Molecular Profiles of Pyramidal Neurons in the Superior Temporal Cortex in Schizophrenia [PDF]
, 2014 Disrupted synchronized oscillatory firing of pyramidal neuronal networks in the cerebral cortex in the gamma frequency band (i.e., 30–100 Hz) mediates many of the cognitive deficits and symptoms of schizophrenia.
Goldstein, Jill M. +11 more
core +2 more sources
Cilia in Nervous System Development, Function, and Disease
MedComm – Future Medicine, Volume 5, Issue 2, June 2026.Cilia are evolutionarily conserved organelles that function as essential sensory and motility platforms in the nervous system. This review outlines key cilia‐dependent signaling pathways and their roles in neural development and function. Furthermore, it highlights how ciliary dysfunction can lead to a variety of neurological disorders, known as ...
Qingchao Li, Anqi Zhang, Ting Song
wiley +1 more source
Toxoplasma gondii infection damages the perineuronal nets in a murine model [PDF]
Memorias do Instituto Oswaldo CruzBACKGROUND Behavioral and neurochemical alterations associated with toxoplasmosis may be influenced by the persistence of tissue cysts and activation of an immune response in the brain of Toxoplasma gondii-infected hosts.
Ywlliane da Silva Rodrigues Meurer +8 more
doaj +2 more sources
Protocol for assessing the role of hippocampal perineuronal nets in aversive memories
STAR Protocols, 2021 Summary: Perineuronal nets (PNNs) are emerging as critical regulators of memory-related neuronal processes. However, their exact contribution depends on type of memory, consolidation stage, or brain region, and remains to be fully investigated.
Vladimir Jovasevic +4 more
doaj +1 more source
Neuroinflammatory targets and treatments for epilepsy validated in experimental models [PDF]
, 2017 A large body of evidence that has accumulated over the past decade strongly supports the role of inflammation in the pathophysiology of human epilepsy.
Aronica, Eleonora +17 more
core +5 more sources
Brain and Behavior, Volume 16, Issue 5, May 2026.ABSTRACT Purpose This narrative review aims to explore how incorporating mechanical and thermal dimensions can complement and extend the classical Hodgkin‐Huxley (HH) model to enrich the understanding of headache and pain pathophysiology. Method This review examines the integration of three distinct concepts with the HH model.
Joan Crespi +5 more
wiley +1 more source
AMPA Receptor Antagonist NBQX Decreased Seizures by Normalization of Perineuronal Nets. [PDF]
PLoS ONE, 2016 Epilepsy is a serious brain disorder with diverse seizure types and epileptic syndromes. AMPA receptor antagonist 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzoquinoxaline-2,3-dione (NBQX) attenuates spontaneous recurrent seizures in rats.
Wen Chen +4 more
doaj +1 more source
Semaphorin3A, associated with perineuronal nets, regulates the development of the maturation of the central vestibular circuitry [PDF]
, 2014 Poster Presentation - Theme 5: NeuroscienceDuring the formative period of neural circuits, perineuronal nets (PN) are established to restrict plasticity of the circuit.
Chan, YS, Kwan, PY, Ma, CW, Shum, DKY
core
Blocking human fear memory with the matrix metalloproteinase inhibitor doxycycline [PDF]
, 2017 Learning to predict threat is a fundamental ability of many biological organisms, and a laboratory model for anxiety disorders. Interfering with such memories in humans would be of high clinical relevance.
BA Sorg +52 more
core +2 more sources
Axon Initial Segment: Structure, Biological Functions, Diseases, and Therapeutic Targets
MedComm, Volume 7, Issue 4, April 2026.The axon initial segment (AIS) is a specialized axonal domain critical for maintaining neuronal polarity, action potential initiation, and network stability. This review summarizes the necessary elements for maintaining AIS structure and plasticity, discussing crucial biological functions of AIS in neuronal signaling and the neural circuit homeostasis,
Dong‐Yan Song +4 more
wiley +1 more source