Results 51 to 60 of about 2,231 (191)

Perineuronal nets stabilize the grid cell network [PDF]

Nature Communications, 2019
Abstract Grid cells are part of a widespread network that supports navigation and spatial memory. Stable grid patterns appear late in development, in concert with extracellular matrix aggregates termed perineuronal nets (PNNs) that condense around inhibitory neurons.
Ane Charlotte Christensen, Kristian Kinden Lensjø, Mikkel Elle Lepperød, Svenn-Arne Dragly, Halvard Sutterud, Jan Sigurd Blackstad, Marianne Fyhn, Torkel Hafting   +7 more
openaire   +6 more sources

11-keto-β-boswellic acid and Z-guggulsterone suppress HMGB1/TLR4 pathway activity and modulate microglial polarization to remodel perineuronal nets after nerve injury

Journal of Advanced Research
Introduction: Remodeling of perineuronal nets is an emerging strategy for treating neuropathic pain (NP) and aligns with the traditional Chinese medicine concept of dispersing blood stasis dispersion and dredging collateral channels.
Yucheng Liao, Le Yang, Yi Ding, Chao Guo, Junping Hu, Xinliang Xu, Hui Zhu, Jianhua Yang, Minggao Zhao   +8 more
doaj   +1 more source

Normal abducens nucleus perineuronal net immunostaining.

, 2015
Detection of perineuronal nets by aggrecan (ACAN) immunolabeling in the abducens nucleus (nVI) appeared similar in control subject and patient specimens.
Wolfgang Härtig (232795), Govind Nair (690278), Scott D. Z. Eggers (764607), Anja K. E. Horn (499553), Sigrun Roeber (46364), Daniel S. Reich (114120), R. John Leigh (283010)   +6 more
core   +1 more source

Perineuronal Nets: Subtle Structures with Large Implications

The Neuroscientist, 2022
Perineuronal nets (PNNs) are specialized structures of the extracellular matrix that surround the soma and proximal dendrites of certain neurons in the central nervous system, particularly parvalbumin-expressing interneurons. Their appearance overlaps the maturation of neuronal circuits and the closure of critical periods in different regions of the ...
Héctor Carceller, Yaiza Gramuntell, Patrycja Klimczak, Juan Nacher   +3 more
openaire   +5 more sources

Maturation of PNN and ErbB4 Signaling in Area CA2 during Adolescence Underlies the Emergence of PV Interneuron Plasticity and Social Memory

Cell Reports, 2019
Summary: Adolescence is a vulnerable period characterized by major cognitive changes. The mechanisms underlying the emergence of new cognitive functions are poorly understood.
Soledad Domínguez, Christophe Clément Rey, Ludivine Therreau, Aurélien Fanton, Dominique Massotte, Laure Verret, Rebecca Ann Piskorowski, Vivien Chevaleyre   +7 more
doaj   +1 more source

Reconsideration of the Semaphorin-3A Binding Motif Found in Chondroitin Sulfate Using Galnac4s-6st-Knockout Mice

Biomolecules, 2020
The chondroitin sulfate (CS)-rich dense extracellular matrix surrounding neuron cell bodies and proximal dendrites in a mesh-like structure is called a perineuronal net (PNN).
Satomi Nadanaka, Shinji Miyata, Bai Yaqiang, Jun-ichi Tamura, Osami Habuchi, Hiroshi Kitagawa   +5 more
doaj   +1 more source

Comparative analysis of the methods for quantitative study of the perineuronal net microstructure

Учёные записки Казанского университета: Серия Естественные науки, 2022
Perineuronal nets (PNN) are a special and highly structured type of the CNS extracellular matrix. In past few years, the important role of PNN in the normal physiology of the CNS and the changes in their expression associated with some pathologies have ...
N.S. Lipachev, A.S. Dvoeglazova, A.A. Sadreeva, A.V. Aganov, M.N. Paveliev   +4 more
doaj   +1 more source

Hyperacute Interleukin‐1β Production and Neutrophil Extracellular Trap Formation in the Cerebral Circulation of Stroke Patients with Large Vessel Occlusion

Annals of Neurology, EarlyView.
Acute ischemic stroke due to large vessel occlusion is associated with rapid intravascular immune activation. Analysis of arterial blood sampled distal to the thrombus during mechanical thrombectomy revealed increased extracellular adenosine triphosphate (ATP) and interleukin‐1β (IL‐1β) levels, evidence of inflammasome priming in monocytes, and ...
Justine Münsterberg, Caspar Brekenfeld, Hanna Englert, Marius Piepke, Regine J. Dress, Martin Oertel, Tina Fischer, Romy Hackbusch, Mingming Zha, Haodi Cai, Christian Casar, Ines S. Schädlich, Leo Winter, Alina Jander, Karoline Degenhardt, Maxim Bester, Fabian Flottmann, Uta Hanning, Brigitte Holst, Anna Worthman, Johanna Hiefner, Berenike Rutz, Eckhard Schlemm, Götz Thomalla, Bettina H. Clausen, Ann M. Stowe, Immo Prinz, Thiruma V. Arumugam, Markus Glatzel, Thomas Renné, Jens Fiehler, Eva Tolosa, Tim Magnus, Mathias Gelderblom   +33 more
wiley   +1 more source

Absent or fragmented omnipause neuron perineuronal net triple immunofluorescence staining.

, 2015
Triple immunofluorescence staining for different components of perineuronal nets, revealed by a confocal laser scanning microscope. In the control case, omnipause neurons (OPN) are ensheathed by prominent perineuronal nets showing the same appearance ...
Wolfgang Härtig (232795), Govind Nair (690278), Scott D. Z. Eggers (764607), Anja K. E. Horn (499553), Sigrun Roeber (46364), Daniel S. Reich (114120), R. John Leigh (283010)   +6 more
core   +1 more source

WFA-labeled perineuronal nets in the macaque claustrum [PDF]

Claustrum, 2018
The claustrum (CLA) has been discussed as central to integrated conscious percepts, although recent evidence has emphasized a role in detecting sensory novelty or in amplifying correlated cortical inputs.We report that many neurons in the macaque CLA are ensheathed in perineuronal nets (PNNs), which contribute to synaptic stability and enhance neuronal
Mihovil Pletikos, Kathleen S. Rockland
openaire   +2 more sources