Distribution of Perineuronal Nets in the Adult Rat Neocortex [PDF]
Somatosens Mot ResPerineuronal nets (PNNs) are specialised extracellular matrix structures of the central nervous system that predominantly surround inhibitory interneurons.
Kumarie Budhu +4 more
semanticscholar +4 more sources
Perineuronal nets stabilize the grid cell network [PDF]
Nature Communications, 2021 Perineuronal nets may stabilize synaptic connections. Here, the authors show that removal of perineuronal nets disrupts both the temporal and spatial organization of grid cell firing.
Ane Charlotte Christensen +7 more
doaj +6 more sources
Shock-Induced Damage Mechanism of Perineuronal Nets [PDF]
Biomolecules, 2021 The perineuronal net (PNN) region of the brain’s extracellular matrix (ECM) surrounds the neural networks within the brain tissue. The PNN is a protective net-like structure regulating neuronal activity such as neurotransmission, charge balance, and ...
Khandakar Abu Hasan Al Mahmud +3 more
doaj +4 more sources
Caught in the Net: Perineuronal Nets and Addiction [PDF]
Neural Plasticity, 2016 Exposure to drugs of abuse induces plasticity in the brain and creates persistent drug-related memories. These changes in plasticity and persistent drug memories are believed to produce aberrant motivation and reinforcement contributing to addiction ...
Megan Slaker +2 more
doaj +4 more sources
Chronic fluoxetine modulates perineuronal nets and inhibitory neuronal function in relation to behavioral outcomes [PDF]
IBRO Neurosci RepChronic fluoxetine administration has been reported to enhance neural plasticity in the adult brain, but the underlying structural correlates remain incompletely understood.
Hiroshi Ueno +8 more
semanticscholar +2 more sources
S-ketamine relieves neuropathic pain by inhibiting microglia phagocytosis of the perineuronal nets [PDF]
Sci RepPerineurial network (PNN) is a special extracellular matrix structure in the central nervous system, and its alterations are associated with the pain hypersensitivity.
Xu-li Yang +11 more
semanticscholar +2 more sources
Selenium deficiency impedes maturation of parvalbumin interneurons, perineuronal nets, and neural network activity [PDF]
Redox BiolSelenoproteins are fundamental players in redox signaling that are essential for proper brain development and function. They are indispensable for the vitality of GABAergic parvalbumin-expressing interneurons (PVIs), a cell type characterized by fast ...
Alexandru R Sasuclark +5 more
semanticscholar +2 more sources
Glycosaminoglycan sugar side chains on perineuronal nets in the fastigial nucleus regulate motor skills [PDF]
iScienceSummary Perineuronal nets (PNNs), composed primarily of chondroitin sulfate proteoglycans with core proteins and glycosaminoglycan (GAG) side chains, are specialized extracellular matrices that modulate synaptic transmission.
Man Han +5 more
semanticscholar +2 more sources
Differential impacts of germline and adult aggrecan knockout in PV+ neurons on perineuronal nets and PV+ neuronal function [PDF]
Mol PsychiatryPerineuronal nets (PNNs) are a condensed form of extracellular matrix primarily found around parvalbumin-expressing (PV+) interneurons. The postnatal maturation of PV+ neurons is accompanied with the formation of PNNs and reduced plasticity.
Sverre Grødem +9 more
semanticscholar +2 more sources
Targeting CA2 Perineuronal Nets Restores Recognition Memory and Theta Oscillations in Aged Mice [PDF]
Aging CellRemembering familiar versus novel stimuli is fundamental to survival, but it is compromised in several neurodegenerative disorders where aging is a key factor. Although the components of the extracellular matrix (ECM) have been suggested to be implicated
Sonam Fathima Mehak +5 more
semanticscholar +2 more sources