Results 21 to 30 of about 1,449 (148)

Degradation of perineuronal nets in hippocampal CA2 explains the loss of social cognition memory in Alzheimer's disease. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Loss of social cognition memory impairs Alzheimer's disease (AD) patients to recognize family members, friends, and caregivers. We investigate the role of perineuronal nets (PNNs), specialized coats of extracellular matrix around hippocampal CA2 neurons in AD‐associated social memory impairments.
Chaunsali L, Li J, Fleischel E, Prim CE, Kasprzak I, Jiang S, Hou S, Escalante M, Cope EC, Olsen ML, Tewari BP, Sontheimer H.   +11 more
europepmc   +2 more sources

The Functional Epididymal Amyloid Cystatin-Related Epididymal Spermatogenic (CRES) is a Component of the Mammalian Brain Extracellular Matrix. [PDF]

J Neurosci Res
This study investigated if the epididymal amyloid CRES (cystatin‐related epididymal spermatogenic) is present in the male and female mammalian brain. CRES is expressed by hippocampal astrocytes, CA2 and CA3 neurons, and exhibits amyloid properties in the extracellular matrix.
Gomez A, Tran UT, Grozdanov PN, Cornwall GA.   +3 more
europepmc   +2 more sources

Cortical fast-spiking parvalbumin interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts8, Adamts15 and Neprilysin. [PDF]

, 2014
The in situ hybridization Allen Mouse Brain Atlas was mined for proteases expressed in the somatosensory cerebral cortex. Among the 480 genes coding for protease/peptidases, only four were found enriched in cortical interneurons: Reln coding for reelin ...
A Bernard, A Karagiannis, A Savoye, A Urban, B Rudy, BW Okaty, CL Thompson, CN Brocker, CN Pfeffer, D Wang, DA Lewis, Ed S Lein, ES Lein, G Fattorini, GA Ascoli, GW Huntley, H Taniguchi, J Helm, J Rossier, J-H Cabungcal, JA Cardin, JF Zander, JH Cabungcal, JH Cabungcal, JR Glausier, K Do, KA Giamanco, L Verret, M Cuénod, M Hawrylycz, M Schönlau, MR Celio, N Iwata, NN Nalivaeva, Q Perrenoud, Q Perrenoud, RY Tsien, S Berretta, S Rivera, SA Mauney, T Gallopin, T Pizzorusso, V Nagy, VS Sohal   +43 more
core   +2 more sources

Postnatal development of the microstructure of cortical GABAergic synapses and perineuronal nets requires sensory input [PDF]

, 2022
The brain synaptic circuitry is formed as a result of pre-defined genetic programs and sensory experience during postnatal development. Perineuronal nets ensheath synaptic boutons and control several crucial features of the synapse physiology.
Aganov, Albert, Arnst, Nikita, Dvoeglazova, Anastasia, Fedosimova, Svetlana, Kiyasov, Andrei, Kochneva, Anastasia, Lipachev, Nikita, Mavlikeev, Mikhail, Melnikova, Anastasia, Osin, Yuri, Paveliev, Mikhail, Shaikhutdinov, Nurislam, Titova, Angelina   +12 more
core   +1 more source

Chronic Toxoplasma gondii infection contributes to perineuronal nets impairment in the primary somatosensory cortex

Parasites & Vectors, 2022
Toxoplasma gondii is able to manipulate the host immune system to establish a persistent and efficient infection, contributing to the development of brain abnormalities with behavioral repercussions.
Ramayana Morais de Medeiros Brito, Ywlliane da Silva Rodrigues Meurer, Jully Anne Lemos Batista, Andréa Lima de Sá, Cássio Ricardo de Medeiros Souza, Janeusa Trindade de Souto, Valter Ferreira de Andrade-Neto   +6 more
doaj   +1 more source

Neonatal Zika virus infection causes transient perineuronal net degradation

Frontiers in Cellular Neuroscience, 2023
Perineuronal nets (PNNs) form a specialized extracellular matrix that predominantly surrounds parvalbumin (PV)-expressing GABAergic inhibitory interneurons and help regulate neuronal activity. Their formation early in the postnatal period is regulated by
Kaliroi Engel, Ha-Na Lee, Bhanu P. Tewari, Aaron P. Lewkowicz, Derek D. C. Ireland, Mohanraj Manangeeswaran, Daniela Verthelyi   +6 more
doaj   +1 more source

Reconsideration of the Semaphorin-3A Binding Motif Found in Chondroitin Sulfate Using Galnac4s-6st-Knockout Mice

Biomolecules, 2020
The chondroitin sulfate (CS)-rich dense extracellular matrix surrounding neuron cell bodies and proximal dendrites in a mesh-like structure is called a perineuronal net (PNN).
Satomi Nadanaka, Shinji Miyata, Bai Yaqiang, Jun-ichi Tamura, Osami Habuchi, Hiroshi Kitagawa   +5 more
doaj   +1 more source

60404 HIV Tat Induced Neuroinflammation

Journal of Clinical and Translational Science, 2021
IMPACT: Demonstrate the role of astrocyte released MMPs in response to pathogenic HIV protein Tat. OBJECTIVES/GOALS: In the presence of the pathogenic HIV protein Tat, astrocytes have been demonstrated to adopt an inflammatory phenotype as well as ...
Sean Carey, Kathleen Maguire-Zeiss
doaj   +1 more source

Perineuronal nets enhance the excitability of fast-spiking neurons [PDF]

, 2016
© The Author(s), 2016. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in eNeuro 3 (2016): e0112-16.2016, doi:10.1523/ENEURO.0112-16.2016.Perineuronal nets (PNNs) are ...
Balmer, Timothy
core   +1 more source

Neuronal Pentraxin 2 Binds PNNs and Enhances PNN Formation

Neural Plasticity, 2019
The perineuronal net (PNN) is a mesh-like proteoglycan structure on the neuronal surface which is involved in regulating plasticity. The PNN regulates plasticity via multiple pathways, one of which is direct regulation of synapses through the control of ...
Heleen M. Van’t Spijker, Dáire Rowlands, Jean Rossier, Barbara Haenzi, James W. Fawcett, Jessica C. F. Kwok   +5 more
doaj   +1 more source