Results 101 to 110 of about 5,932 (219)

Chondroitin Sulfate Proteoglycans in CNS Development and Pathophysiology

Journal of Neuroscience Research, Volume 104, Issue 3, March 2026.
Chondroitin sulfate proteoglycans (CSPGs) are critical components of the extracellular matrix in the central nervous system (CNS). In the developing CNS, CSPGs regulate neural precursor cells, neuronal migration, axon guidance, synapse organization, and peri‐neuronal net assembly.
Seyed Mojtaba Hosseini, Soheila Karimi‐Abdolrezaee   +1 more
wiley   +1 more source

Modification of tenascin-R expression following unilateral labyrinthectomy in rats indicates its possible role in neural plasticity of the vestibular neural circuit

Neural Regeneration Research, 2015
We have previously found that unilateral labyrinthectomy is accompanied by modification of hyaluronan and chondroitin sulfate proteoglycan staining in the lateral vestibular nucleus of rats and the time course of subsequent reorganization of ...
Botond Gaal, Einar Örn Jóhannesson, Amit Dattani, Agnes Magyar, Ildikó Wéber, Clara Matesz   +5 more
doaj   +1 more source

A murine model for neuropsychiatric disorders associated with group A β-hemolytic streptococcal infection [PDF]

, 2004
A syndrome of motoric and neuropsychiatric symptoms comprising various elements, including chorea, hyperactivity, tics, emotional lability, and obsessive-compulsive symptoms, can occur in association with group A β-hemolytic streptococcal (GABHS ...
Hoffman, Kurt L., Hornig, Mady, Jabado, Omar J., Lipkin, W. Ian, Yaddanapudi, Kavitha   +4 more
core   +2 more sources

Prefrontal Cortex Dysfunction as a Precipitating Factor for Schizophrenia and Depression

Journal of Neurochemistry, Volume 170, Issue 3, March 2026.
Stress during adolescence or adulthood affects the ability of the prefrontal cortex (PFC) to adaptively regulate stress. Maladaptive adult stress leads to PFC hypofunction and a hypodopaminergic state in the medial, affect‐related ventral tegmental area (VTA), resulting in amotivation.
Daniela L. Uliana, Anthony A. Grace
wiley   +1 more source

Altered excitatory-inhibitory balance within somatosensory cortex is associated with enhanced plasticity and pain sensitivity in a mouse model of multiple sclerosis [PDF]

, 2016
S1 IHC in pre-symptomatic and clinical-onset EAE: PV+ cell counts, PNN counts, and Iba-1+ microglia counts. A) Representative fluorescence photomicrographs of PV+ staining (low-mag) in S1 from control (CFA) and EAE animals at the pre-symptomatic stage (7–
Bradley J. Kerr, Fred Colbourne, Glen Baker, Gustavo Tenorio, Ian Winship, Jayalakshmi Caliaperumal, Jee Su Suh, John W. Paylor, Liam E. Potter   +8 more
core   +4 more sources

Adrenarche as a regulator of sensitivity to early adversity

Journal of Neuroendocrinology, Volume 38, Issue 3, March 2026.
Abstract The human brain is highly sensitive to early adversity, which can have long‐term consequences for later mental health. It is also a time of rapid learning of social, motor and other skills, including language. It is proposed that pre‐adrenarche, the only epoch in human development in which cortisol is not accompanied by dehydroepiandrosterone (
J. Herbert
wiley   +1 more source

Interneuron Development Is Disrupted in Preterm Brains With Diffuse White Matter Injury: Observations in Mouse and Human

Frontiers in Physiology, 2019
Preterm brain injury, occurring in approximately 30% of infants born <32 weeks gestational age, is associated with an increased risk of neurodevelopmental disorders, such as autism spectrum disorder (ASD) and attention deficit hyperactivity disorder ...
Helen B. Stolp, Helen B. Stolp, Bobbi Fleiss, Bobbi Fleiss, Bobbi Fleiss, Yoko Arai, Veena Supramaniam, Regina Vontell, Regina Vontell, Sebastian Birtles, Abi G. Yates, Abi G. Yates, Ana A. Baburamani, Claire Thornton, Claire Thornton, Mary Rutherford, A. David Edwards, Pierre Gressens, Pierre Gressens   +18 more
doaj   +1 more source

Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression. [PDF]

, 2014
The role of remote astrocyte (AC) reaction to central or peripheral axonal insult is not clearly understood. Here we use a transgenic approach to compare the direct influence of normal with diminished AC reactivity on neuronal integrity and synapse ...
Adams-Carr, Kerala L, Barson, Daniel, Fawcett, James W, Franklin, Robin JM, Karadottir, Ragnhildur T, Kwok, Jessica C, Lakatos, András, Lau, Nike K, Sitnikov, Sergey, Tyzack, Giulia E, Zhao, Chao   +10 more
core   +4 more sources

Screening Biomarkers for Nerve Injury Using Weighted Gene Co‐Expression Network Analysis and Machine Learning

Brain and Behavior, Volume 16, Issue 2, February 2026.
This study identifies Atf3, Bin2, Fcgr2b, and Ucn as key diagnostic genes for nerve injury, linking them to neuroinflammation and immune cell dynamics. Fcgr2b was further shown to functionally promote neurite outgrowth. ABSTRACT Background Nerve injury triggers complex molecular responses involving immune activation and neuronal damage, yet the key ...
Shuming Cao, Chengyue Yu, Nana Wang, Jianhua Xu, Weiguo Xu   +4 more
wiley   +1 more source

Alpha-pinene and dizocilpine (MK-801) attenuate kindling development and astrocytosis in an experimental mouse model of epilepsy

IBRO Reports, 2020
Understanding the molecular and cellular mechanisms involved during the onset of epilepsy is crucial for elucidating the overall mechanism of epileptogenesis and therapeutic strategies.
Hiroshi Ueno, Atsumi Shimada, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yu Takahashi, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara   +9 more
doaj   +1 more source