Results 91 to 100 of about 134,149 (194)

Running to remember: The effects of exercise on perineuronal nets, microglia, and hippocampal angiogenesis in female and male mice

bioRxiv
Exercise is accepted as a positive health behaviour; however, the mechanisms of exercise on neuroprotection and cognitive health are not completely understood.
Madeleine G. Maheu, Noah James, Zach Clark, Alex J. Yang, Ridhi Patel, S. Beaudette, Rebecca E K MacPherson, Paula Duarte-Guterman   +7 more
semanticscholar   +1 more source

Parvalbumin interneurons in Alzheimer's disease: Physiological insights and pathophysiological mechanisms

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Physiological and Pathological Alterations in PV+ Neurons: Under physiological conditions, PV+ interneurons exhibit fast‐spiking properties and generate gamma oscillations at the cost of high energy consumption. In AD, PV+ neurons display abnormalities in ion channels, dendrites, neurotransmission, energy metabolism, and neural oscillations, ultimately
Mengyan Wu, Xingdong Zeng, Yongle Cai, Haonan Chen, Qianying Li, Hao Yang   +5 more
wiley   +1 more source

AMPA Receptor Antagonist NBQX Decreased Seizures by Normalization of Perineuronal Nets. [PDF]

PLoS ONE, 2016
Epilepsy is a serious brain disorder with diverse seizure types and epileptic syndromes. AMPA receptor antagonist 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzoquinoxaline-2,3-dione (NBQX) attenuates spontaneous recurrent seizures in rats.
Wen Chen, Yan-Shuang Li, Jing Gao, Xiao-Ying Lin, Xiao-Hong Li   +4 more
doaj   +1 more source

Alteration of perineuronal nets and parvalbumin interneurons in prefrontal cortex and hippocampus, and correlation with blood corticosterone in activity-based anorexia model mice.

Neurosciences research
Anorexia nervosa (AN) is an eating disorder characterized by restricted energy intake, severely underweight status, and frequent hyperactivity. Previous research has shown structural and functional alterations in the medial prefrontal cortex (mPFC) and ...
Hoang Duy Nguyen, Haruko Miyazaki, Hiroki Kawai, Ziyi Wang, S. Sakamoto, Manabu Takaki, T. Oohashi   +6 more
semanticscholar   +1 more source

Understanding neurodegeneration and regeneration in the CNS: New concepts, clinical investigations, and an unsung hero of neuroscience

Neuroprotection, EarlyView.
Piotr Walczak, Shen Li, Xunming Ji, Johannes Boltze   +3 more
wiley   +1 more source

Keratan Sulfate: An Electroconductive Glycosaminoglycan at the Interface of Sensory Perception and Neural Signaling

Journal of Neuroscience Research, Volume 104, Issue 8, August 2026.
Laboratory studies show KS has electroconductive properties with the ability to trap and transport protons in neurotransductive processes (Grotthuss proton shuttling). This maintains electrochemical gradients and fluxes at the neuronal cell surface in neural activation. Such processes are central to neuronal cell signaling and communication.
James Melrose
wiley   +1 more source

The Role of Meprins on the Brain Extracellular Matrix and Perineuronal Nets

The FASEB Journal, Volume 40, Issue 13, 15 July 2026.
Meprin β overexpression is implicated in Alzheimer's Disease. Recent studies identified brevican as a meprin β substrate, and this study demonstrates that meprin α co‐expression enhances meprin β‐mediated brevican cleavage. Further, neurocan and RPTPζ were identified as novel meprin β substrates in an N‐terminomics analysis of meprin β transgenic mice,
Simon Kreiselmaier, Maximilian Keller, Leonardo Nardi, Constantin Mueller, Nele von Wiegen, Kira Bickenbach, Lea Gröbner, Mohammad Abukhalaf, Andreas Tholey, Margareta M. Mueller, Hagen Körschgen, Michael J. Schmeisser, Christoph Becker‐Pauly, Claus U. Pietrzik   +13 more
wiley   +1 more source

Dexime: A Selectively Enzyme‐Degradable Hydrogel for Protein Therapeutic Release

Advanced Materials, Volume 38, Issue 38, 8 July 2026.
A dextrin‐oxime hydrogel (dexime) is produced using ketone or aldehyde modified dextrin and tetra‐oxyamine modified poly(ethylene glycol). The rheological and mechanical properties of dexime are tunable. Dexime is injectable, cytocompatible, hydrolytically stable, and selectively degradable by α‐amylase.
Quinton E. A. Sirianni, Nitzan Letko Khait, Adam Forman, Edward A. Armstrong, Karim Fouad, Molly S. Shoichet   +5 more
wiley   +1 more source

Hyaluronan (HA) Receptors: Discovery, Function & Pathology

Proteoglycan Research, Volume 4, Issue 3, July 2026.
ABSTRACT Hyaluronan (HA) is typically a long polymer of the repeating disaccharide, glucuronic acid‐β‐(1‐3)‐N‐acetylglucosamine polymerized by β(1‐4) bonds, with no obvious active site for biological activity. However, this dynamic polymer is vital for life in all metazoans and has a diverse array of functional characteristics due to the proteins that ...
Abby E. Bopp, Linda B. Pratt, Callan J. Schroder, Joseph D. Staab, Grant D. Hatcher, Joshua T. McWilliams, Michael C. Wilhelm, Ashley C. Texel, Edward N. Harris   +8 more
wiley   +1 more source

Modification of tenascin-R expression following unilateral labyrinthectomy in rats indicates its possible role in neural plasticity of the vestibular neural circuit

Neural Regeneration Research, 2015
We have previously found that unilateral labyrinthectomy is accompanied by modification of hyaluronan and chondroitin sulfate proteoglycan staining in the lateral vestibular nucleus of rats and the time course of subsequent reorganization of ...
Botond Gaal, Einar Örn Jóhannesson, Amit Dattani, Agnes Magyar, Ildikó Wéber, Clara Matesz   +5 more
doaj   +1 more source