Results 81 to 90 of about 134,149 (194)

Perineuronal Nets in Neuropsychiatric Disorders

Brain Science Advances
Perineuronal nets (PNNs) are specialized extracellular matrix structures that enwrap select neuronal populations—particularly, parvalbumin-positive inhibitory interneurons.
Sonali Sikder, Ozlem Bozdagi Gunal
doaj   +1 more source

11-keto-β-boswellic acid and Z-guggulsterone suppress HMGB1/TLR4 pathway activity and modulate microglial polarization to remodel perineuronal nets after nerve injury

Journal of Advanced Research
Introduction: Remodeling of perineuronal nets is an emerging strategy for treating neuropathic pain (NP) and aligns with the traditional Chinese medicine concept of dispersing blood stasis dispersion and dredging collateral channels.
Yucheng Liao, Le Yang, Yi Ding, Chao Guo, Junping Hu, Xinliang Xu, Hui Zhu, Jianhua Yang, Minggao Zhao   +8 more
doaj   +1 more source

Perineuronal nets are phagocytosed by MMP‐9 expressing microglia and astrocytes in the SOD1G93A ALS mouse model

Neuropathology and Applied Neurobiology
Perineuronal nets (PNNs) are an extracellular matrix structure that encases excitable neurons. PNNs play a role in neuroprotection against oxidative stress.
Sang Won Cheung, Ekta Bhavnani, David G. Simmons, M. Bellingham, Peter G. Noakes   +4 more
semanticscholar   +1 more source

Characterization of dermatan sulfate and chondroitin sulfate profiles during brain regeneration in Styela plicata

The FEBS Journal, EarlyView.
Adult ascidians are capable of regenerating their entire brains following injury, and glycosaminoglycans have been shown to either promote or inhibit neuritogenesis. In this study, dermatan 2,6‐disulfate (D2,6S) was identified as the predominant complex carbohydrate in the ascidian brain.
Taynan Motta Portal, Samara de Oliveira Pimentel, Bruno da Costa Rodrigues, Mauro Sérgio Gonçalves Pavão, Rodrigo Nunes da Fonseca, Cintia Monteiro de Barros   +5 more
wiley   +1 more source

Toxoplasma gondii infection damages the perineuronal nets in a murine model [PDF]

Memorias do Instituto Oswaldo Cruz
BACKGROUND Behavioral and neurochemical alterations associated with toxoplasmosis may be influenced by the persistence of tissue cysts and activation of an immune response in the brain of Toxoplasma gondii-infected hosts.
Ywlliane da Silva Rodrigues Meurer, Ramayana Morais de Medeiros Brito, Valeria Palheta da Silva, Joelma Maria de Araujo Andade, Sarah Sophia Guedes Linhares, Antonio Pereira Junior, Valter Ferreira de Andrade-Neto, Andrea Lima de Sá, Claudio Bruno Silva de Oliveira   +8 more
doaj   +2 more sources

Early Destruction of the Extracellular Matrix around Parvalbumin-Immunoreactive Interneurons in Creutzfeldt-Jakob Disease

Neurobiology of Disease, 1999
GABA-interneurons immunoreactive (IR) for the calcium-binding protein parvalbumin are lost during the early stages of Creutzfeldt-Jakob disease (CJD) and diminution in their number may partially account for the neurological disturbances manifested in ...
Pavel V. Belichenko, Judith Miklossy, Brigitte Belser, Herbert Budka, Marco R. Celio   +4 more
doaj   +1 more source

Perineuronal nets in HVC and plasticity in male canary song.

PLoS ONE, 2021
Songbirds learn their vocalizations during developmental sensitive periods of song memorization and sensorimotor learning. Some seasonal songbirds, called open-ended learners, recapitulate transitions from sensorimotor learning and song crystallization ...
Gilles Cornez, Shelley Valle, Ednei Barros Dos Santos, Ioana Chiver, Wendt Müller, Gregory F Ball, Charlotte A Cornil, Jacques Balthazart   +7 more
doaj   +1 more source

The Astrocyte Clock Controls Circadian Perineuronal Net Remodeling, Synapse Strength and Learning Behavior

Glia, Volume 74, Issue 10, October 2026.
Bmal1 regulates astrocyte extracellular matrix (ECM) gene expression. Bmal1 deletion in astrocytes disrupts normal circadian rhythms in perineuronal nets (PNN) and reduces PNN content in the hippocampus. In parallel with loss of PNNs, deletion of the core circadian clock gene Bmal1 in astrocytes alters behavior and synaptic function in vivo.
Philip C. Smith, Elsa I. Quillin, Katheryn B. Lefton, Celia A. McKee, Brendan Dang, Thomas Papouin, Erik S. Musiek   +6 more
wiley   +1 more source

Inhibitory circuit dysfunction as a potential contributor to cortical reorganization in Glioblastoma progression

Neurobiology of Disease
Glioblastoma (GBM) is a highly aggressive brain tumor that infiltrates surrounding brain tissue, profoundly affecting adjacent cortical areas. This study investigates how GBM reshapes the peritumoral cortex by examining plasticity changes in two GBM ...
Cristina Spalletti, Marta Scalera, Elisabetta Mori, Sabrin Haddad, Marco Mainardi, Daniele Cangi, Vinoshene Pillai, Elena Parmigiani, Silvia Landi, Matteo Caleo, Eleonora Vannini   +10 more
doaj   +1 more source

Frozen in Place: Proximity Labeling Maps Glial Interactomes Across Cell States

Glia, Volume 74, Issue 10, October 2026.
Proximity labeling enables cell‐type‐specific and spatially resolved mapping of glial protein networks. Proximity labeling approaches provide insights into glial function under physiological and pathological conditions. ABSTRACT Glial cells, including radial glia, oligodendrocyte precursor cells (OPCs), oligodendrocytes, astrocytes, and microglia, are ...
João Baltar, Rebecca Abati, Luísa Florido, Matthew G. Holt   +3 more
wiley   +1 more source