Results 51 to 60 of about 1,449 (148)

Chronic silencing of subsets of cortical layer 5 pyramidal neurons has a long‐term influence on the laminar distribution of parvalbumin interneurons and the perineuronal nets

Journal of Anatomy, Volume 246, Issue 4, Page 479-504, April 2025.
Chronic silencing of subsets of layer 5 projection neurons has distinct effects on the laminar distribution of PV interneurons and the perineuronal nets in the adult primary motor and somatosensory cortex. Abstract Neural networks are established throughout cortical development, which require the right ratios of glutamatergic and GABAergic neurons ...
Florina P. Szabó, Veronika Sigutova, Anna M. Schneider, Anna Hoerder‐Suabedissen, Zoltán Molnár   +4 more
wiley   +1 more source

Electroacupuncture Modulation of Chondroitin Sulfate Glycosaminoglycan Promotes the Repair of Damaged Spinal Cord in Rats

Journal of Integrative Neuroscience
Background: The perineuronal net (PNN) is an important extracellular environment around parvalbumin interneuron (PV IN) in the spinal cord.
Bowen Chen, Rong Hu, Xingying Wu, Mengting Shi, Yi Chen, Jieqi Zhang, Yi Huang, Xihan Ying, Dexiong Han, Ruijie Ma   +9 more
doaj   +1 more source

Targeting CA2 Perineuronal Nets Restores Recognition Memory and Theta Oscillations in Aged Mice. [PDF]

Aging Cell
Targeting CA2 perineuronal nets restores social/non‐social recognition memory and theta oscillations in aged mice: Aged mice displayed deficits in both social and object recognition memory, which were accompanied by enhanced perineuronal nets (PNNs) density and reduced theta power in the dCA2 region.
Mehak SF, Shivakumar AB, Jijimon F, Gupta A, Pillai VG, Gangadharan G.   +5 more
europepmc   +2 more sources

A neural extracellular matrix-based method for in vitro hippocampal neuron culture and dopaminergic differentiation of neural stem cells [PDF]

, 2013
BACKGROUND: The ability to recreate an optimal cellular microenvironment is critical to understand neuronal behavior and functionality in vitro.
Adolfo López de Munain, Ander Izeta, Antonio G García, Fabio Cavaliere, José Álava, Marcos Maroto, Neia Naldaiz-Gastesi, Patricia García-Parra   +7 more
core   +3 more sources

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, Volume 12, Issue 1, Page 65-85, Spring 2026.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

Structural changes in perineuronal nets and their perforating GABAergic synapses precede motor coordination recovery post stroke [PDF]

, 2023
Background Stroke remains one of the leading causes of long-term disability worldwide, and the development of effective restorative therapies is hindered by an incomplete understanding of intrinsic brain recovery mechanisms.
Dzyubenko, Egor, Hermann, Dirk M., Labus, Patrick, Sardari, Maryam, Schmermund, Ben, Tokmak, Erdin, Willig, Katrin, Yin, Dongpei   +7 more
core   +2 more sources

Aberrant perineuronal nets alter spinal circuits, impair motor function, and increase plasticity [PDF]

, 2022
Altres ajuts: acords transformatius de la UABPerineuronal nets (PNNs) are a specialized extracellular matrix that have been extensively studied in the brain.
Canal Capdevila, Carla, Fouad, K, Hidalgo Pareja, Juan, Navarro, X. (Xavier), Penas Pérez, Clara, Sánchez-Ventura, Judith, Torres Espín, Abel, Udina i Bonet, Esther, Universitat Autònoma de Barcelona. Institut de Neurociències   +8 more
core   +1 more source

Adrenarche as a regulator of sensitivity to early adversity

Journal of Neuroendocrinology, Volume 38, Issue 3, March 2026.
Abstract The human brain is highly sensitive to early adversity, which can have long‐term consequences for later mental health. It is also a time of rapid learning of social, motor and other skills, including language. It is proposed that pre‐adrenarche, the only epoch in human development in which cortisol is not accompanied by dehydroepiandrosterone (
J. Herbert
wiley   +1 more source

Cell therapy for spinal cord injury with Olfactory Ensheathing Glia Cells (OECs) [PDF]

, 2018
This is the peer reviewed version of the following article: Gómez RM, Sánchez MY, Portela-Lomba M, et al. Cell therapy for spinal cord injury with olfactoryensheathing glia cells (OECs). Glia. 2018;00:1–35 which has been published in final form at GLIA
Barreto, George E., Ghotme, Kemel, Gómez, Rosa M., Moreno-Flores, M. Teresa, Portela-Lomba, María, Sierra, Javier, Sánchez, Magdy Y.   +6 more
core   +2 more sources

From Synaptic Plasticity and Critical Periods to Social Behavior and Stress: Getting to, and Staying in, CA2

Hippocampus, Volume 36, Issue 1, January 2026.
ABSTRACT Hippocampal Area CA2, with some exceptions, had long been neglected in in vivo studies, due largely to its small size, and in in vitro studies because of its general similarity to CA3 and CA1. Increasing evidence showing that CA2 was molecularly distinct led to the increased appreciation of CA2 as a separate region, and as such, that it likely
Serena M. Dudek
wiley   +1 more source