Results 51 to 60 of about 158 (88)

Chondroitin 6-Sulfation Regulates Perineuronal Net Formation by Controlling the Stability of Aggrecan

Neural Plasticity, 2016
Perineuronal nets (PNNs) are lattice-like extracellular matrix structures composed of chondroitin sulfate proteoglycans (CSPGs). The appearance of PNNs parallels the decline of neural plasticity, and disruption of PNNs reactivates neural plasticity in ...
Shinji Miyata, Hiroshi Kitagawa
doaj   +1 more source

Parvalbumin interneurons in Alzheimer's disease: Physiological insights and pathophysiological mechanisms

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Physiological and Pathological Alterations in PV+ Neurons: Under physiological conditions, PV+ interneurons exhibit fast‐spiking properties and generate gamma oscillations at the cost of high energy consumption. In AD, PV+ neurons display abnormalities in ion channels, dendrites, neurotransmission, energy metabolism, and neural oscillations, ultimately
Mengyan Wu, Xingdong Zeng, Yongle Cai, Haonan Chen, Qianying Li, Hao Yang   +5 more
wiley   +1 more source

Age-related inflammatory changes and perineuronal net dynamics: implications for aging

Journal of Neuroinflammation
Background Healthy aging alone can lead to cognitive decline, decreased brain size, protein aggregation, accumulation of senescent cells and neuroinflammation.
Zachary A. Colon, Shannon C. Chan, Kathleen A. Maguire-Zeiss   +2 more
doaj   +1 more source

Heparan sulfate and glycomimetics: Advances in synthesis and biological applications for post‐stroke neurorepair

Neuroprotection, Volume 4, Issue 3, Page 213-228, September 2026.
ECM, extracellular matrix; BDNF, brain‐derived neuroptrophic factor; FGF, fibroblast growth factor; VEGF, vascular endothelial growth factor. Abstract Heparan sulfate, a structurally diverse glycosaminoglycan that is abundant in the central nervous system (CNS), orchestrates essential processes fundamental to neural plasticity, neurorepair, and ...
Mozammel H. Bhuiyan, Madeleine J. Smith, Simon F. R. Hinkley, Andrew N. Clarkson   +3 more
wiley   +1 more source

Restoring vision in adult amblyopia by enhancing plasticity through deletion of the transcriptional repressor REST

iScience
Summary: Visual cortical plasticity is high during early life, but gradually decreases with development. This is due to the Otx2-driven maturation of intracortical inhibition that parallels the condensation of extracellular matrix components into ...
Dmytro Shmal, Giulia Mantero, Thomas Floss, Fabio Benfenati, José Fernando Maya-Vetencourt   +4 more
doaj   +1 more source

WONOEP XVII appraisal: The role of the extracellular matrix in epilepsy

Epilepsia, Volume 67, Issue 8, Page 3894-3908, August 2026.
Abstract The extracellular matrix (ECM) is composed of proteoglycans and glycoproteins that regulate the external environment surrounding neurons, glia, and the vascular system. The ECM is vital for maintaining the structure and function of the brain and also acts as a reservoir for various signaling molecules and neurotransmitters, modulating synaptic
Eleonora Lugara, Erwin A. van Vliet, Alessia Romagnolo, Kevin Staley, Kyle P. Lillis, Chris Dulla, David C. Henshall, Katja Kobow   +7 more
wiley   +1 more source

Neurocan Inhibits Semaphorin 3F Induced Dendritic Spine Remodeling Through NrCAM in Cortical Neurons

Frontiers in Cellular Neuroscience, 2018
Neurocan is a chondroitin sulfate proteoglycan present in perineuronal nets, which are associated with closure of the critical period of synaptic plasticity.
Vishwa Mohan, Elliott V. Wyatt, Ingo Gotthard, Kristen D. Phend, Simone Diestel, Bryce W. Duncan, Richard J. Weinberg, Ashutosh Tripathy, Patricia F. Maness   +8 more
doaj   +1 more source

Perineuronal Net Alterations Following Early-Life Stress: Are Microglia Pulling Some Strings?

Biomolecules
The extracellular matrix plays a key role in synapse formation and in the modulation of synaptic function in the central nervous system. Recent investigations have revealed that microglia, the resident immune cells of the brain, are involved in ...
Reza Rahimian, Claudia Belliveau, Sophie Simard, Gustavo Turecki, Naguib Mechawar   +4 more
doaj   +1 more source

DNMT1 function in cortical PV interneurons modulates cortical network activity, mood disorder‑related behavior, and perineuronal nets

Communications Biology
Parvalbuminergic (PV) interneurons are central to cortical network stability and psychiatric vulnerability. Here, we identify DNA methyltransferase 1 (DNMT1) as a key epigenetic regulator linking PV interneuron function to glial and extracellular matrix ...
Jenice Linde, Can Bora Yildiz, Katharina Vöhringer, Gerion Nabbefeld, Severin Graff, Daniel Pensold, Julia Reichard, Marie Hermanns, Laura Koch, Magdalena Sophie Müller, Ayushi Tanwar, Christoph Weber-Hamacher, Ivan G. Costa Filho, Thomas Stiehl, Marc Spehr, Björn Kampa, Anja Urbach, Simon Musall, Geraldine Zimmer-Bensch   +18 more
doaj   +1 more source

Effect of Shock-Induced Cavitation Bubble Collapse on the damage in the Simulated Perineuronal Net of the Brain

Scientific Reports, 2017
The purpose of this study is to conduct modeling and simulation to understand the effect of shock-induced mechanical loading, in the form of cavitation bubble collapse, on damage to the brain’s perineuronal nets (PNNs).
Yuan-Ting Wu, Ashfaq Adnan
doaj   +1 more source