Results 31 to 40 of about 124,158 (160)
Hypothalamic Perineuronal Nets Are Regulated by Sex and Dietary Interventions
Frontiers in Physiology, 2021 Perineuronal nets (PNNs) are widely present in the hypothalamus, and are thought to provide physical protection and ion buffering for neurons and regulate their synaptic plasticity and intracellular signaling.
Nan Zhang +21 more
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Perineuronal nets in memory processing and behavior
, 2020 This doctoral thesis entails work on learning and memory with the goal of understanding mechanisms that regulate plasticity and affect memory processing.
Thompson, Elise Holter
core +1 more source
Component-specific reduction in perineuronal nets in senescence-accelerated mouse strains
IBRO Neuroscience Reports, 2023 With increased life expectancy, age-related diseases are a significant health concern in Western societies. Animal models (e.g., rodents) have been used to understand age-related changes in brain function—particularly through the senescence-accelerated ...
Hiroshi Ueno +7 more
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Expression of aggrecan components in perineuronal nets in the mouse cerebral cortex
IBRO Reports, 2018 Specific regions of the cerebral cortex are highly plastic in an organism’s lifetime. It is thought that perineuronal nets (PNNs) regulate plasticity, but labeling for Wisteria floribunda agglutinin (WFA), which is widely used to detect PNNs, is observed
Hiroshi Ueno +9 more
doaj +1 more source
Perineuronal nets affect memory and learning after synapse withdrawal
Translational Psychiatry, 2022 Perineuronal nets (PNNs) enwrap mature neurons, playing a role in the control of plasticity and synapse dynamics. PNNs have been shown to have effects on memory formation, retention and extinction in a variety of animal models.
Jiri Ruzicka +6 more
doaj +1 more source
Regulation of the E/I-balance by the neural matrisome
Frontiers in Molecular Neuroscience, 2023 In the mammalian cortex a proper excitatory/inhibitory (E/I) balance is fundamental for cognitive functions. Especially γ-aminobutyric acid (GABA)-releasing interneurons regulate the activity of excitatory projection neurons which form the second main ...
Cornelius Mueller-Buehl +3 more
doaj +1 more source
Two Algebraic Process Semantics for Contextual Nets
, 2001 We show that the so-called 'Petri nets are monoids' approach initiated by Meseguer and Montanari can be extended from ordinary place/transition Petri nets to contextual nets by considering suitable non-free monoids of places.
SASSONE V. +5 more
core +2 more sources
Nature Communications, 2018 Brain tumours are associated with epilepsy. Here the authors show, using a mouse model, that the degradation of perineuronal nets around fast spiking interneurons near the tumour contribute to seizures by increasing their membrane capacitance and firing.
Bhanu P. Tewari +5 more
doaj +1 more source
Cross-species conservation in the regulation of parvalbumin by perineuronal nets
Frontiers in Neural Circuits, 2023 Parvalbumin (PV) neurons play an integral role in regulating neural dynamics and plasticity. Therefore, understanding the factors that regulate PV expression is important for revealing modulators of brain function. While the contribution of PV neurons to
Angela S. Wang +12 more
doaj +1 more source
Advanced Science, EarlyView.Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang +11 more
wiley +1 more source