Results 21 to 30 of about 882 (110)

Neuronal Pentraxin 2 Binds PNNs and Enhances PNN Formation

Neural Plasticity, 2019
The perineuronal net (PNN) is a mesh-like proteoglycan structure on the neuronal surface which is involved in regulating plasticity. The PNN regulates plasticity via multiple pathways, one of which is direct regulation of synapses through the control of ...
Heleen M. Van’t Spijker, Dáire Rowlands, Jean Rossier, Barbara Haenzi, James W. Fawcett, Jessica C. F. Kwok   +5 more
doaj   +1 more source

Maturation of PNN and ErbB4 Signaling in Area CA2 during Adolescence Underlies the Emergence of PV Interneuron Plasticity and Social Memory

Cell Reports, 2019
Summary: Adolescence is a vulnerable period characterized by major cognitive changes. The mechanisms underlying the emergence of new cognitive functions are poorly understood.
Soledad Domínguez, Christophe Clément Rey, Ludivine Therreau, Aurélien Fanton, Dominique Massotte, Laure Verret, Rebecca Ann Piskorowski, Vivien Chevaleyre   +7 more
doaj   +1 more source

Proteolytic Remodeling of Perineuronal Nets: Effects on Synaptic Plasticity and Neuronal Population Dynamics

Neural Plasticity, 2018
The perineuronal net (PNN) represents a lattice-like structure that is prominently expressed along the soma and proximal dendrites of parvalbumin- (PV-) positive interneurons in varied brain regions including the cortex and hippocampus.
P. Lorenzo Bozzelli, Seham Alaiyed, Eunyoung Kim, Sonia Villapol, Katherine Conant   +4 more
doaj   +1 more source

Effect of Shock-Induced Cavitation Bubble Collapse on the damage in the Simulated Perineuronal Net of the Brain

Scientific Reports, 2017
The purpose of this study is to conduct modeling and simulation to understand the effect of shock-induced mechanical loading, in the form of cavitation bubble collapse, on damage to the brain’s perineuronal nets (PNNs).
Yuan-Ting Wu, Ashfaq Adnan
doaj   +1 more source

Spiny and Non-spiny Parvalbumin-Positive Hippocampal Interneurons Show Different Plastic Properties

Cell Reports, 2019
Summary: Dendritic spines control synaptic transmission and plasticity by augmenting post-synaptic potentials and providing biochemical compartmentalization.
Angelica Foggetti, Gilda Baccini, Philipp Arnold, Thomas Schiffelholz, Peer Wulff   +4 more
doaj   +1 more source

Enriched housing enhances recovery of limb placement ability and reduces aggrecan-containing perineuronal nets in the rat somatosensory cortex after experimental stroke. [PDF]

PLoS ONE, 2014
Stroke causes life long disabilities where few therapeutic options are available. Using electrical and magnetic stimulation of the brain and physical rehabilitation, recovery of brain function can be enhanced even late after stroke. Animal models support
Alexandre Madinier, Miriana Jlenia Quattromani, Carin Sjölund, Karsten Ruscher, Tadeusz Wieloch   +4 more
doaj   +1 more source

Consumption of a High-Fat Diet Alters Perineuronal Nets in the Prefrontal Cortex

Neural Plasticity, 2018
A key factor in the development of obesity is the overconsumption of fatty foods, which, in addition to facilitating weight gain, alters neuronal structures within brain reward circuitry.
P. M. Dingess, J. H. Harkness, M. Slaker, Z. Zhang, S. S. Wulff, B. A. Sorg, T. E. Brown   +6 more
doaj   +1 more source

Layer-specific expression of extracellular matrix molecules in the mouse somatosensory and piriform cortices

IBRO Reports, 2019
In the developing central nervous system (CNS), extracellular matrix (ECM) molecules have regulating roles such as in brain development, neural-circuit maturation, and synaptic-function control.
Hiroshi Ueno, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara   +7 more
doaj   +1 more source

A Role for Matrix Metalloproteases in Antidepressant Efficacy

Frontiers in Molecular Neuroscience, 2019
Major depressive disorder is a debilitating condition that affects approximately 15% of the United States population. Though the neurophysiological mechanisms that underlie this disorder are not completely understood, both human and rodent studies ...
Seham Alaiyed, Katherine Conant
doaj   +1 more source

Heparan sulfate and glycomimetics: Advances in synthesis and biological applications for post‐stroke neurorepair

Neuroprotection, EarlyView.
ECM, extracellular matrix; BDNF, brain‐derived neuroptrophic factor; FGF, fibroblast growth factor; VEGF, vascular endothelial growth factor. Abstract Heparan sulfate, a structurally diverse glycosaminoglycan that is abundant in the central nervous system (CNS), orchestrates essential processes fundamental to neural plasticity, neurorepair, and ...
Mozammel H. Bhuiyan, Madeleine J. Smith, Simon F. R. Hinkley, Andrew N. Clarkson   +3 more
wiley   +1 more source