Results 71 to 80 of about 1,449 (148)

Targeting Oxidative Stress and Aberrant Critical Period Plasticity in the Developmental Trajectory to Schizophrenia [PDF]

, 2017
Schizophrenia is a neurodevelopmental disorder reflecting a convergence of genetic risk and early life stress. The slow progression to first psychotic episode represents both a window of vulnerability as well as opportunity for therapeutic intervention ...
Cuenod, Michel, Do, Kim Q., Hensch, Takao K.   +2 more
core  

The Effect of Mild Traumatic Brain Injury on Perineuronal Nets Surrounding Neocortical Parvalbumin Interneurons [PDF]

, 2023
Mild traumatic brain injury (mTBI) is an extremely common affliction with an estimated 42 million people being affected by it worldwide each year. It can lead to a range of long-term chronic issues and the underlying pathology is not well understood ...
Lowman, Olivia
core   +1 more source

Tumor‐related epilepsy in glioma: A multidisciplinary overview

Epilepsia, Volume 66, Issue 10, Page 3621-3641, October 2025.
Abstract Seizures are a common and challenging symptom in brain tumors, affecting approximately 60% of patients. Tumor‐related epilepsy (TRE) in glioma patients requires personalized and dynamic management in a multidisciplinary environment, especially for its intricate pathophysiology and unpredictable disease evolution. This investigation provides an
Roberto Michelucci, Giada Pauletto, Antonio Silvani, Elena Pasini, Tamara Ius, Matteo Martinoni, Carlo Alberto Castioni, Andrea Salmaggi, Sofia Asioli, Marta Maschio, Giuseppe Minniti, Enrico Franceschi, Flavio Villani, Roberta Rudà, Eleonora Aronica, the Italian Multidisciplinary Group for Tumor Epilepsy, Paolo Vitali, Damiano Balestrini, Elisa D’Angelo, Lorenzo Bello, Marco Rossi, Marta Padovan, Anna Teresa Giallonardo, Carlo di Bonaventura, Francesco Toni, Angela La Neve, Simona Rizzato, Matteo Pugnaghi, Marco Vindigni, Carmelo Sturiale   +29 more
wiley   +1 more source

Antibody recognizing 4-sulfated chondroitin sulfate proteoglycans restores memory in tauopathy-induced neurodegeneration [PDF]

, 2017
Chondroitin sulfate proteoglycans (CSPGs) are the main active component of perineuronal nets (PNNs). Digestion of the glycosaminoglycan chains of CSPGs with chondroitinase ABC or transgenic attenuation of PNNs leads to prolongation of object recognition ...
Alves, João Nuno, Bussey, Timothy, Fawcett, James W, Hilton, Sam, Kitagawa, Hiroshi, Kwok, Jessica CF, Matthews, Russell T, Saksida, Lisa M, Spillantini, Maria Grazia, Yang, Sujeong   +9 more
core   +2 more sources

Medial septum parvalbumin‐expressing inhibitory neurons are impaired in a mouse model of Dravet syndrome

Epilepsia, Volume 66, Issue 10, Page 4053-4065, October 2025.
Abstract Objective Dravet syndrome (DS) is a severe neurodevelopmental disorder caused by pathogenic variants in the SCN1A gene, which encodes the voltage‐gated sodium channel Nav1.1 α subunit. Experiments in animal models of DS—including the haploinsufficient Scn1a+/− mouse—have identified impaired excitability of interneurons in the hippocampus and ...
Limei Zhu, Yiannos Demetriou, Joseph Barden, Juan Disla, Meiling Zhao, Joanna Mattis   +5 more
wiley   +1 more source

Molekuláris mechanizmusok vizsgálata a vestibularis rendszer fejlődése, regenerációja és plaszticitása során = Investigation of molecular mechanisms in the development, regeneration and plasticity of vestibular system [PDF]

, 2012
Csirkeembriók gerincvelőjében és agytörzsében kimutattuk, hogy a neuronok körüli, extracellularis matrixban (ECM) gazdag perineuronalis háló (PNN) az embrionális életben megjelenik, míg az emlősökben csak postnatalisan alakul ki.
Bácskai, Tímea, Deák, Ádám, Felszeghy, Szabolcs, Halasi, Gábor György, Matesz, Klára, Mészár, Zoltán, Módis, László, Rácz, Éva, Székely, György   +8 more
core  

Long‐Term Memory Engrams From Development to Adulthood

Hippocampus, Volume 35, Issue 5, September 2025.
ABSTRACT Memories formed in adulthood can last a lifetime, whereas those formed early in life are rapidly forgotten through a process known as infantile amnesia. In recent years, tremendous progress has been made in understanding the memory engram—the physical trace of a memory in the brain—and how it transforms as memories evolve from recent to remote.
Abigail L. Yu, Laura A. DeNardo
wiley   +1 more source

Developmental disruption of perineuronal nets in the medial prefrontal cortex after maternal immune activation [PDF]

, 2016
© The Author(s) 2016. Maternal infection during pregnancy increases the risk of offspring developing schizophrenia later in life. Similarly, animal models of maternal immune activation (MIA) induce behavioural and anatomical disturbances consistent with ...
A Faissner, A Klausmeyer, AA Curley, AE Takesian, AR Wolff, AR Wolff, AS Brown, AS Brown, BK Bitanihirwe, C Basar-Eroglu, CJ Machado, CL Beasley, CV Vorhees, CY Pietersen, D Bavelier, D Ibi, D Nakayama, D Wang, DA Lewis, DD Dickerson, DD Dickerson, DW Volk, E Domenici, F Passetti, G Brückner, G Brückner, G Buzsáki, G Gonzalez-Burgos, G Gonzalez-Burgos, G Koppe, H Pantazopoulos, H Pantazopoulos, H Pantazopoulos, H Yamamori, J Richetto, J Zahrt, JF Enwright, JG Howland, JJ Tukker, JR Glausier, K Fox, KE Rhodes, KM Spencer, LA Miner, M Sur, N Berardi, N Gogolla, N Mellios, NV Malkova, PE Gottschall, RY Cho, S Berretta, S Canetta, S Devanarayanan, S Giovanoli, S Hockfield, S Sangha, S Smolders, S Wiese, SA Ballendine, SA Mauney,, SJ Fung, SN Cassella, T Hashimoto, T Pizzorusso, T Reinert, U Meyer, U Meyer, U Meyer, VS Sohal, W Härtig, W Härtig, WW Eaton, WY Li, Y Piontkewitz, Y Zhang   +75 more
core   +1 more source

Phagocytosis of aggrecan-positive perineuronal nets surrounding motor neurons by reactive microglia expressing MMP-9 in TDP-43Q331K ALS model mice

Neurobiology of Disease
Perineuronal nets (PNNs) are extracellular matrix structures that surround excitable neurons and their proximal dendrites. PNNs play an important role in neuroprotection against oxidative stress. Oxidative stress within motor neurons can act as a trigger
Sang Won Cheung, Emily F. Willis, David G. Simmons, Mark C. Bellingham, Peter G. Noakes   +4 more
doaj   +1 more source

Alteration of perineuronal nets and parvalbumin interneurons in prefrontal cortex and hippocampus, and correlation with blood corticosterone in activity-based anorexia model mice [PDF]

Anorexia nervosa (AN) is an eating disorder characterized by restricted energy intake, severely underweight status, and frequent hyperactivity. Previous research has shown structural and functional alterations in the medial prefrontal cortex (mPFC) and ...
Kawai, Hiroki, Miyazaki, Haruko, Nguyen, Hoang Duy, Oohashi, Toshitaka, Sakamoto, Shinji, Takaki, Manabu, Wang, Ziyi   +6 more
core   +1 more source