Results 121 to 130 of about 5,932 (219)

Restoring vision in adult amblyopia by enhancing plasticity through deletion of the transcriptional repressor REST

iScience
Summary: Visual cortical plasticity is high during early life, but gradually decreases with development. This is due to the Otx2-driven maturation of intracortical inhibition that parallels the condensation of extracellular matrix components into ...
Dmytro Shmal, Giulia Mantero, Thomas Floss, Fabio Benfenati, José Fernando Maya-Vetencourt   +4 more
doaj   +1 more source

Targeting Oxidative Stress and Aberrant Critical Period Plasticity in the Developmental Trajectory to Schizophrenia [PDF]

, 2017
Schizophrenia is a neurodevelopmental disorder reflecting a convergence of genetic risk and early life stress. The slow progression to first psychotic episode represents both a window of vulnerability as well as opportunity for therapeutic intervention ...
Cuenod, Michel, Do, Kim Q., Hensch, Takao K.   +2 more
core  

Perineuronal nets in neurodegeneration

Oncotarget, 2016
Lemarchant, Sighild, Wojciechowski, Sara, Koistinaho, Jari   +2 more
openaire   +2 more sources

Swish!—All I Hear is Net—Perineuronal Net That is!

Epilepsy Currents
Contribution of Perineuronal Nets to Hyperexcitability in Pilocarpine-Induced Status Epilepticus Woo AM, Fleischel EJ, Patel DC, Sontheimer H.
openaire   +3 more sources

The omics techniques used in perineuronal nets research

Experimental Neurology
Neurodegenerative diseases (NDs) are progressive disorders characterized by neuronal degeneration in the central nervous system (CNS), ultimately leading to neurological dysfunction. Neurodegenerative progression is often associated with structural and functional alterations in perineuronal nets (PNNs).
Sihan, Huang, Jiao, Tang, Xiao, Wu, Huan, Xu, Sihui, Li, Hongying, Li, Siyu, Zhang, Guangxin, Xie, Tingyu, Wang, Xincheng, Pan, Ahmad, Fasih, Maochun, You, Zhanqiong, Zhong, Lushuang, Xie, Qiaofeng, Wu, Shuguang, Yu   +15 more
openaire   +2 more sources

Structural and Functional Aberrations in the Cerebral Cortex of Tenascin-C Deficient Mice [PDF]

, 2017
The extracellular matrix glycoprotein tenascin-C (TNC) has been implicated in neural development and plasticity but many of its functions in vivo remain obscure. Here we addressed the question as to whether the constitutive absence of TNC in mice affects
Irintchev, Andrey, Kiss, Jozsef Z., Rollenhagen, Astrid, Schachner, Melitta, Troncoso, Edgardo   +4 more
core  

Neuroplasticity and amblyopia: vision at the balance point [PDF]

, 2017
Purpose of review: New insights into triggers and brakes of plasticity in the visual system are being translated into new treatment approaches which may improve outcomes not only in children, but also in adults.
Dahlmann-Noor, AH, Schwarzkopf, DS, Tailor, VK   +2 more
core  

Chondroitin sulfates act as extracellular gating modifiers on voltage-dependent ion channels. [PDF]

, 2008
Andrini, O, Clerici, M, Moriondo, Andrea, Negrini, Daniela, Passi, Alberto, Vigetti, Davide   +5 more
core   +1 more source

A type-5 metabotropic glutamate receptor-perineuronal net axis shapes the function of cortical GABAergic interneurons in chronic pain

Journal of Anesthesia, Analgesia and Critical Care
Parvalbumin-positive (PV+) interneurons (basket and chandelier cells) regulate the firing rate of pyramidal neurons in the cerebral cortex and play a key role in the generation of network oscillations in the cerebral cortex.
Giada Mascio, Ferdinando Nicoletti, Giuseppe Battaglia, Serena Notartomaso   +3 more
doaj   +1 more source

Adolescent cannabinoid exposure delays development of prefrontal cortex perineuronal nets and inhibitory interneurons. [PDF]

Neuroscience
Jacobs-Brichford E, Donka RM, Lasek AW, Hsu TM, Roitman JD.   +4 more
europepmc   +1 more source