Results 41 to 50 of about 882 (110)

From Synaptic Plasticity and Critical Periods to Social Behavior and Stress: Getting to, and Staying in, CA2

Hippocampus, Volume 36, Issue 1, January 2026.
ABSTRACT Hippocampal Area CA2, with some exceptions, had long been neglected in in vivo studies, due largely to its small size, and in in vitro studies because of its general similarity to CA3 and CA1. Increasing evidence showing that CA2 was molecularly distinct led to the increased appreciation of CA2 as a separate region, and as such, that it likely
Serena M. Dudek
wiley   +1 more source

The Functional Epididymal Amyloid Cystatin‐Related Epididymal Spermatogenic (CRES) is a Component of the Mammalian Brain Extracellular Matrix

Journal of Neuroscience Research, Volume 104, Issue 1, January 2026.
This study investigated if the epididymal amyloid CRES (cystatin‐related epididymal spermatogenic) is present in the male and female mammalian brain. CRES is expressed by hippocampal astrocytes, CA2 and CA3 neurons, and exhibits amyloid properties in the extracellular matrix.
Alejandra Gomez, Uyen T. Tran, Petar N. Grozdanov, Gail A. Cornwall   +3 more
wiley   +1 more source

Selective Synaptic Remodeling in Rat Auditory and Visual Cortices Following Noise‐Induced Permanent Hearing Loss in Adulthood

Neural Plasticity, Volume 2026, Issue 1, 2026.
In adults with acquired hearing loss, cortical reorganization and cross‐modal plasticity critically influence the timing and outcomes of cochlear implantation. This study examined the effects of 2 weeks of bilateral auditory deprivation—induced by intense broadband noise—on the structure and gene expression in the primary auditory (A1) and visual (V1 ...
Miao Zhao, Yanjie Bai, Yaxin Yang, Na Li, You Zhou, Fernando Peña-Ortega   +5 more
wiley   +1 more source

The critical role of extracellular matrix in Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue S1, December 2025.
Abstract Background In central nervous system, all components are enveloped by the extracellular matrix (ECM), regulating microenvironmental homeostasis and neuronal development. The condensed cartilage‐like ECM called perineuronal nets (PNNs), mainly surrounding parvalbumin‐expressing (PV+) fast‐firing GABAergic interneurons, are crucial to synaptic ...
Xiaolei Zhu, Zhen Lan, Yun Xu
wiley   +1 more source

Role of perineuronal nets in Alzheimer's Disease‐associated social memory impairment

Alzheimer's &Dementia, Volume 21, Issue S1, December 2025.
Abstract Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting approximately 55 million people worldwide. Key pathological features of AD include the accumulation of beta‐amyloid plaques and hyperphosphorylated tau tangles.
Lata Chaunsali
wiley   +1 more source

Intervertebral Disc Proteoglycans: Multifunctional Tissue Stabilizing and Instructional Cell Regulatory Proteins That Control Tissue Homeostasis

JOR SPINE, Volume 8, Issue 4, December 2025.
Matrix and cell‐associated proteoglycans are important tissue‐stabilizing, weight‐bearing, and tension‐resisting proteins in the intervertebral disc. Their glycosaminoglycan components have growth factor binding and cell‐instructive properties that allow cells to regulate tissue composition and function.
James Melrose
wiley   +1 more source

Environmental Enrichment Suppresses Food Seeking and Increases Inhibitory Interneuron Excitability While Decreasing Corticothalamic Neuronal Recruitment in the Prelimbic Cortex

European Journal of Neuroscience, Volume 62, Issue 10, November 2025.
Environmental enrichment (EE) reduces cue‐evoked sucrose seeking and is accompanied by enhanced inhibitory interneuron excitability and suppressed corticothalamic recruitment in the prelimbic cortex. Using brain slice electrophysiology, retrograde tracing and Fos assays, we show that EE increases baseline excitability of interneurons but not pyramidal ...
Kate Z. Peters, Romarua Agbude, Oliver G. Steele, Nobuyoshi Suto, Eisuke Koya   +4 more
wiley   +1 more source

Crosstalk Between Astrocytes and Inhibitory Neurons During Maturation: Emerging Mechanisms and Functional Implications

Journal of Neurochemistry, Volume 169, Issue 11, November 2025.
In this review, we discuss the development and maturation of inhibitory neurons and astrocytes and how early developmental activity in the brain might promote the interactions between these cell types. Early in development, excitatory neurons are the first to emerge.
Niina Lehti Tauriala, Vered Kellner
wiley   +1 more source

Phagocytosis of aggrecan-positive perineuronal nets surrounding motor neurons by reactive microglia expressing MMP-9 in TDP-43Q331K ALS model mice

Neurobiology of Disease
Perineuronal nets (PNNs) are extracellular matrix structures that surround excitable neurons and their proximal dendrites. PNNs play an important role in neuroprotection against oxidative stress. Oxidative stress within motor neurons can act as a trigger
Sang Won Cheung, Emily F. Willis, David G. Simmons, Mark C. Bellingham, Peter G. Noakes   +4 more
doaj   +1 more source

Postoperative loss of perineuronal nets in the hippocampal CA1 region results in memory consolidation deficits

Brain Research Bulletin
Postoperative cognitive dysfunction (POCD) is a common postoperative neurological complication, with memory consolidation deficits being one of its prominent features.
Zun-sai Feng, Jiang-nan Wu, Gui-cheng Wang, Zi-qing Xu, Yan-jing Guo, Shi-yu Hao, Gong-ming Wang, Meng-yuan Zhang   +7 more
doaj   +1 more source