Results 111 to 120 of about 134,149 (194)

Saccadic Palsy following Cardiac Surgery: Possible Role of Perineuronal Nets.

PLoS ONE, 2015
ObjectivePerineuronal nets (PN) form a specialized extracellular matrix around certain highly active neurons within the central nervous system and may help to stabilize synaptic contacts, promote local ion homeostasis, or play a protective role.
Scott D Z Eggers, Anja K E Horn, Sigrun Roeber, Wolfgang Härtig, Govind Nair, Daniel S Reich, R John Leigh   +6 more
doaj   +1 more source

Restoring vision in adult amblyopia by enhancing plasticity through deletion of the transcriptional repressor REST

iScience
Summary: Visual cortical plasticity is high during early life, but gradually decreases with development. This is due to the Otx2-driven maturation of intracortical inhibition that parallels the condensation of extracellular matrix components into ...
Dmytro Shmal, Giulia Mantero, Thomas Floss, Fabio Benfenati, José Fernando Maya-Vetencourt   +4 more
doaj   +1 more source

Swish!—All I Hear is Net—Perineuronal Net That is!

Epilepsy Currents
Contribution of Perineuronal Nets to Hyperexcitability in Pilocarpine-Induced Status Epilepticus Woo AM, Fleischel EJ, Patel DC, Sontheimer H.
openaire   +3 more sources

Adolescent intermittent ethanol exposure decreases perineuronal nets in the hippocampus in a sex dependent manner: Modulation through pharmacological inhibition of RPTPβ/ζ.

Neuropharmacology
Adolescence is a critical period for brain maturation in which this organ undergoes critical plasticity mechanisms that increase its vulnerability to the effects of alcohol.
Milagros Galán-Llario, Esther Gramage, A. Guerra, A. B. Torregrosa, A. Gasparyan, D. Navarro, F. Navarrete, M. García-Gutiérrez, J. Manzanares, G. Herradón   +9 more
semanticscholar   +1 more source

Phagocytosis of aggrecan-positive perineuronal nets surrounding motor neurons by reactive microglia expressing MMP-9 in TDP-43Q331K ALS model mice.

Neurobiology of Disease
Perineuronal nets (PNNs) are extracellular matrix structures that surround excitable neurons and their proximal dendrites. PNNs play an important role in neuroprotection against oxidative stress. Oxidative stress within motor neurons can act as a trigger
Sang Won Cheung, Emily F. Willis, David G. Simmons, M. Bellingham, Peter G. Noakes   +4 more
semanticscholar   +1 more source

Perineuronal nets in neurodegeneration

Oncotarget, 2016
Lemarchant, Sighild, Wojciechowski, Sara, Koistinaho, Jari   +2 more
openaire   +2 more sources

Perineuronal Nets in the Rat Medial Prefrontal Cortex Alter Hippocampal–Prefrontal Oscillations and Reshape Cocaine Self-Administration Memories

Journal of Neuroscience
The medial prefrontal cortex (mPFC) is a major contributor to relapse to cocaine in humans and to reinstatement in rodent models of cocaine use disorder.
Jereme C. Wingert, Jonathan D. Ramos, Sebastian X. Reynolds, Angela E. Gonzalez, R. M. Rose, D. Hegarty, Sue A. Aicher, Lydia G. Bailey, Travis E. Brown, Atheir I. Abbas, B. Sorg   +10 more
semanticscholar   +2 more sources

Choice impulsivity after repeated social stress is associated with increased perineuronal nets in the medial prefrontal cortex

Scientific Reports
Repeated stress can predispose to substance abuse. However, behavioral and neurobiological adaptations that link stress to substance abuse remain unclear.
Christopher A. Martinez, Harry Pantazopoulos, B. Gisabella, E. T. Stephens, Jacob Garteiser, Alberto Del Arco   +5 more
semanticscholar   +1 more source

Degradation of Perineuronal Nets in the Ventral Hippocampus of Adult Rats Recreates an Adolescent-Like Phenotype of Stress Susceptibility

Biological Psychiatry Global Open Science
Background Psychiatric disorders often emerge during late adolescence/early adulthood, a period with increased susceptibility to socioenvironmental factors that coincides with incomplete parvalbumin interneuron (PVI) development.
D. Colodete, Anthony A. Grace, F. Guimarães, Felipe V. Gomes   +3 more
semanticscholar   +1 more source

The omics techniques used in perineuronal nets research

Experimental Neurology
Neurodegenerative diseases (NDs) are progressive disorders characterized by neuronal degeneration in the central nervous system (CNS), ultimately leading to neurological dysfunction. Neurodegenerative progression is often associated with structural and functional alterations in perineuronal nets (PNNs).
Sihan, Huang, Jiao, Tang, Xiao, Wu, Huan, Xu, Sihui, Li, Hongying, Li, Siyu, Zhang, Guangxin, Xie, Tingyu, Wang, Xincheng, Pan, Ahmad, Fasih, Maochun, You, Zhanqiong, Zhong, Lushuang, Xie, Qiaofeng, Wu, Shuguang, Yu   +15 more
openaire   +2 more sources