Results 61 to 70 of about 1,449 (148)
Distribution of N-Acetylgalactosamine-Positive Perineuronal Nets in the Macaque Brain: Anatomy and Implications [PDF]
, 2016 Perineuronal nets (PNNs) are extracellular molecules that form around neurons near the end of critical periods during development. They surround neuronal cell bodies and proximal dendrites.
Adam Davis +4 more
core +3 more sources
The critical role of extracellular matrix in Alzheimer's disease
Alzheimer's &Dementia, Volume 21, Issue S1, December 2025.Abstract Background In central nervous system, all components are enveloped by the extracellular matrix (ECM), regulating microenvironmental homeostasis and neuronal development. The condensed cartilage‐like ECM called perineuronal nets (PNNs), mainly surrounding parvalbumin‐expressing (PV+) fast‐firing GABAergic interneurons, are crucial to synaptic ...
Xiaolei Zhu, Zhen Lan, Yun Xu
wiley +1 more source
Frontiers in NeuroscienceMaturation of the forebrain involves transitions from higher to lower levels of synaptic plasticity. The timecourse of these changes likely differs between regions, with the stabilization of some networks scaffolding the development of others.
B. Maximiliano Garduño +9 more
doaj +1 more source
Role of perineuronal nets in Alzheimer's Disease‐associated social memory impairment
Alzheimer's &Dementia, Volume 21, Issue S1, December 2025.Abstract Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting approximately 55 million people worldwide. Key pathological features of AD include the accumulation of beta‐amyloid plaques and hyperphosphorylated tau tangles.
Lata Chaunsali
wiley +1 more source
Extracellular matrix of the central nervous system: from neglect to challenge [PDF]
, 2018 The basic concept, that specialized extracellular matrices rich in hyaluronan, chondroitin sulfate proteoglycans (aggrecan, versican, neurocan, brevican, phosphacan), link proteins and tenascins (Tn-R, Tn-C) can regulate cellular migration and axonal ...
Dours-Zimmermann, María +1 more
core
JOR SPINE, Volume 8, Issue 4, December 2025.Matrix and cell‐associated proteoglycans are important tissue‐stabilizing, weight‐bearing, and tension‐resisting proteins in the intervertebral disc. Their glycosaminoglycan components have growth factor binding and cell‐instructive properties that allow cells to regulate tissue composition and function.
James Melrose
wiley +1 more source
Abstract Perineuronal nets (PNNs) are key regulators of neuronal excitability, yet whether they are altered during neurogenic hypertension is unknown. Here, we mapped the developmental trajectory of PNNs in the paraventricular nucleus of the hypothalamus (PVN), a crucial nucleus involved in blood pressure regulation, and examined their ...
Blanco, Ismary +4 more
openaire +1 more source
Specialized motor-driven dusp1 expression in the song systems of multiple lineages of vocal learning birds. [PDF]
, 2012 Mechanisms for the evolution of convergent behavioral traits are largely unknown. Vocal learning is one such trait that evolved multiple times and is necessary in humans for the acquisition of spoken language.
Horita, H +5 more
core +4 more sources
European Journal of Neuroscience, Volume 62, Issue 10, November 2025.Environmental enrichment (EE) reduces cue‐evoked sucrose seeking and is accompanied by enhanced inhibitory interneuron excitability and suppressed corticothalamic recruitment in the prelimbic cortex. Using brain slice electrophysiology, retrograde tracing and Fos assays, we show that EE increases baseline excitability of interneurons but not pyramidal ...
Kate Z. Peters +4 more
wiley +1 more source
Journal of Neurochemistry, Volume 169, Issue 11, November 2025.In this review, we discuss the development and maturation of inhibitory neurons and astrocytes and how early developmental activity in the brain might promote the interactions between these cell types. Early in development, excitatory neurons are the first to emerge.
Niina Lehti Tauriala, Vered Kellner
wiley +1 more source