Results 41 to 50 of about 885 (110)

Astrocytic Regulation of Aberrant Perineuronal Net Formation in Mecp2‐Null Neocortex

Journal of Neurochemistry, Volume 170, Issue 6, June 2026.
Early closure of the critical period of plasticity and precocious formation of perineuronal nets (PNNs) occur in Rett syndrome (RTT). PNNs are essential in the modulation of neuronal plasticity and brain maturation. We determined that PNNs structurally mature earlier in the Mecp2‐null RTT model mouse brain, and that Mecp2‐null mouse astrocytes play a ...
Ashis Sinha, Angelica M. Kowalchuk, Nasim Khatibi, Russell T. Matthews, Jessica L. MacDonald   +4 more
wiley   +1 more source

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, Volume 12, Issue 1, Page 65-85, Spring 2026.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

Prefrontal Cortex Dysfunction as a Precipitating Factor for Schizophrenia and Depression

Journal of Neurochemistry, Volume 170, Issue 3, March 2026.
Stress during adolescence or adulthood affects the ability of the prefrontal cortex (PFC) to adaptively regulate stress. Maladaptive adult stress leads to PFC hypofunction and a hypodopaminergic state in the medial, affect‐related ventral tegmental area (VTA), resulting in amotivation.
Daniela L. Uliana, Anthony A. Grace
wiley   +1 more source

Adrenarche as a regulator of sensitivity to early adversity

Journal of Neuroendocrinology, Volume 38, Issue 3, March 2026.
Abstract The human brain is highly sensitive to early adversity, which can have long‐term consequences for later mental health. It is also a time of rapid learning of social, motor and other skills, including language. It is proposed that pre‐adrenarche, the only epoch in human development in which cortisol is not accompanied by dehydroepiandrosterone (
J. Herbert
wiley   +1 more source

From Synaptic Plasticity and Critical Periods to Social Behavior and Stress: Getting to, and Staying in, CA2

Hippocampus, Volume 36, Issue 1, January 2026.
ABSTRACT Hippocampal Area CA2, with some exceptions, had long been neglected in in vivo studies, due largely to its small size, and in in vitro studies because of its general similarity to CA3 and CA1. Increasing evidence showing that CA2 was molecularly distinct led to the increased appreciation of CA2 as a separate region, and as such, that it likely
Serena M. Dudek
wiley   +1 more source

The Functional Epididymal Amyloid Cystatin‐Related Epididymal Spermatogenic (CRES) is a Component of the Mammalian Brain Extracellular Matrix

Journal of Neuroscience Research, Volume 104, Issue 1, January 2026.
This study investigated if the epididymal amyloid CRES (cystatin‐related epididymal spermatogenic) is present in the male and female mammalian brain. CRES is expressed by hippocampal astrocytes, CA2 and CA3 neurons, and exhibits amyloid properties in the extracellular matrix.
Alejandra Gomez, Uyen T. Tran, Petar N. Grozdanov, Gail A. Cornwall   +3 more
wiley   +1 more source

Selective Synaptic Remodeling in Rat Auditory and Visual Cortices Following Noise‐Induced Permanent Hearing Loss in Adulthood

Neural Plasticity, Volume 2026, Issue 1, 2026.
In adults with acquired hearing loss, cortical reorganization and cross‐modal plasticity critically influence the timing and outcomes of cochlear implantation. This study examined the effects of 2 weeks of bilateral auditory deprivation—induced by intense broadband noise—on the structure and gene expression in the primary auditory (A1) and visual (V1 ...
Miao Zhao, Yanjie Bai, Yaxin Yang, Na Li, You Zhou, Fernando Peña-Ortega   +5 more
wiley   +1 more source

The critical role of extracellular matrix in Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue S1, December 2025.
Abstract Background In central nervous system, all components are enveloped by the extracellular matrix (ECM), regulating microenvironmental homeostasis and neuronal development. The condensed cartilage‐like ECM called perineuronal nets (PNNs), mainly surrounding parvalbumin‐expressing (PV+) fast‐firing GABAergic interneurons, are crucial to synaptic ...
Xiaolei Zhu, Zhen Lan, Yun Xu
wiley   +1 more source

Role of perineuronal nets in Alzheimer's Disease‐associated social memory impairment

Alzheimer's &Dementia, Volume 21, Issue S1, December 2025.
Abstract Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting approximately 55 million people worldwide. Key pathological features of AD include the accumulation of beta‐amyloid plaques and hyperphosphorylated tau tangles.
Lata Chaunsali
wiley   +1 more source

Phagocytosis of aggrecan-positive perineuronal nets surrounding motor neurons by reactive microglia expressing MMP-9 in TDP-43Q331K ALS model mice

Neurobiology of Disease
Perineuronal nets (PNNs) are extracellular matrix structures that surround excitable neurons and their proximal dendrites. PNNs play an important role in neuroprotection against oxidative stress. Oxidative stress within motor neurons can act as a trigger
Sang Won Cheung, Emily F. Willis, David G. Simmons, Mark C. Bellingham, Peter G. Noakes   +4 more
doaj   +1 more source