Results 81 to 90 of about 1,848 (164)

Neurocan Inhibits Semaphorin 3F Induced Dendritic Spine Remodeling Through NrCAM in Cortical Neurons

Frontiers in Cellular Neuroscience, 2018
Neurocan is a chondroitin sulfate proteoglycan present in perineuronal nets, which are associated with closure of the critical period of synaptic plasticity.
Vishwa Mohan, Elliott V. Wyatt, Ingo Gotthard, Kristen D. Phend, Simone Diestel, Bryce W. Duncan, Richard J. Weinberg, Ashutosh Tripathy, Patricia F. Maness   +8 more
doaj   +1 more source

Screening Biomarkers for Nerve Injury Using Weighted Gene Co‐Expression Network Analysis and Machine Learning

Brain and Behavior, Volume 16, Issue 2, February 2026.
This study identifies Atf3, Bin2, Fcgr2b, and Ucn as key diagnostic genes for nerve injury, linking them to neuroinflammation and immune cell dynamics. Fcgr2b was further shown to functionally promote neurite outgrowth. ABSTRACT Background Nerve injury triggers complex molecular responses involving immune activation and neuronal damage, yet the key ...
Shuming Cao, Chengyue Yu, Nana Wang, Jianhua Xu, Weiguo Xu   +4 more
wiley   +1 more source

Glucagon‐Like Peptide‐1 Targets in the Human Nodose Ganglion

Journal of Comparative Neurology, Volume 534, Issue 2, February 2026.
Our findings demonstrate that the human nodose ganglion expresses Glp1r mRNA and reveal species similarities and differences in Glp1r expression between humans and mice. ABSTRACT Given the rapidly expanding clinical use of glucagon‐like peptide‐1 receptor (GLP1R) agonists—well‐known for their antidiabetic and antiobesity effects—it is increasingly ...
Warda Merchant, Claire Mackaaij, Cindy G. J. Cleypool, Laurent Gautron   +3 more
wiley   +1 more source

Juvenile stress induces behavioral change and affects perineuronal net formation in juvenile mice

BMC Neuroscience, 2018
Background Many neuropsychiatric disorders develop in early life. Although the mechanisms involved have not been elucidated, it is possible that functional abnormalities of parvalbumin-positive interneurons (PV neurons) are present.
Hiroshi Ueno, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yosuke Matsumoto, Motoi Okamoto, Shozo Aoki, Takeshi Ishihara   +8 more
doaj   +1 more source

Effect of Shock-Induced Cavitation Bubble Collapse on the damage in the Simulated Perineuronal Net of the Brain

Scientific Reports, 2017
The purpose of this study is to conduct modeling and simulation to understand the effect of shock-induced mechanical loading, in the form of cavitation bubble collapse, on damage to the brain’s perineuronal nets (PNNs).
Yuan-Ting Wu, Ashfaq Adnan
doaj   +1 more source

Chondroitin Sulfate Expression in Perineuronal Nets After Goldfish Spinal Cord Lesion

Frontiers in Cellular Neuroscience, 2018
Perineuronal nets (PNNs) surrounding neuronal cell bodies regulate neuronal plasticity during development, but their roles in regeneration are unclear. In the PNNs, chondroitin sulfate (CS) is assumed to be involved in inhibiting contact formation. Here,
Akihito Takeda, Masashige Shuto, Kengo Funakoshi   +2 more
doaj   +1 more source

Reorganization of Synaptic Connections and Perineuronal Nets in the Deep Cerebellar Nuclei of Purkinje Cell Degeneration Mutant Mice

Neural Plasticity, 2016
The perineuronal net (PN) is a subtype of extracellular matrix appearing as a net-like structure around distinct neurons throughout the whole CNS. PNs surround the soma, proximal dendrites, and the axonal initial segment embedding synaptic terminals on ...
M. Blosa, C. Bursch, S. Weigel, M. Holzer, C. Jäger, C. Janke, R. T. Matthews, T. Arendt, M. Morawski   +8 more
doaj   +1 more source

Reorganization of Spinal Cord Microarchitecture by Bioluminescent Optogenetic and Rehabilitative Interventions

Cells
Spinal cord injury (SCI) induces persistent locomotor deficits that are closely associated with maladaptive structural plasticity of spinal neuronal circuits.
Tatyana Ageeva, Rezeda Shigapova, Aizilya Bilalova, Elizaveta Plotnikova, Amina Akmanova, Albert Rizvanov, Yana Mukhamedshina   +6 more
doaj   +1 more source

Perineuronal nets in neurodegeneration

Oncotarget, 2016
Lemarchant, Sighild, Wojciechowski, Sara, Koistinaho, Jari   +2 more
openaire   +2 more sources

How the forebrain transitions to adulthood: developmental plasticity markers in a long-lived rodent reveal region diversity and the uniqueness of adolescence

Frontiers in Neuroscience
Maturation of the forebrain involves transitions from higher to lower levels of synaptic plasticity. The timecourse of these changes likely differs between regions, with the stabilization of some networks scaffolding the development of others.
B. Maximiliano Garduño, Patrick Hanni, Chelsea Hays, Patricia Cogram, Patricia Cogram, Nathan Insel, Nathan Insel, Xiangmin Xu, Xiangmin Xu, Xiangmin Xu   +9 more
doaj   +1 more source