Results 81 to 90 of about 3,965 (209)

Removal of perineuronal nets leads to altered neuronal excitability and synaptic transmission in the visual cortex with distinct time courses

, 2022
Removal of perineuronal nets leads to altered neuronal excitability and synaptic transmission in the visual cortex with distinct time coursesRaw data of all figures.THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE.
LIU, L (via Mendeley Data)
core   +1 more source

Right medial temporal lobe mass in a 25‐year‐old male

Brain Pathology, EarlyView.
Jorge Samanamud, Cheyanne C. Slocum, Michael Christian Virata, Zied Abdullaev, Kenneth Aldape, Melissa Umphlett, Raymund L. Yong, Thomas P. Naidich, Nadejda M. Tsankova, Jamie M. Walker, Timothy E. Richardson   +10 more
wiley   +1 more source

Advanced 3D Platforms for Modeling CNS Neuroinflammation: Cell Integration, Techniques, and Challenges

Advanced Healthcare Materials, Volume 15, Issue 20, 27 May 2026.
This review summarizes the roles of key central nervous system cell types, the extracellular matrix, and the blood‐brain barrier in neuroinflammation, and their integration into diverse 3D culture systems. It examines major incorporation strategies, including direct co‐culture, hydrogel encapsulation, transwell migration assays, and bioprinting ...
Emmanuelle D. Aiyegbusi, Julia Di Stefano, Dearbhaile Dooley   +2 more
wiley   +1 more source

Code for "Responses in fast-spiking interneuron firing rates to parameter variations associated with degradation of perineuronal nets"

, 2023
Code used to generate data and plots in the paper “Responses in fast-spiking interneuron firing rates to parameter variations associated with degradation of perineuronal nets” submitted for publication in Journal of Computational Neuroscience.
Kine Ødegård Hanssen
core   +1 more source

Perineuronal nets in the rodent suprachiasmatic nucleus

Neuroscience
The circadian system maintains highly stable rhythms over the lifespan. The precision of the circadian clock emerges from the network organization of the master clock located in the suprachiasmatic nucleus (SCN). Perineuronal nets (PNNs), condensed extracellular matrix structures that are composed of chondroitin sulfate proteoglycans, help maintain ...
Patricia R. Blakely, Naila F. Jamani, Katelyn G. Horsley, Kiana Hampton, Michael C. Antle   +4 more
openaire   +2 more sources

Engineered Living Systems With Self‐Organizing Neural Networks: From Anatomy to Behavior and Gene Expression

Advanced Science, Volume 13, Issue 28, 18 May 2026.
Ectodermal tissue excised from Xenopus embryos self‐organizes into a three‐dimensional mucociliary organoid. Here, we generate a neural variant, termed neurobot, by implanting neural precursor cells. Neurobots develop mature neurons, adopt distinct morphologies, exhibit more complex motility, and respond differentially to neuroactive compounds. Imaging
Haleh Fotowat, Laurie O'Neill, Léo Pio‐Lopez, Megan M. Sperry, Patrick Erickson, Tiffany Lin, Michael Levin   +6 more
wiley   +1 more source

Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain

EBioMedicine, 2020
Background: Microglia, the brain's principal immune cell, are increasingly implicated in Alzheimer's disease (AD), but the molecular interfaces through which these cells contribute to amyloid beta (Aβ)-related neurodegeneration are unclear.
Joshua D. Crapser, Elizabeth E. Spangenberg, Rocio A. Barahona, Miguel A. Arreola, Lindsay A. Hohsfield, Kim N. Green   +5 more
doaj   +1 more source

Mechanotransduction in the Brain: Soliton Theory, Piezo Receptors and MR Elastography in Headache Pathophysiology

Brain and Behavior, Volume 16, Issue 5, May 2026.
ABSTRACT Purpose This narrative review aims to explore how incorporating mechanical and thermal dimensions can complement and extend the classical Hodgkin‐Huxley (HH) model to enrich the understanding of headache and pain pathophysiology. Method This review examines the integration of three distinct concepts with the HH model.
Joan Crespi, Axel Karl Gottfrid Nyman, Erling Tronvik, Lanfranco Pellesi, Igor Petrušić, Tobias Navarro Schröder   +5 more
wiley   +1 more source

Connexin Hemichannel Mimetic Peptide Attenuates Cortical Interneuron Loss and Perineuronal Net Disruption Following Cerebral Ischemia in Near-Term Fetal Sheep

, 2020
Perinatal hypoxia-ischemia is associated with disruption of cortical gamma-aminobutyric acid (GABA)ergic interneurons and their surrounding perineuronal nets, which may contribute to persisting neurological deficits.
Panzao Yang, Rashika N. Karunasinghe, Tania M. Fowke, Sumudu Ranasinghe, Colin R. Green, Justin M. Dean, Alistair J. Gunn, Guido Wassink, Laura Bennet, Joanne O. Davidson, Robert Galinsky, Jaya D. Prasad   +11 more
core   +1 more source

Axon Initial Segment: Structure, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 4, April 2026.
The axon initial segment (AIS) is a specialized axonal domain critical for maintaining neuronal polarity, action potential initiation, and network stability. This review summarizes the necessary elements for maintaining AIS structure and plasticity, discussing crucial biological functions of AIS in neuronal signaling and the neural circuit homeostasis,
Dong‐Yan Song, Lin Yuan, Weiguo Yang, Wen Li, Jia‐Yi Li   +4 more
wiley   +1 more source