Results 11 to 20 of about 124,158 (160)

Primary cilia are required for the persistence of memory and stabilization of perineuronal nets

iScience, 2021
Summary: It is well established that the formation of episodic memories requires multiple hippocampal mechanisms operating on different time scales.
Vladimir Jovasevic, Hui Zhang, Farahnaz Sananbenesi, Anita L. Guedea, Kizhake V. Soman, John E. Wiktorowicz, Andre Fischer, Jelena Radulovic   +7 more
doaj   +2 more sources

Distribution of N-Acetylgalactosamine-Positive Perineuronal Nets in the Macaque Brain: Anatomy and Implications [PDF]

Neural Plasticity, 2016
Perineuronal nets (PNNs) are extracellular molecules that form around neurons near the end of critical periods during development. They surround neuronal cell bodies and proximal dendrites.
Adrienne L. Mueller, Adam Davis, Samantha Sovich, Steven S. Carlson, Farrel R. Robinson   +4 more
doaj   +2 more sources

The Role of Cerebellar Intrinsic Neuronal Excitability, Synaptic Plasticity, and Perineuronal Nets in Eyeblink Conditioning

Biology
Evidence is strong that, in addition to fine motor control, there is an important role for the cerebellum in cognition and emotion. The deep nuclei of the mammalian cerebellum also contain the highest density of perineural nets—mesh-like structures that ...
Bernard G. Schreurs, Deidre E. O’Dell, Desheng Wang   +2 more
doaj   +2 more sources

4-Methylumbelliferone Restores Age-Related Changes in Perineuronal Nets, Memory, and Neuroinflammation. [PDF]

Glia
Brain aging alters perineuronal nets and neuroinflammation. 4‐methylumbelliferone reversed these aging‐associated changes. 4‐methylumbelliferone reduced age‐associated cognitive decline. Six months of chronic oral treatment was well tolerated. ABSTRACT Aging‐associated cognitive decline is closely linked to dysregulated glial activity and chronic ...
Cimpean A, Mizerakova J, Martinez-Varea N, Marekova D, Machova Urdzikova L, Fawcett JW, Jendelova P, Kwok JCF.   +7 more
europepmc   +2 more sources

Selective dysfunction of fast-spiking inhibitory interneurons and disruption of perineuronal nets in a tauopathy mouse model

iScience, 2023
Summary: In Alzheimer’s disease (AD), network hyperexcitability is frequently observed and associated with subsequent cognitive impairment. Dysfunction of inhibitory interneurons (INs) is thought to be one of the key biological mechanisms of ...
Takehiro Kudo, Hiroyuki Takuwa, Manami Takahashi, Takuya Urushihata, Masafumi Shimojo, Kazuaki Sampei, Mitsugu Yamanaka, Yutaka Tomita, Naruhiko Sahara, Tetsuya Suhara, Makoto Higuchi   +10 more
doaj   +1 more source

Perineuronal Nets Protect Fast-Spiking Interneurons Against Oxidative Stress

, 2023
A hallmark of schizophrenia pathophysiology is the dysfunction of cortical inhibitory GABA neurons expressing parvalbumin, which are essential for coordinating neuronal synchrony during various sensory and cognitive tasks. The high metabolic requirements
Do, Kim Q., Kraftsik, Rudolf, Morishita, Hirofumi, Cabungcal, Jan-Harry, Steullet, Pascal, Cuenod, Michel, Hensch, Takao   +6 more
core   +1 more source

Postnatal development of the microstructure of cortical GABAergic synapses and perineuronal nets requires sensory input [PDF]

, 2022
The brain synaptic circuitry is formed as a result of pre-defined genetic programs and sensory experience during postnatal development. Perineuronal nets ensheath synaptic boutons and control several crucial features of the synapse physiology.
Fedosimova S., Dvoeglazova A., Titova A., Aganov A., Osin Y., Lipachev N., Arnst N., Mavlikeev M., Paveliev M., Shaikhutdinov N., Kiyasov A., Melnikova A., Kochneva A.   +12 more
core   +3 more sources

Synaptic Hyaluronan Synthesis and CD44-Mediated Signaling Coordinate Neural Circuit Development

Cells, 2021
The hyaluronan-based extracellular matrix is expressed throughout nervous system development and is well-known for the formation of perineuronal nets around inhibitory interneurons.
Emily S. Wilson, Karen Litwa
doaj   +1 more source

Perineuronal Nets and Metal Cation Concentrations in the Microenvironments of Fast-Spiking, Parvalbumin-Expressing GABAergic Interneurons: Relevance to Neurodevelopment and Neurodevelopmental Disorders

Biomolecules, 2021
Because of their abilities to catalyze generation of toxic free radical species, free concentrations of the redox reactive metals iron and copper are highly regulated.
Jessica A. Burket, Jason D. Webb, Stephen I. Deutsch   +2 more
doaj   +1 more source

Beta3Gn-T7 Is a Keratan Sulfate β1,3 N-Acetylglucosaminyltransferase in the Adult Brain

Frontiers in Neuroanatomy, 2022
Keratan sulfate (KS) glycan is covalently attached to a core protein of proteoglycans. KS is abundant in neuropils and presents densely in close proximity to the perineuronal region of the perineuronal net-positive neurons in the adult brain under ...
Yoshiko Takeda-Uchimura, Kazuchika Nishitsuji, Midori Ikezaki, Tomoya O. Akama, Yoshito Ihara, Fabrice Allain, Kenji Uchimura   +6 more
doaj   +1 more source