Results 31 to 40 of about 5,932 (219)

Synaptic Hyaluronan Synthesis and CD44-Mediated Signaling Coordinate Neural Circuit Development

Cells, 2021
The hyaluronan-based extracellular matrix is expressed throughout nervous system development and is well-known for the formation of perineuronal nets around inhibitory interneurons.
Emily S. Wilson, Karen Litwa
doaj   +1 more source

TGFβ signaling is associated with changes in inflammatory gene expression and perineuronal net degradation around inhibitory neurons following various neurological insults. [PDF]

, 2017
Brain damage due to stroke or traumatic brain injury (TBI), both leading causes of serious long-term disability, often leads to the development of epilepsy. Patients who develop post-injury epilepsy tend to have poor functional outcomes.
Becker, Albert, Friedman, Alon, Gu, Feng, Heinemann, Uwe, KAUFER, daniela, Kim, Soo, Lippmann, Kristina, Milikovsky, Dan, Morrissey, Christapher, Parada, Isabel, Prince, David, Senatorov, Vladimir, Vazquez, Oscar   +12 more
core   +5 more sources

Perineuronal Nets and Metal Cation Concentrations in the Microenvironments of Fast-Spiking, Parvalbumin-Expressing GABAergic Interneurons: Relevance to Neurodevelopment and Neurodevelopmental Disorders

Biomolecules, 2021
Because of their abilities to catalyze generation of toxic free radical species, free concentrations of the redox reactive metals iron and copper are highly regulated.
Jessica A. Burket, Jason D. Webb, Stephen I. Deutsch   +2 more
doaj   +1 more source

Perineuronal Nets and Their Role in Synaptic Homeostasis [PDF]

International Journal of Molecular Sciences, 2019
Extracellular matrix (ECM) molecules that are released by neurons and glial cells form perineuronal nets (PNNs) and modulate many neuronal and glial functions. PNNs, whose structure is still not known in detail, surround cell bodies and dendrites, which leaves free space for synapses to come into contact.
Mateusz Bosiacki, Magdalena Gąssowska-Dobrowolska, Klaudyna Kojder, Marta Fabiańska, Dariusz Jeżewski, Izabela Gutowska, Anna Lubkowska   +6 more
openaire   +2 more sources

Beta3Gn-T7 Is a Keratan Sulfate β1,3 N-Acetylglucosaminyltransferase in the Adult Brain

Frontiers in Neuroanatomy, 2022
Keratan sulfate (KS) glycan is covalently attached to a core protein of proteoglycans. KS is abundant in neuropils and presents densely in close proximity to the perineuronal region of the perineuronal net-positive neurons in the adult brain under ...
Yoshiko Takeda-Uchimura, Kazuchika Nishitsuji, Midori Ikezaki, Tomoya O. Akama, Yoshito Ihara, Fabrice Allain, Kenji Uchimura   +6 more
doaj   +1 more source

A Sweet Talk: The Molecular Systems of Perineuronal Nets in Controlling Neuronal Communication [PDF]

, 2017
Perineuronal nets (PNNs) are mesh-like structures, composed of a hierarchical assembly of extracellular matrix molecules in the central nervous system (CNS), ensheathing neurons and regulating plasticity.
Arranz, Baig, Banerjee, Baranova, Barritt, Beebe, Beurdeley, Blosa, Bradbury, Brakebusch, Brückner, Brückner, Bukalo, Bukalo, Cabungcal, Caillard, Carstens, Carulli, Carulli, Carulli, Chang, Cheah, Corvetti, Coulson-Thomas, Dauth, Day, de Winter, Deepa, Deepa, Dick, Dityatev, Donato, Favuzzi, Foscarin, Frischknecht, Galtrey, Galtrey, Geissler, Giamanco, Gogolla, Grøndahl, Gu, Gurevicius, Happel, Heleen M. van 't Spijker, Hensch, Hisaoka, Hylin, Härtig, Härtig, Jansen, Jessica C. F. Kwok, Kochlamazashvili, Kwok, Kwok, Lafarga, Lander, Lee, Lensjø, Lensjø, Mabuchi, Matthews, McRae, Miyata, Miyata, Miyata, Morawski, Morawski, Morawski, Morikawa, Orlando, Pantazopoulos, Pelkey, Pizzorusso, Pizzorusso, Romberg, Rossier, Shinozaki, Smith, Spatazza, Spreafico, Steullet, Sugiyama, Suttkus, Suzuki, Vo, Wang, Yamada, Ye   +88 more
core   +2 more sources

N-acetylgalactosamine positive perineuronal nets in the saccade-related-part of the cerebellar fastigial nucleus do not maintain saccade gain. [PDF]

PLoS ONE, 2014
Perineuronal nets (PNNs) accumulate around neurons near the end of developmental critical periods. PNNs are structures of the extracellular matrix which surround synaptic contacts and contain chondroitin sulfate proteoglycans.
Adrienne Mueller, Adam Davis, Steven S Carlson, Farrel R Robinson   +3 more
doaj   +1 more source

A „ruha” teszi a neuront – az extracelluláris mátrix különböző megjelenési formái gerincesek központi idegrendszerében [PDF]

, 2013
Introduction: Extracellular matrix is a key component of most connective tissues. For decades, the presence of this chemically heterogeneous interface has been largely unaddressed or even denied in the central nervous system.
Gáti, Georgina, Lendvai, Dávid
core   +1 more source

Chronic silencing of subsets of cortical layer 5 pyramidal neurons has a long-term influence on the laminar distribution of parvalbumin interneurons and the perineuronal nets. [PDF]

J Anat
Chronic silencing of subsets of layer 5 projection neurons has distinct effects on the laminar distribution of PV interneurons and the perineuronal nets in the adult primary motor and somatosensory cortex. Abstract Neural networks are established throughout cortical development, which require the right ratios of glutamatergic and GABAergic neurons ...
Szabó FP, Sigutova V, Schneider AM, Hoerder-Suabedissen A, Molnár Z.   +4 more
europepmc   +2 more sources

Perineuronal nets: Cruise from a honeycomb to the safety nets

Brain Research Bulletin, 2022
The extracellular matrix (ECM) is a significant component of the brain, constituting up to 20 % of the brain volume and perform multifarious functions during development, maturation and regeneration of the central nervous system (CNS). ECM molecules assemble systematically to form a relatively rigid and unique lattice-like structure, known as ...
Urmilla John, Nisha Patro, Ishan Patro
openaire   +2 more sources