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Diverse functions of perineuronal nets
Acta Neurobiologiae Experimentalis, 2009 Perineuronal nets represent well-organised components of the extracellular matrix, which are surrounding cell bodies, dendrites, and axon segments of a particular class of neurones as well as forming lattice-like structures. The role of perineuronal nets is not fully elucidated yet.
Magdalena, Karetko +1 more
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Longitudinal in vivo imaging of perineuronal nets
Neurophotonics, 2023 Perineuronal nets (PNNs) are extracellular matrix structures implicated in learning, memory, information processing, synaptic plasticity, and neuroprotection. However, our understanding of mechanisms governing the evidently important contribution of PNNs to central nervous system function is lacking.
Benbenishty, Amit +8 more
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Neurobiology of Disease, 1999 GABA-interneurons immunoreactive (IR) for the calcium-binding protein parvalbumin are lost during the early stages of Creutzfeldt-Jakob disease (CJD) and diminution in their number may partially account for the neurological disturbances manifested in ...
Pavel V. Belichenko +4 more
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Perineuronal Nets and CNS Plasticity and Repair [PDF]
Neural Plasticity, 2016 The extracellular matrix (ECM) of the nervous system regulates numerous events during development, from neurogenesis and gliogenesis to circuitry formation, as well as in adulthood, affecting damage responses, plasticity, and regeneration. Substantial changes in the quantity and the composition of ECM occur during development.
CARULLI, Daniela +2 more
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Brain Research Bulletin, 2022 Hyaluronan (HA) is a core constituent of perineuronal nets (PNNs) that surround subpopulations of neurones. The PNNs control synaptic stabilization in both the developing and adult central nervous system, and disruption of PNNs has shown to reactivate ...
Jana Dubisova +8 more
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Hypothalamic Perineuronal Nets Are Regulated by Sex and Dietary Interventions
Frontiers in Physiology, 2021 Perineuronal nets (PNNs) are widely present in the hypothalamus, and are thought to provide physical protection and ion buffering for neurons and regulate their synaptic plasticity and intracellular signaling.
Nan Zhang +21 more
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Semaphorins in Adult Nervous System Plasticity and Disease
Frontiers in Synaptic Neuroscience, 2021 Semaphorins, originally discovered as guidance cues for developing axons, are involved in many processes that shape the nervous system during development, from neuronal proliferation and migration to neuritogenesis and synapse formation.
Daniela Carulli +3 more
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The altered expression of perineuronal net elements during neural differentiation
Cellular & Molecular Biology Letters, 2018 Background Perineuronal nets (PNNs), which are localized around neurons during development, are specialized forms of neural extracellular matrix with neuroprotective and plasticity-regulating roles.
Nazli F. Eskici +2 more
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Releasing Addiction Memories Trapped in Perineuronal Nets [PDF]
Trends in Genetics, 2018 Drug addiction can be conceptualized at a basic level as maladaptive learning and memory. Addictive substances elicit changes in brain circuitry involved in reward, cognition, and emotional state, leading to the formation and persistence of strong drug-associated memories that lead to craving and relapse.
Amy W. Lasek, Hu Chen, Wei-Yang Chen
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Proteoglycans in Perineuronal Nets.
ACTA HISTOCHEMICA ET CYTOCHEMICA, 1999 Proteoglycans are one of the major constituents of the extracellular matrix and cell membranes. In the brain, there are two major proteoglycans, chondroitin sulfate proteoglycans and heparan sulfate proteoglycans. In the adult mammalian central nervous system, some species of chondroitin sulfate proteoglycan are localized in the ‘perineuronal net ...
Fumiko Matsui +2 more
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