Results 111 to 120 of about 5,932 (219)
Tackling obstacles for gene therapy targeting neurons: disrupting perineural nets with hyaluronidase improves transduction. [PDF]
, 2013 Gene therapy has been proposed for many diseases in the nervous system. In most cases for successful treatment, therapeutic vectors must be able to transduce mature neurons. However, both in vivo, and in vitro, where preliminary characterisation of viral
Kovac, S, Schorge, S, Wanisch, K
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Glucagon‐Like Peptide‐1 Targets in the Human Nodose Ganglion
Journal of Comparative Neurology, Volume 534, Issue 2, February 2026.Our findings demonstrate that the human nodose ganglion expresses Glp1r mRNA and reveal species similarities and differences in Glp1r expression between humans and mice. ABSTRACT Given the rapidly expanding clinical use of glucagon‐like peptide‐1 receptor (GLP1R) agonists—well‐known for their antidiabetic and antiobesity effects—it is increasingly ...
Warda Merchant +3 more
wiley +1 more source
The Mechanisms of Chondroitin Sulphate Lyases Treatment in Promotion of Axonal Growth [PDF]
, 2012 Poster PresentationIn Injured nerves, chondroitin sulphate (CS) is upregulated forming barriers with astrocytes/fibroblasts and other extracellular matrix molecules, and thereby hampering nerve regeneration.
Chan, YS, Shum, DKY, Tam, KW
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Journal of Traditional Chinese Medical SciencesObjective: To investigate the mechanism of electroacupuncture (EA) for treating depression and to explore the role of brevican in the medial prefrontal cortex (mPFC) in modulating stress susceptibility and the antidepressant effects of EA in rats ...
Cong Gai +8 more
doaj +1 more source
Enhancement of visual cortex plasticity by dark exposure [PDF]
, 2017 Dark rearing is known to delay the time course of the critical period for ocular dominance plasticity in the visual cortex. Recent evidence suggests that a period of dark exposure (DE) may enhance or reinstate plasticity even after closure of the ...
Erchova, Irina +3 more
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Postnatal lethality and chondrodysplasia in mice lacking both chondroitin sulfate N-acetylgalactosaminyltransferase-1 and -2 [PDF]
, 2017 Chondroitin sulfate (CS) is a sulfated glycosaminoglycan (GAG) chain. In cartilage, CS plays important roles as the main component of the extracellular matrix (ECM), existing as side chains of the major cartilage proteoglycan, aggrecan.
Fuseya Sayaka +16 more
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Chondroitinase ABC-I and -II linked chitosan microbeads increase neurtire length in CSPG-enriched astrocyte culture [PDF]
, 2014 Poster Presentation - Theme 5: NeuroscienceAfter spinal cord injury, axonal regrowth is often restricted due to upregulation of chondroitin sulfate proteoglycans (CSPGs) at the lesion site.
Kwok, LF, Shum, DKY
core
Saccadic Palsy following Cardiac Surgery: Possible Role of Perineuronal Nets.
PLoS ONE, 2015 ObjectivePerineuronal nets (PN) form a specialized extracellular matrix around certain highly active neurons within the central nervous system and may help to stabilize synaptic contacts, promote local ion homeostasis, or play a protective role.
Scott D Z Eggers +6 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2018 The neural extracellular matrix (ECM) is enriched with hyaluronic acid, chondroitin sulfate proteoglycans (CSPGs) and the glycoprotein tenascin-R, which play important roles in synaptic plasticity, as shown by studies of the CA1 region of the hippocampus.
Hussam Hayani +4 more
doaj +1 more source
Scaffolds for 3D in vitro culture of neural lineage cells. [PDF]
, 2017 Understanding how neurodegenerative disorders develop is not only a key challenge for researchers but also for the wider society, given the rapidly aging populations in developed countries.
Cameron, Neil R. +3 more
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