Results 101 to 110 of about 134,149 (194)

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

Brain Pathology, Volume 36, Issue 4, July 2026.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga, Eva Fernández‐Muñoz, Jorge M. Charco, Enric Vidal, Diego Herrero‐Martínez, Josu Galarza‐Ahumada, Cristina Sampedro‐Torres‐Quevedo, Samanta Giler, Mariví Geijo, Gloria González‐Aseguinolaza, Hasier Eraña, Joaquín Castilla   +11 more
wiley   +1 more source

Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain

EBioMedicine, 2020
Background: Microglia, the brain's principal immune cell, are increasingly implicated in Alzheimer's disease (AD), but the molecular interfaces through which these cells contribute to amyloid beta (Aβ)-related neurodegeneration are unclear.
Joshua D. Crapser, Elizabeth E. Spangenberg, Rocio A. Barahona, Miguel A. Arreola, Lindsay A. Hohsfield, Kim N. Green   +5 more
doaj   +1 more source

From Lobectomy to Completion Thyroidectomy: A Cohort Study and Systematic Review

Clinical Endocrinology, Volume 105, Issue 1, Page 108-115, July 2026.
ABSTRACT Introduction The suggested management of thyroid cancer has been revised in the 2015 American Thyroid Association Management Guidelines, suggesting thyroid lobectomy alone for low‐risk thyroid cancer. However, precise patient selection is essential to identify who may need completion thyroidectomy (CT), avoiding the burden of a second surgery.
Idit Tessler, Tzahi Yamin, Liroy Caracucli, Josh Krasner, Shaked Shivatzki, Nir A. Gecel, Eran E. Alon, Galit Avior   +7 more
wiley   +1 more source

Interneuron Development Is Disrupted in Preterm Brains With Diffuse White Matter Injury: Observations in Mouse and Human

Frontiers in Physiology, 2019
Preterm brain injury, occurring in approximately 30% of infants born <32 weeks gestational age, is associated with an increased risk of neurodevelopmental disorders, such as autism spectrum disorder (ASD) and attention deficit hyperactivity disorder ...
Helen B. Stolp, Helen B. Stolp, Bobbi Fleiss, Bobbi Fleiss, Bobbi Fleiss, Yoko Arai, Veena Supramaniam, Regina Vontell, Regina Vontell, Sebastian Birtles, Abi G. Yates, Abi G. Yates, Ana A. Baburamani, Claire Thornton, Claire Thornton, Mary Rutherford, A. David Edwards, Pierre Gressens, Pierre Gressens   +18 more
doaj   +1 more source

Right medial temporal lobe mass in a 25‐year‐old male

Brain Pathology, Volume 36, Issue 5, September 2026.
Jorge Samanamud, Cheyanne C. Slocum, Michael Christian Virata, Zied Abdullaev, Kenneth Aldape, Melissa Umphlett, Raymund L. Yong, Thomas P. Naidich, Nadejda M. Tsankova, Jamie M. Walker, Timothy E. Richardson   +10 more
wiley   +1 more source

Postoperative Loss of Perineuronal Nets in the Hippocampal CA1 Region Results in Memory Consolidation Deficits.

Brain Research Bulletin
Postoperative cognitive dysfunction (POCD) is a common postoperative neurological complication, with memory consolidation deficits being one of its prominent features.
Zunsai Feng, Jiangnan Wu, Guicheng Wang, Ziqing Xu, Yanjing Guo, Shiyu Hao, Gong-ming Wang, Mengyuan Zhang   +7 more
semanticscholar   +1 more source

The role of brevican regulation in the antidepressant effects of electroacupuncture in a chronic stress rat model

Journal of Traditional Chinese Medical Sciences
Objective: To investigate the mechanism of electroacupuncture (EA) for treating depression and to explore the role of brevican in the medial prefrontal cortex (mPFC) in modulating stress susceptibility and the antidepressant effects of EA in rats ...
Cong Gai, Zhenyu Guo, Kai Guo, Shixin Yang, Yi Zhang, Huimin Zhu, Feifei Kan, Hongmei Sun, Die Hu   +8 more
doaj   +1 more source

Perineuronal Nets in the CNS: Architects of Memory and Potential Therapeutic Target in Neuropsychiatric Disorders

International Journal of Molecular Sciences
The extracellular matrix (ECM) within the brain possesses a distinctive composition and functionality, influencing a spectrum of physiological and pathological states.
Xue Li, Xian Wu, Tangsheng Lu, Chenyan Kuang, Yue Si, Wei Zheng, Zhonghao Li, Yanxue Xue   +7 more
semanticscholar   +1 more source

Ketamine preserves perineuronal nets in chronic stressed mice brain through the inhibition of microglia activation

IBRO Neuroscience Reports
Background: Deeper understanding of ketamine’s mechanism of action would contribute to the discovery of novel therapeutic targets with fast-onset actions. To gain insight on the mechanism underlying the antidepressant-like effects of ketamine, we focused
Jingwen Yang, Ting Huang, Meng Wang, Yingrui Xu, Xuan Li, Changqi Li, Wenyu Cao, Liyan He, Huamao Zhou   +8 more
doaj   +1 more source

Increased Excitability and Reduced Excitatory Synaptic Input Into Fast-Spiking CA2 Interneurons After Enzymatic Attenuation of Extracellular Matrix

Frontiers in Cellular Neuroscience, 2018
The neural extracellular matrix (ECM) is enriched with hyaluronic acid, chondroitin sulfate proteoglycans (CSPGs) and the glycoprotein tenascin-R, which play important roles in synaptic plasticity, as shown by studies of the CA1 region of the hippocampus.
Hussam Hayani, Inseon Song, Alexander Dityatev, Alexander Dityatev, Alexander Dityatev   +4 more
doaj   +1 more source