Results 91 to 100 of about 2,231 (191)
iScienceSummary: Visual cortical plasticity is high during early life, but gradually decreases with development. This is due to the Otx2-driven maturation of intracortical inhibition that parallels the condensation of extracellular matrix components into ...
Dmytro Shmal +4 more
doaj +1 more source
Reductionism in Engram Neuroscience
European Journal of Neuroscience, Volume 63, Issue 8, April 2026.Reductionist methods inspire several seemingly incompatible explanations and ontologies. But such adversarial approaches can be fruitful for theorising in neuroscience. We argue that reductionist methods are at their most useful when coupled with integrative practices that include multiple heterarchical levels of organisation, various kinds of analysis,
Caitlin Mace +2 more
wiley +1 more source
Perineuronal Nets: Plasticity, Protection, and Therapeutic Potential
Trends in Neurosciences, 2019 The relationship between neurons and perineuronal nets (PNNs) is attracting attention as a central mechanism controlling brain plasticity. In the cortex, PNNs primarily surround inhibitory parvalbumin interneurons, playing roles as both a regulator of synaptic plasticity and a protective barrier. PNNs have a delayed developmental trajectory and are key
Reichelt, Amy C. +3 more
openaire +4 more sources
Ibrain, Volume 12, Issue 1, Page 65-85, Spring 2026.Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley +1 more source
Perineuronal nets in the rhesus monkey and human basal forebrain including basal ganglia
, 2001 Perineuronal nets of extracellular matrix have been shown to characterize the microenvironment of individual neurons and the chemoarchitecture of brain regions such as basal forebrain nuclei, Previous work has also demonstrated that neurons in the human ...
Brauer, K. +7 more
core +1 more source
Neurocan Inhibits Semaphorin 3F Induced Dendritic Spine Remodeling Through NrCAM in Cortical Neurons
Frontiers in Cellular Neuroscience, 2018 Neurocan is a chondroitin sulfate proteoglycan present in perineuronal nets, which are associated with closure of the critical period of synaptic plasticity.
Vishwa Mohan +8 more
doaj +1 more source
, 2000 The present study showed that many neurons in the adult rat brain possessed a perineuronal sulfated proteoglycan surface coat which reacted to cationic iron colloid and aldehyde fuchsin. This surface coat was stained supravitally with Ehrlich's methylene
Nishizaki, Kazunori +6 more
core +1 more source
Image_2_Neonatal Zika virus infection causes transient perineuronal net degradation.TIF
, 2023 Perineuronal nets (PNNs) form a specialized extracellular matrix that predominantly surrounds parvalbumin (PV)-expressing GABAergic inhibitory interneurons and help regulate neuronal activity. Their formation early in the postnatal period is regulated by
Bhanu P. Tewari (16523466) +6 more
core +1 more source
Juvenile stress induces behavioral change and affects perineuronal net formation in juvenile mice
BMC Neuroscience, 2018 Background Many neuropsychiatric disorders develop in early life. Although the mechanisms involved have not been elucidated, it is possible that functional abnormalities of parvalbumin-positive interneurons (PV neurons) are present.
Hiroshi Ueno +8 more
doaj +1 more source
The Role of Perineuronal Nets in Learning and Memory
, 2018 The balance between stability and plasticity in the brain determines our ability to learn. A key molecular regulator of this balance includes perineuronal nets.
Nath, Moushumi
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