Results 21 to 30 of about 2,231 (191)

Assessment of Possible Contributions of Hyaluronan and Proteoglycan Binding Link Protein 4 to Differential Perineuronal Net Formation at the Calyx of Held [PDF]

Frontiers in Cell and Developmental Biology, 2021
The calyx of Held is a giant nerve terminal mediating high-frequency excitatory input to principal cells of the medial nucleus of the trapezoid body (MNTB).
Kojiro Nojima, Haruko Miyazaki, Tetsuya Hori, Lydia Vargova, Lydia Vargova, Toshitaka Oohashi   +5 more
doaj   +2 more sources

The Chemorepulsive Protein Semaphorin 3A and Perineuronal Net-Mediated Plasticity

Neural Plasticity, 2016
During postnatal development, closure of critical periods coincides with the appearance of extracellular matrix structures, called perineuronal nets (PNN), around various neuronal populations throughout the brain.
F. de Winter, J. C. F. Kwok, J. W. Fawcett, T. T. Vo, D. Carulli, J. Verhaagen   +5 more
doaj   +2 more sources

Effect of Shock-Induced Cavitation Bubble Collapse on the damage in the Simulated Perineuronal Net of the Brain

Scientific Reports, 2017
The purpose of this study is to conduct modeling and simulation to understand the effect of shock-induced mechanical loading, in the form of cavitation bubble collapse, on damage to the brain’s perineuronal nets (PNNs).
Yuan-Ting Wu, Ashfaq Adnan
doaj   +2 more sources

Swish!-All I Hear is Net-Perineuronal Net That is! [PDF]

Epilepsy Curr
Contribution of Perineuronal Nets to Hyperexcitability in Pilocarpine-Induced Status Epilepticus Woo AM, Fleischel EJ, Patel DC, Sontheimer H.
Stafstrom CE.
europepmc   +4 more sources

Postnatal development of the microstructure of cortical GABAergic synapses and perineuronal nets requires sensory input [PDF]

, 2022
The brain synaptic circuitry is formed as a result of pre-defined genetic programs and sensory experience during postnatal development. Perineuronal nets ensheath synaptic boutons and control several crucial features of the synapse physiology.
Osin, Yuri, Kochneva, Anastasia, Kiyasov, Andrei, Shaikhutdinov, Nurislam, Paveliev, Mikhail, Titova, Angelina, Arnst, Nikita, Melnikova, Anastasia, Dvoeglazova, Anastasia, Mavlikeev, Mikhail, Lipachev, Nikita, Aganov, Albert, Fedosimova, Svetlana   +12 more
core   +3 more sources

Circadian Rhythms of Perineuronal Net Composition. [PDF]

eNeuro, 2020
Abstract Perineuronal nets (PNNs) are extracellular matrix (ECM) structures that envelop neurons and regulate synaptic functions. Long thought to be stable structures, PNNs have been recently shown to respond dynamically during learning, potentially regulating the formation of new synapses. We postulated that PNNs
Pantazopoulos H, Pantazopoulos H, Gisabella B, Rexrode L, Benefield D, Yildiz E, Seltzer P, Valeri J, Chelini G, Reich A, Ardelt M, Berretta S.   +11 more
europepmc   +5 more sources

The extracellular matrix and perineuronal nets in memory

Molecular Psychiatry, 2022
AbstractAll components of the CNS are surrounded by a diffuse extracellular matrix (ECM) containing chondroitin sulphate proteoglycans (CSPGs), heparan sulphate proteoglycans (HSPGs), hyaluronan, various glycoproteins including tenascins and thrombospondin, and many other molecules that are secreted into the ECM and bind to ECM components. In addition,
Fawcett, James W, Fyhn, Marianne, Jendelova, Pavla, Kwok, Jessica CF, Ruzicka, Jiri, Sorg, Barbara A   +5 more
openaire   +7 more sources

Beta3Gn-T7 Is a Keratan Sulfate β1,3 N-Acetylglucosaminyltransferase in the Adult Brain

Frontiers in Neuroanatomy, 2022
Keratan sulfate (KS) glycan is covalently attached to a core protein of proteoglycans. KS is abundant in neuropils and presents densely in close proximity to the perineuronal region of the perineuronal net-positive neurons in the adult brain under ...
Yoshiko Takeda-Uchimura, Kazuchika Nishitsuji, Midori Ikezaki, Tomoya O. Akama, Yoshito Ihara, Fabrice Allain, Kenji Uchimura   +6 more
doaj   +1 more source

Shock-Induced Damage Mechanism of Perineuronal Nets [PDF]

Biomolecules, 2021
The perineuronal net (PNN) region of the brain’s extracellular matrix (ECM) surrounds the neural networks within the brain tissue. The PNN is a protective net-like structure regulating neuronal activity such as neurotransmission, charge balance, and action potential generation.
Khandakar Abu Hasan Al Mahmud, Fuad Hasan, Md Ishak Khan, Ashfaq Adnan   +3 more
openaire   +4 more sources

Parvalbumin interneuron alterations in stress-related mood disorders: A systematic review

Neurobiology of Stress, 2021
Stress-related psychiatric disorders including depression involve complex cellular and molecular changes in the brain, and GABAergic signaling dysfunction is increasingly implicated in the etiology of mood disorders.
George Perlman, Arnaud Tanti, Naguib Mechawar   +2 more
doaj   +1 more source