Results 31 to 40 of about 134,149 (194)

Perineuronal Nets on CA2 Pyramidal Cells and Parvalbumin-Expressing Cells Differentially Regulate Hippocampal-Dependent Memory [PDF]

J Neurosci
Perineuronal nets (PNNs) are a specialized extracellular matrix that surrounds certain populations of neurons, including (inhibitory) parvalbumin (PV)-expressing interneurons throughout the brain and (excitatory) CA2 pyramidal neurons in hippocampus ...
Georgia M. Alexander, Viktoriya D. Nikolova, Tristan M. Stöber, Artiom Gruzdev, S. Moy, S. Dudek   +5 more
semanticscholar   +2 more sources

Differential Impact of Adolescent or Adult Stress on Behavior and Cortical Parvalbumin Interneurons and Perineuronal Nets in Male and Female Mice [PDF]

Int J Neuropsychopharmacol
Background Stress has become a common public health concern, contributing to the rising prevalence of psychiatric disorders. Understanding the impact of stress considering critical variables, such as age, sex, and individual differences, is of the utmost
Thamyris Santos-Silva, Beatriz Kinchin de Souza, D. Colodete, L. Campos, Thaís Santos Almeida Lima Francisco S Guimarães, Felipe V. Gomes   +5 more
semanticscholar   +2 more sources

Perineuronal Nets and CNS Plasticity and Repair [PDF]

Neural Plasticity, 2016
The extracellular matrix (ECM) of the nervous system regulates numerous events during development, from neurogenesis and gliogenesis to circuitry formation, as well as in adulthood, affecting damage responses, plasticity, and regeneration. Substantial changes in the quantity and the composition of ECM occur during development.
Daniela Carulli, Jessica C. F. Kwok, Tommaso Pizzorusso   +2 more
doaj   +6 more sources

Circadian Rhythms of Perineuronal Net Composition [PDF]

eneuro, 2020
Abstract Perineuronal nets (PNNs) are extracellular matrix (ECM) structures that envelop neurons and regulate synaptic functions. Long thought to be stable structures, PNNs have been recently shown to respond dynamically during learning, potentially regulating the formation of new synapses. We postulated that PNNs
Harry Pantazopoulos, Barbara Gisabella, Lindsay Rexrode, David Benefield, Emrah Yildiz, Phoebe Seltzer, Jake Valeri, Gabriele Chelini, Anna Reich, Magdalena Ardelt, Sabina Berretta   +10 more
openaire   +3 more sources

Lesion-induced changes of brevican expression in the perineuronal net of the superior vestibular nucleus

Neural Regeneration Research, 2022
Damage to the vestibular sense organs evokes static and dynamic deficits in the eye movements, posture and vegetative functions. After a shorter or longer period of time, the vestibular function is partially or completely restored via a series of ...
Agnes Magyar, Eva Racz, Clara Matesz, Ervin Wolf, Peter Kiss, Botond Gaal   +5 more
doaj   +1 more source

Perineuronal Net Dynamics in the Pathophysiology of Epilepsy [PDF]

Epilepsy Currents, 2021
Perineuronal nets (PNNs) are condensed extracellular matrix (ECM) assemblies of polyanionic chondroitin sulfate proteoglycans, hyaluronan, and tenascins that primarily wrap around GABAergic parvalbumin (PV) interneurons. During development, PNN formation terminates the critical period of neuroplasticity, a process that can be reversed by experimental ...
Lata Chaunsali, Bhanu P. Tewari, Harald Sontheimer   +2 more
openaire   +3 more sources

The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders [PDF]

Frontiers in Molecular Neuroscience, 2018
Perineuronal nets (PNN) are extracellular matrix (ECM) assemblies that preferentially ensheath parvalbumin (PV) expressing interneurons. Converging evidence indicates that PV cells and PNN are impaired in a variety of neurological disorders. PNN development and maintenance is necessary for a number of processes within the CNS, including regulation of ...
Teresa H. Wen, Devin K. Binder, Devin K. Binder, Iryna M. Ethell, Iryna M. Ethell, Khaleel A. Razak, Khaleel A. Razak   +6 more
openaire   +5 more sources

Experience-dependent plasticity and modulation of growth regulatory molecules at central synapses. [PDF]

PLoS ONE, 2011
Structural remodeling or repair of neural circuits depends on the balance between intrinsic neuronal properties and regulatory cues present in the surrounding microenvironment.
Simona Foscarin, Danilo Ponchione, Ermira Pajaj, Ketty Leto, Maciej Gawlak, Grzegorz M Wilczynski, Ferdinando Rossi, Daniela Carulli   +7 more
doaj   +1 more source

Perineuronal net degradation in epilepsy [PDF]

Epilepsia, 2015
SummaryObjectiveWe previously reported loss of perineuronal net (PN) immunohistochemical staining around parvalbumin‐positive interneurons in the hippocampus of rats after an episode of status epilepticus (SE). We hypothesized that the loss of thePNcould alter seizure susceptibility and that matrix metalloproteinases (MMPs) were candidates for ...
Elyse K. Rankin‐Gee, Paulette A. McRae, Esther Baranov, Stephanie Rogers, Luke Wandrey, Brenda E. Porter   +5 more
openaire   +2 more sources

Primary cilia are required for the persistence of memory and stabilization of perineuronal nets

iScience, 2021
Summary: It is well established that the formation of episodic memories requires multiple hippocampal mechanisms operating on different time scales.
Vladimir Jovasevic, Hui Zhang, Farahnaz Sananbenesi, Anita L. Guedea, Kizhake V. Soman, John E. Wiktorowicz, Andre Fischer, Jelena Radulovic   +7 more
doaj   +1 more source