Results 91 to 100 of about 3,965 (209)

Modification of tenascin-R expression following unilateral labyrinthectomy in rats indicates its possible role in neural plasticity of the vestibular neural circuit

Neural Regeneration Research, 2015
We have previously found that unilateral labyrinthectomy is accompanied by modification of hyaluronan and chondroitin sulfate proteoglycan staining in the lateral vestibular nucleus of rats and the time course of subsequent reorganization of ...
Botond Gaal, Einar Örn Jóhannesson, Amit Dattani, Agnes Magyar, Ildikó Wéber, Clara Matesz   +5 more
doaj   +1 more source

Age-dependent increase of perineuronal nets in the human hippocampus and precocious aging in epilepsy. [PDF]

Epilepsia Open
Lehner A, Hoffmann L, Rampp S, et al. Age-dependent increase of perineuronal nets in the human hippocampus and precocious aging in epilepsy. Epilepsia Open . 2024.OBJECTIVE: Perineuronal nets (PNN) are specialized extracellular matrix (ECM) components of
Lehner A, Hoffmann L, Rampp S, Coras R, Paulsen F, Frischknecht R, Hamer H, Walther K, Brandner S, Hofer W, Pieper T, Reisch LM, Bien CG, Blumcke I.   +13 more
europepmc   +2 more sources

An Extracellular Matrix Aging Clock Based on Circulating Matrisome Proteins Predicts Biological Aging and Disease

Aging Cell, Volume 25, Issue 4, April 2026.
A 14‐protein extracellular matrix aging clock derived from circulating matrisome proteins predicts chronological and biological age across cohorts and biofluids, distinguishes health from disease, and is modulated by rejuvenation interventions in mice, enabling the nomination of potential ECM targets for drug discovery to promote healthy aging ...
Loet Coenen, Adrian Molière, Benoit Lehallier, Jinte Middeldorp, Collin Y. Ewald   +4 more
wiley   +1 more source

The Role of Perineuronal Nets in Learning and Memory

, 2018
The balance between stability and plasticity in the brain determines our ability to learn. A key molecular regulator of this balance includes perineuronal nets.
Nath, Moushumi
core  

Lysophosphatidylcholine induced by fat transplantation regulates hyperalgesia by affecting the dysfunction of ACC perineuronal nets. [PDF]

iScience
The pathogenesis of hyperalgesia is complex and can lead to poor clinical treatment. Our study revealed that epididymal white adipose tissue (eWAT) from SNI mice is involved in the occurrence of hyperalgesia after adipose tissue transplantation.
Li J, Li Z, Liu Y, Li Y, Wu Y, Manyande A, Li Z, Xiang H.   +7 more
europepmc   +2 more sources

Reductionism in Engram Neuroscience

European Journal of Neuroscience, Volume 63, Issue 8, April 2026.
Reductionist methods inspire several seemingly incompatible explanations and ontologies. But such adversarial approaches can be fruitful for theorising in neuroscience. We argue that reductionist methods are at their most useful when coupled with integrative practices that include multiple heterarchical levels of organisation, various kinds of analysis,
Caitlin Mace, Fionn O'Sullivan, Scott R. Wilson   +2 more
wiley   +1 more source

Interneuron Development Is Disrupted in Preterm Brains With Diffuse White Matter Injury: Observations in Mouse and Human

Frontiers in Physiology, 2019
Preterm brain injury, occurring in approximately 30% of infants born <32 weeks gestational age, is associated with an increased risk of neurodevelopmental disorders, such as autism spectrum disorder (ASD) and attention deficit hyperactivity disorder ...
Helen B. Stolp, Helen B. Stolp, Bobbi Fleiss, Bobbi Fleiss, Bobbi Fleiss, Yoko Arai, Veena Supramaniam, Regina Vontell, Regina Vontell, Sebastian Birtles, Abi G. Yates, Abi G. Yates, Ana A. Baburamani, Claire Thornton, Claire Thornton, Mary Rutherford, A. David Edwards, Pierre Gressens, Pierre Gressens   +18 more
doaj   +1 more source

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, Volume 12, Issue 1, Page 65-85, Spring 2026.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

Role of perineuronal nets in the cerebellar nuclei: Insights from histology and behavior

, 2013
Thesis (Ph.D.)--University of Washington, 2013Perineuronal nets are structures in the extracellular matrix that previous work implicates in either inhibiting synaptic plasticity or protecting neurons from oxidative damage.
Mueller, Adrienne
core  

Alpha-pinene and dizocilpine (MK-801) attenuate kindling development and astrocytosis in an experimental mouse model of epilepsy

IBRO Reports, 2020
Understanding the molecular and cellular mechanisms involved during the onset of epilepsy is crucial for elucidating the overall mechanism of epileptogenesis and therapeutic strategies.
Hiroshi Ueno, Atsumi Shimada, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yu Takahashi, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara   +9 more
doaj   +1 more source