Results 11 to 20 of about 3,965 (209)

Caught in the Net: Perineuronal Nets and Addiction [PDF]

Neural Plasticity, 2016
Exposure to drugs of abuse induces plasticity in the brain and creates persistent drug-related memories. These changes in plasticity and persistent drug memories are believed to produce aberrant motivation and reinforcement contributing to addiction ...
Megan Slaker, Jordan M. Blacktop, Barbara A. Sorg   +2 more
doaj   +5 more sources

Distribution of N-Acetylgalactosamine-Positive Perineuronal Nets in the Macaque Brain: Anatomy and Implications [PDF]

Neural Plasticity, 2016
Perineuronal nets (PNNs) are extracellular molecules that form around neurons near the end of critical periods during development. They surround neuronal cell bodies and proximal dendrites.
Adrienne L. Mueller, Adam Davis, Samantha Sovich, Steven S. Carlson, Farrel R. Robinson   +4 more
doaj   +2 more sources

The Role of Cerebellar Intrinsic Neuronal Excitability, Synaptic Plasticity, and Perineuronal Nets in Eyeblink Conditioning

Biology
Evidence is strong that, in addition to fine motor control, there is an important role for the cerebellum in cognition and emotion. The deep nuclei of the mammalian cerebellum also contain the highest density of perineural nets—mesh-like structures that ...
Bernard G. Schreurs, Deidre E. O’Dell, Desheng Wang   +2 more
doaj   +2 more sources

Perineuronal Nets’ Role in Metabolism

American Journal of Physiology-Endocrinology and Metabolism
Perineuronal nets (PNNs), specialized extracellular matrix (ECM) structures that envelop neurons, have recently been recognized as key players in the regulation of metabolism.
Chen, Lulu, Xu, Yong, Song, Beite, Zeng, Tianshu, Zhang, Nan, Du, Li, Bai, Peng   +6 more
core   +3 more sources

Perineuronal Nets and Their Role in Synaptic Homeostasis [PDF]

International Journal of Molecular Sciences, 2019
Extracellular matrix (ECM) molecules that are released by neurons and glial cells form perineuronal nets (PNNs) and modulate many neuronal and glial functions.
Anna Lubkowska, Magdalena Gąssowska-Dobrowolska, Izabela Gutowska, Dariusz Jeżewski, Marta Fabiańska, Klaudyna Kojder, Mateusz Bosiacki   +6 more
core   +3 more sources

Expression of aggrecan components in perineuronal nets in the mouse cerebral cortex

IBRO Reports, 2018
Specific regions of the cerebral cortex are highly plastic in an organism’s lifetime. It is thought that perineuronal nets (PNNs) regulate plasticity, but labeling for Wisteria floribunda agglutinin (WFA), which is widely used to detect PNNs, is observed
Hiroshi Ueno, Kazuki Fujii, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Shozo Aoki, Motoi Okamoto, Takeshi Ishihara, Keizo Takao   +9 more
doaj   +2 more sources

Hypothalamic Perineuronal Nets Are Regulated by Sex and Dietary Interventions [PDF]

Frontiers in Physiology, 2021
Perineuronal nets (PNNs) are widely present in the hypothalamus, and are thought to provide physical protection and ion buffering for neurons and regulate their synaptic plasticity and intracellular signaling.
Nan Zhang, Nan Zhang, Nan Zhang, Zili Yan, Hailan Liu, Meng Yu, Yang He, Hesong Liu, Chen Liang, Longlong Tu, Lina Wang, Na Yin, Junying Han, Nikolas Scarcelli, Yongjie Yang, Chunmei Wang, Tianshu Zeng, Tianshu Zeng, Lu-Lu Chen, Lu-Lu Chen, Yong Xu, Yong Xu   +21 more
doaj   +4 more sources

Perineuronal Nets Protect Fear Memories from Erasure

Science, 2009
In adult animals, fear conditioning induces a permanent memory that is resilient to erasure by extinction. In contrast, during early postnatal development, extinction of conditioned fear leads to memory erasure, suggesting that fear memories are actively
Caroni, P., Herry, C., Luthi, A., Gogolla, N.   +3 more
core   +6 more sources

Perineuronal Nets and CNS Plasticity and Repair [PDF]

Neural Plasticity, 2016
The extracellular matrix (ECM) of the nervous system regulates numerous events during development, from neurogenesis and gliogenesis to circuitry formation, as well as in adulthood, affecting damage responses, plasticity, and regeneration. Substantial changes in the quantity and the composition of ECM occur during development.
Daniela Carulli, Jessica C. F. Kwok, Tommaso Pizzorusso   +2 more
doaj   +6 more sources

Perineuronal Net Dynamics in the Pathophysiology of Epilepsy [PDF]

Epilepsy Currents, 2021
Perineuronal nets (PNNs) are condensed extracellular matrix (ECM) assemblies of polyanionic chondroitin sulfate proteoglycans, hyaluronan, and tenascins that primarily wrap around GABAergic parvalbumin (PV) interneurons. During development, PNN formation terminates the critical period of neuroplasticity, a process that can be reversed by experimental ...
Lata Chaunsali, Bhanu P. Tewari, Harald Sontheimer   +2 more
openaire   +3 more sources