Results 51 to 60 of about 1,903 (160)

WONOEP XVII appraisal: The role of the extracellular matrix in epilepsy

Epilepsia, EarlyView.
Abstract The extracellular matrix (ECM) is composed of proteoglycans and glycoproteins that regulate the external environment surrounding neurons, glia, and the vascular system. The ECM is vital for maintaining the structure and function of the brain and also acts as a reservoir for various signaling molecules and neurotransmitters, modulating synaptic
Eleonora Lugara, Erwin A. van Vliet, Alessia Romagnolo, Kevin Staley, Kyle P. Lillis, Chris Dulla, David C. Henshall, Katja Kobow   +7 more
wiley   +1 more source

WFA-labeled perineuronal nets in the macaque claustrum [PDF]

Claustrum, 2018
The claustrum (CLA) has been discussed as central to integrated conscious percepts, although recent evidence has emphasized a role in detecting sensory novelty or in amplifying correlated cortical inputs.We report that many neurons in the macaque CLA are ensheathed in perineuronal nets (PNNs), which contribute to synaptic stability and enhance neuronal
Mihovil Pletikos, Kathleen S. Rockland
openaire   +2 more sources

Developmental patterns of extracellular matrix molecules in the embryonic and postnatal mouse hindbrain

Frontiers in Neuroanatomy
Normal brain development requires continuous communication between developing neurons and their environment filled by a complex network referred to as extracellular matrix (ECM). The ECM is divided into distinct families of molecules including hyaluronic
Ildikó Wéber, Adél Dakos, Zoltán Mészár, Clara Matesz, Clara Matesz, András Birinyi   +5 more
doaj   +1 more source

QUANTITATIVE HISTOCHEMICAL STUDY ON THE POSTNATAL DEVELOPMENT OF PERINEURONAL NETS IN THE RETROSPLENIAL CORTEX OF ALBINO RATS [PDF]

Assiut Veterinary Medical Journal, 2009
 Reticular or lattice-like perineuronal coatings of condensed extracellular matrix (ECM), termed perineuronal nets (PNs), enriched in proteoglycans (PGs) and/or glycoproteins (GPs) were demonstrated to ensheath cell surfaces of certain neuronal circuits ...
R. SAYED
doaj   +1 more source

Heparan sulfate and glycomimetics: Advances in synthesis and biological applications for post‐stroke neurorepair

Neuroprotection, EarlyView.
ECM, extracellular matrix; BDNF, brain‐derived neuroptrophic factor; FGF, fibroblast growth factor; VEGF, vascular endothelial growth factor. Abstract Heparan sulfate, a structurally diverse glycosaminoglycan that is abundant in the central nervous system (CNS), orchestrates essential processes fundamental to neural plasticity, neurorepair, and ...
Mozammel H. Bhuiyan, Madeleine J. Smith, Simon F. R. Hinkley, Andrew N. Clarkson   +3 more
wiley   +1 more source

Perineuronal nets and schizophrenia: The importance of neuronal coatings [PDF]

Neuroscience & Biobehavioral Reviews, 2014
Schizophrenia is a complex brain disorder associated with deficits in synaptic connectivity. The insidious onset of this illness during late adolescence and early adulthood has been reported to be dependent on several key processes of brain development including synaptic refinement, myelination and the physiological maturation of inhibitory neural ...
Bitanihirwe BK, Woo TU
openaire   +3 more sources

Sensory Experience as a Regulator of Structural Plasticity in the Developing Whisker-to-Barrel System

Frontiers in Cellular Neuroscience, 2021
Cellular structures provide the physical foundation for the functionality of the nervous system, and their developmental trajectory can be influenced by the characteristics of the external environment that an organism interacts with.
Chia-Chien Chen, Chia-Chien Chen, Joshua C. Brumberg, Joshua C. Brumberg   +3 more
doaj   +1 more source

Distinctly altered TRPC3 and TRPC6 expression patterns in human Alzheimer's disease cortex and hippocampus

Brain Pathology, EarlyView.
Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen, Zhengjun Wang, Jiaxing Wang, Dehui Kong, Xusheng Wang, Lu Lu, Peter T. Nelson, Fu‐Ming Zhou, Francesca‐Fang Liao   +8 more
wiley   +1 more source

Perineuronal nets in brain physiology and disease

Seminars in Cell & Developmental Biology, 2019
Perineuronal nets (PNNs) in the brain are condensed glycosaminoglycan-rich extracellular matrix structures with heterogeneous composition yet specific organization. They typically assemble around a subset of fast-spiking interneurons that are implicated in learning and memory.
Damien Testa, Alain Prochiantz, Ariel A. Di Nardo   +2 more
openaire   +3 more sources

The Chemorepulsive Protein Semaphorin 3A and Perineuronal Net-Mediated Plasticity

Neural Plasticity, 2016
During postnatal development, closure of critical periods coincides with the appearance of extracellular matrix structures, called perineuronal nets (PNN), around various neuronal populations throughout the brain.
F. de Winter, J. C. F. Kwok, J. W. Fawcett, T. T. Vo, D. Carulli, J. Verhaagen   +5 more
doaj   +1 more source