Results 41 to 50 of about 1,449 (148)

Neuroinflammatory targets and treatments for epilepsy validated in experimental models [PDF]

, 2017
A large body of evidence that has accumulated over the past decade strongly supports the role of inflammation in the pathophysiology of human epilepsy.
Aronica, Eleonora, Bauer, Sebastian, Bozzi, Yuri, Caleo, Matteo, Dingledine, Raymond, Gorter, Jan A., Henshall, David C., Kaminski, Rafal M., Kaufer, Daniela, Koh, Sookyong, Lã¶scher, Wolfgang, Louboutin, Jean-pierre, Mishto, Michele, Norwood, Braxton A., Palma, Eleonora, Poulter, Michael O., Terrone, Gaetano, Vezzani, Annamaria   +17 more
core   +5 more sources

Consumption of a High-Fat Diet Alters Perineuronal Nets in the Prefrontal Cortex

Neural Plasticity, 2018
A key factor in the development of obesity is the overconsumption of fatty foods, which, in addition to facilitating weight gain, alters neuronal structures within brain reward circuitry.
P. M. Dingess, J. H. Harkness, M. Slaker, Z. Zhang, S. S. Wulff, B. A. Sorg, T. E. Brown   +6 more
doaj   +1 more source

Reduction in parvalbumin expression not loss of the parvalbumin-expressing GABA interneuron subpopulation in genetic parvalbumin and shank mouse models of autism [PDF]

, 2016
Background A reduction of the number of parvalbumin (PV)-immunoreactive (PV⁺) GABAergic interneurons or a decrease in PV immunoreactivity was reported in several mouse models of autism spectrum disorders (ASD). This includes Shank mutant mice, with SHANK
Filice, Federica, Schwaller, Beat, Sungur, Ayse Özge, Vörckel, Karl Jakob, Wöhr, Markus   +4 more
core   +1 more source

Fast oscillatory activity in the anterior cingulate cortex: dopaminergic modulation and effect of perineuronal net loss. [PDF]

, 2014
Dopamine release in the prefrontal cortex plays a critical role in cognitive function such as working memory, attention and planning. Dopamine exerts complex modulation on excitability of pyramidal neurons and interneurons, and regulates excitatory and ...
Cabungcal, J.H., Cuénod, M., Do, K.Q., Steullet, P.   +3 more
core   +1 more source

BDNF and JNK-signalling modulate cortical interneuron and perineuronal net development: implications for schizophrenia-linked 16p11.2 duplication syndrome [PDF]

, 2020
Schizophrenia is a neurodevelopmental disorder caused by the interaction of genetic and environmental risk factors. One of the strongest genetic risk variants is duplication of chr.16p11.2. Schizophrenia is characterised by cortical GABAergic interneuron
Morris, Brian J, Pratt, Judith A, Willis, Ashleigh   +2 more
core   +2 more sources

Altered excitatory-inhibitory balance within somatosensory cortex is associated with enhanced plasticity and pain sensitivity in a mouse model of multiple sclerosis [PDF]

, 2016
S1 IHC in pre-symptomatic and clinical-onset EAE: PV+ cell counts, PNN counts, and Iba-1+ microglia counts. A) Representative fluorescence photomicrographs of PV+ staining (low-mag) in S1 from control (CFA) and EAE animals at the pre-symptomatic stage (7–
Bradley J. Kerr, Fred Colbourne, Glen Baker, Gustavo Tenorio, Ian Winship, Jayalakshmi Caliaperumal, Jee Su Suh, John W. Paylor, Liam E. Potter   +8 more
core   +4 more sources

Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: A "central hub" in schizophrenia pathophysiology? [PDF]

, 2016
Accumulating evidence points to altered GABAergic parvalbumin-expressing interneurons and impaired myelin/axonal integrity in schizophrenia. Both findings could be due to abnormal neurodevelopmental trajectories, affecting local neuronal networks and ...
A. Monin, Abekawa, Atallah, Atkuri, Avshalumov, Back, Baker, Ballesteros, Bartos, Baud, Behrens, Behrens, Belforte, Bentsen, Berk, Berk, Beurdeley, Bilbo, Bodhinathan, Brenhouse, Bridges, Brown, Buckholtz, Buelna-Chontal, Bulut, Byne, Cabungcal, Cabungcal, Cabungcal, Cadet, Cai, Callahan, Cao, Cardin, Carlen, Carlson, Carmeli, Cavaliere, Chattopadhyaya, Chew, Choi, Clay, Cleland, Corcoba, Coyle, Cyr, D. Dwir, Dalmau, das Neves Duarte, Davis, Dell'Anna, Dickerson, Dityatev, Do, Do, Do, Do, Donato, Eluvathingal, Fan, Fan, Fan, Farokhnia, Farr, Fazzari, Fitzsimmons, Fournier, Fragoso, French, Fries, Fromer, Fuchs, Fukuda, Gandal, Garate, Gawryluk, Gokhale, Goldshmit, Gravina, Gulyas, Gysin, Gysin, Hakak, Hardingham, Harris, Harris, Harte, Hikida, Hof, Hoftman, Homayoun, Huang, Hwang, Ibi, Insel, J.H. Cabungcal, Jana, Javitt, Jenkins, Jiang, Jiang, Johnson, Jones, K.Q. Do, Kann, Kantrowitz, Katsel, Kaur, Kerns, Kettenmann, Kinney, Kirov, Kocsis, Koga, Kohr, Komitova, Korotkova, Krishnan, Krystal, Kulak, Kulak, Kyriakopoulos, Lante, Lataster, Lataster, Lavoie, Lavoie, Lazarewicz, Lewis, Leza, Li, Li, Lisman, Liu, Lodge, Lodge, Lucas, Lutgen, M. Cuenod, Makinodan, Makinodan, Mandal, Martins-de-Souza, Massi, Mauney, McGee, McNally, Mehta, Meiser, Meyer, Meyer, Meyer, Miyata, Mizrahi, Moller, Monin, Morishita, Morishita, Muller, Muller, Mustafa, Myin-Germeys, Myin-Germeys, O'Donnell, O'Donnell, Oorschot, Otte, P. O'Donnell, P. Steullet, Paintlia, Pantazopoulos, Papadia, Park, Patz, Penschuck, Pinteaux, Pitts, Poels, Potvin, Powell, Purcell, Rabinovic, Ray, Reddy, Robinson, Rodriguez-Santiago, Rotaru, Rouhinen, Roux, Saetre, Schiavone, Shirai, Sinn, Smith, Smyth, Sohal, Song, Stefansson, Steiner, Steullet, Steullet, Steullet, Steullet, Stevens, Stojkovic, Sullivan, Takahashi, Takao, Timms, Tkachev, Tosic, Tseng, Tseng, Uhlhaas, Uhlhaas, Umbricht, Uranova, Uranova, Uranova, Valko, van Berckel, Vinson, Walter, Wang, Wang, Wang, Wang, Wang, Wen, Whitford, Wulff, Yanagi, Yao, Yao, Zafarullah, Zhang, Zhang, Zhang   +237 more
core   +1 more source

Responses in fast-spiking interneuron firing rates to parameter variations associated with degradation of perineuronal nets [PDF]

, 2023
publishedVersio
Einevoll, Gaute, Fyhn, Marianne, Grødem, Sverre, Hafting, Torkel, Halnes, Geir, Hanssen, Kine Ødegård, Ness, Torbjørn V   +6 more
core   +2 more sources

A Role for Matrix Metalloproteases in Antidepressant Efficacy

Frontiers in Molecular Neuroscience, 2019
Major depressive disorder is a debilitating condition that affects approximately 15% of the United States population. Though the neurophysiological mechanisms that underlie this disorder are not completely understood, both human and rodent studies ...
Seham Alaiyed, Katherine Conant
doaj   +1 more source

Prenatal valproate exposure differentially affects parvalbumin-expressing neurons and related circuits in the cortex and striatum of mice [PDF]

, 2016
Autism spectrum disorders (ASD) comprise a number of heterogeneous neurodevelopmental diseases characterized by core behavioral symptoms in the domains of social interaction, language/communication and repetitive or stereotyped patterns of behavior ...
Filice, Federica, Lauber, Emanuel, Schwaller, Beat   +2 more
core   +1 more source