii infection damages the perineuronal nets in a murine model [PDF]

Memorias do Instituto Oswaldo Cruz
BACKGROUND Behavioral and neurochemical alterations associated with toxoplasmosis may be influenced by the persistence of tissue cysts and activation of an immune response in the brain of Toxoplasma gondii-infected hosts.
Ywlliane da Silva Rodrigues Meurer, Ramayana Morais de Medeiros Brito, Valeria Palheta da Silva, Joelma Maria de Araujo Andade, Sarah Sophia Guedes Linhares, Antonio Pereira Junior, Valter Ferreira de Andrade-Neto, Andrea Lima de Sá, Claudio Bruno Silva de Oliveira   +8 more
doaj   +2 more sources

The Role of Anterior Insular Parvalbumin GABAergic Interneurons in Impulsivity‐Related and Alcohol‐Seeking Behaviors

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Adolescent impulsivity is linked to increased alcohol seeking and altered activation of anterior insular PV interneurons. Chemogenetic modulation of these neurons regulates inhibitory control and alcohol‐related behaviors, highlighting their role in vulnerability to alcohol use disorder.
F. Bezerra, G. J. D. Fernandes, A. Anjos‐Santos, C. A. Favoretto, B. T. Rodolpho, P. Palombo, V. Vialou, K. P. Abrahao, F. C. Cruz   +8 more
wiley   +1 more source

Early Destruction of the Extracellular Matrix around Parvalbumin-Immunoreactive Interneurons in Creutzfeldt-Jakob Disease

Neurobiology of Disease, 1999
GABA-interneurons immunoreactive (IR) for the calcium-binding protein parvalbumin are lost during the early stages of Creutzfeldt-Jakob disease (CJD) and diminution in their number may partially account for the neurological disturbances manifested in ...
Pavel V. Belichenko, Judith Miklossy, Brigitte Belser, Herbert Budka, Marco R. Celio   +4 more
doaj   +1 more source

The Astrocyte Clock Controls Circadian Perineuronal Net Remodeling, Synapse Strength and Learning Behavior

Glia, Volume 74, Issue 10, October 2026.
Bmal1 regulates astrocyte extracellular matrix (ECM) gene expression. Bmal1 deletion in astrocytes disrupts normal circadian rhythms in perineuronal nets (PNN) and reduces PNN content in the hippocampus. In parallel with loss of PNNs, deletion of the core circadian clock gene Bmal1 in astrocytes alters behavior and synaptic function in vivo.
Philip C. Smith, Elsa I. Quillin, Katheryn B. Lefton, Celia A. McKee, Brendan Dang, Thomas Papouin, Erik S. Musiek   +6 more
wiley   +1 more source

AMPA Receptor Antagonist NBQX Decreased Seizures by Normalization of Perineuronal Nets. [PDF]

PLoS ONE, 2016
Epilepsy is a serious brain disorder with diverse seizure types and epileptic syndromes. AMPA receptor antagonist 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzoquinoxaline-2,3-dione (NBQX) attenuates spontaneous recurrent seizures in rats.
Wen Chen, Yan-Shuang Li, Jing Gao, Xiao-Ying Lin, Xiao-Hong Li   +4 more
doaj   +1 more source

Frozen in Place: Proximity Labeling Maps Glial Interactomes Across Cell States

Glia, Volume 74, Issue 10, October 2026.
Proximity labeling enables cell‐type‐specific and spatially resolved mapping of glial protein networks. Proximity labeling approaches provide insights into glial function under physiological and pathological conditions. ABSTRACT Glial cells, including radial glia, oligodendrocyte precursor cells (OPCs), oligodendrocytes, astrocytes, and microglia, are ...
João Baltar, Rebecca Abati, Luísa Florido, Matthew G. Holt   +3 more
wiley   +1 more source

Harnessing Large‐Scale Multi‐Omics Data for Risk Prediction and Deep Phenotyping of Valvular Heart Diseases in the General Population

Advanced Science, Volume 13, Issue 53, 24 September 2026.
Large‐scale UK Biobank analyses identify clinical and proteomic signatures for early prediction of valvular heart disease and its subtypes. Proteins add predictive value for VHD, AVS, and MVR, with outcome‐specific compact panels showing translational potential. Multi‐layer evidence highlights matrix remodeling, protease regulation, immune inflammation,
Zhihao Jiang, Yang Liu, Mingyu Song, Ning Chen, Canqing Yu, Jun Lv, Eric Yuk Fai Wan, Lu Qi, Liming Li, Dianjianyi Sun, Bang Zheng   +10 more
wiley   +1 more source

Parvalbumin interneurons in Alzheimer's disease: Physiological insights and pathophysiological mechanisms

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Physiological and Pathological Alterations in PV+ Neurons: Under physiological conditions, PV+ interneurons exhibit fast‐spiking properties and generate gamma oscillations at the cost of high energy consumption. In AD, PV+ neurons display abnormalities in ion channels, dendrites, neurotransmission, energy metabolism, and neural oscillations, ultimately
Mengyan Wu, Xingdong Zeng, Yongle Cai, Haonan Chen, Qianying Li, Hao Yang   +5 more
wiley   +1 more source

Normal abducens nucleus perineuronal net immunostaining.

, 2015
Detection of perineuronal nets by aggrecan (ACAN) immunolabeling in the abducens nucleus (nVI) appeared similar in control subject and patient specimens.
Wolfgang Härtig (232795), Govind Nair (690278), Scott D. Z. Eggers (764607), Anja K. E. Horn (499553), Sigrun Roeber (46364), Daniel S. Reich (114120), R. John Leigh (283010)   +6 more
core   +1 more source