Results 91 to 100 of about 5,932 (219)

Therapeutic efficacy of microtube-embedded chondroitinase ABC in a canine clinical model of spinal cord injury [PDF]

, 2018
Many hundreds of thousands of people around the world are living with the long-term consequences of spinal cord injury and they need effective new therapies.
Albin, Barritt, Bartus, Biering-Sørensen, Bowes, Bradbury, Bradbury, Cafferty, Combrisson, Crespo, da Costa, Fawcett, Frank, Freedman, Gallucci, Garcia-Alias, Granger, Griffiths, Gutierrez-Quintana, Hamilton, Harris, Hilary Z Hu, Jefferson, Kwon, Kwon, Kwon, Lankhorst, Lee, Levine, Lin, Massey, Metz, Moore, Nashmi, Nick D Jeffery, Nicolas Granger, Nollet, Poncelet, Ravi V Bellamkonda, S Balakrishna Pai, Smith, Sylvestre, Tetzlaff, Toppercer, Watzlawick, Wicki, Yick   +46 more
core   +2 more sources

An Extracellular Matrix Aging Clock Based on Circulating Matrisome Proteins Predicts Biological Aging and Disease

Aging Cell, Volume 25, Issue 4, April 2026.
A 14‐protein extracellular matrix aging clock derived from circulating matrisome proteins predicts chronological and biological age across cohorts and biofluids, distinguishes health from disease, and is modulated by rejuvenation interventions in mice, enabling the nomination of potential ECM targets for drug discovery to promote healthy aging ...
Loet Coenen, Adrian Molière, Benoit Lehallier, Jinte Middeldorp, Collin Y. Ewald   +4 more
wiley   +1 more source

Combined Chondroitinase and KLF7 Expression Reduce Net Retraction of Sensory and CST Axons from Sites of Spinal Injury [PDF]

, 2017
Axon regeneration in the central nervous system is limited both by inhibitory extracellular cues and by an intrinsically low capacity for axon growth in some CNS populations.
Blackmore, Murray G., Hess, Evan, Nienhaus, Christopher, Wang, Zimei, Winsor, Kristen N.   +4 more
core   +1 more source

Reductionism in Engram Neuroscience

European Journal of Neuroscience, Volume 63, Issue 8, April 2026.
Reductionist methods inspire several seemingly incompatible explanations and ontologies. But such adversarial approaches can be fruitful for theorising in neuroscience. We argue that reductionist methods are at their most useful when coupled with integrative practices that include multiple heterarchical levels of organisation, various kinds of analysis,
Caitlin Mace, Fionn O'Sullivan, Scott R. Wilson   +2 more
wiley   +1 more source

Perineuronal nets in the rodent suprachiasmatic nucleus

Neuroscience
The circadian system maintains highly stable rhythms over the lifespan. The precision of the circadian clock emerges from the network organization of the master clock located in the suprachiasmatic nucleus (SCN). Perineuronal nets (PNNs), condensed extracellular matrix structures that are composed of chondroitin sulfate proteoglycans, help maintain ...
Patricia R. Blakely, Naila F. Jamani, Katelyn G. Horsley, Kiana Hampton, Michael C. Antle   +4 more
openaire   +2 more sources

Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain

EBioMedicine, 2020
Background: Microglia, the brain's principal immune cell, are increasingly implicated in Alzheimer's disease (AD), but the molecular interfaces through which these cells contribute to amyloid beta (Aβ)-related neurodegeneration are unclear.
Joshua D. Crapser, Elizabeth E. Spangenberg, Rocio A. Barahona, Miguel A. Arreola, Lindsay A. Hohsfield, Kim N. Green   +5 more
doaj   +1 more source

Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: A "central hub" in schizophrenia pathophysiology? [PDF]

, 2016
Accumulating evidence points to altered GABAergic parvalbumin-expressing interneurons and impaired myelin/axonal integrity in schizophrenia. Both findings could be due to abnormal neurodevelopmental trajectories, affecting local neuronal networks and ...
A. Monin, Abekawa, Atallah, Atkuri, Avshalumov, Back, Baker, Ballesteros, Bartos, Baud, Behrens, Behrens, Belforte, Bentsen, Berk, Berk, Beurdeley, Bilbo, Bodhinathan, Brenhouse, Bridges, Brown, Buckholtz, Buelna-Chontal, Bulut, Byne, Cabungcal, Cabungcal, Cabungcal, Cadet, Cai, Callahan, Cao, Cardin, Carlen, Carlson, Carmeli, Cavaliere, Chattopadhyaya, Chew, Choi, Clay, Cleland, Corcoba, Coyle, Cyr, D. Dwir, Dalmau, das Neves Duarte, Davis, Dell'Anna, Dickerson, Dityatev, Do, Do, Do, Do, Donato, Eluvathingal, Fan, Fan, Fan, Farokhnia, Farr, Fazzari, Fitzsimmons, Fournier, Fragoso, French, Fries, Fromer, Fuchs, Fukuda, Gandal, Garate, Gawryluk, Gokhale, Goldshmit, Gravina, Gulyas, Gysin, Gysin, Hakak, Hardingham, Harris, Harris, Harte, Hikida, Hof, Hoftman, Homayoun, Huang, Hwang, Ibi, Insel, J.H. Cabungcal, Jana, Javitt, Jenkins, Jiang, Jiang, Johnson, Jones, K.Q. Do, Kann, Kantrowitz, Katsel, Kaur, Kerns, Kettenmann, Kinney, Kirov, Kocsis, Koga, Kohr, Komitova, Korotkova, Krishnan, Krystal, Kulak, Kulak, Kyriakopoulos, Lante, Lataster, Lataster, Lavoie, Lavoie, Lazarewicz, Lewis, Leza, Li, Li, Lisman, Liu, Lodge, Lodge, Lucas, Lutgen, M. Cuenod, Makinodan, Makinodan, Mandal, Martins-de-Souza, Massi, Mauney, McGee, McNally, Mehta, Meiser, Meyer, Meyer, Meyer, Miyata, Mizrahi, Moller, Monin, Morishita, Morishita, Muller, Muller, Mustafa, Myin-Germeys, Myin-Germeys, O'Donnell, O'Donnell, Oorschot, Otte, P. O'Donnell, P. Steullet, Paintlia, Pantazopoulos, Papadia, Park, Patz, Penschuck, Pinteaux, Pitts, Poels, Potvin, Powell, Purcell, Rabinovic, Ray, Reddy, Robinson, Rodriguez-Santiago, Rotaru, Rouhinen, Roux, Saetre, Schiavone, Shirai, Sinn, Smith, Smyth, Sohal, Song, Stefansson, Steiner, Steullet, Steullet, Steullet, Steullet, Stevens, Stojkovic, Sullivan, Takahashi, Takao, Timms, Tkachev, Tosic, Tseng, Tseng, Uhlhaas, Uhlhaas, Umbricht, Uranova, Uranova, Uranova, Valko, van Berckel, Vinson, Walter, Wang, Wang, Wang, Wang, Wang, Wen, Whitford, Wulff, Yanagi, Yao, Yao, Zafarullah, Zhang, Zhang, Zhang   +237 more
core   +1 more source

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, Volume 12, Issue 1, Page 65-85, Spring 2026.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

A neural extracellular matrix-based method for in vitro hippocampal neuron culture and dopaminergic differentiation of neural stem cells [PDF]

, 2013
BACKGROUND: The ability to recreate an optimal cellular microenvironment is critical to understand neuronal behavior and functionality in vitro.
Adolfo López de Munain, Ander Izeta, Antonio G García, Fabio Cavaliere, José Álava, Marcos Maroto, Neia Naldaiz-Gastesi, Patricia García-Parra   +7 more
core   +3 more sources

Right medial temporal lobe mass in a 25‐year‐old male

Brain Pathology, EarlyView.
Jorge Samanamud, Cheyanne C. Slocum, Michael Christian Virata, Zied Abdullaev, Kenneth Aldape, Melissa Umphlett, Raymund L. Yong, Thomas P. Naidich, Nadejda M. Tsankova, Jamie M. Walker, Timothy E. Richardson   +10 more
wiley   +1 more source