Results 21 to 30 of about 1,848 (164)
The extracellular matrix and perineuronal nets in memory
Molecular Psychiatry, 2022 AbstractAll components of the CNS are surrounded by a diffuse extracellular matrix (ECM) containing chondroitin sulphate proteoglycans (CSPGs), heparan sulphate proteoglycans (HSPGs), hyaluronan, various glycoproteins including tenascins and thrombospondin, and many other molecules that are secreted into the ECM and bind to ECM components. In addition,
Fawcett, James W +5 more
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Beta3Gn-T7 Is a Keratan Sulfate β1,3 N-Acetylglucosaminyltransferase in the Adult Brain
Frontiers in Neuroanatomy, 2022 Keratan sulfate (KS) glycan is covalently attached to a core protein of proteoglycans. KS is abundant in neuropils and presents densely in close proximity to the perineuronal region of the perineuronal net-positive neurons in the adult brain under ...
Yoshiko Takeda-Uchimura +6 more
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Parvalbumin interneuron alterations in stress-related mood disorders: A systematic review
Neurobiology of Stress, 2021 Stress-related psychiatric disorders including depression involve complex cellular and molecular changes in the brain, and GABAergic signaling dysfunction is increasingly implicated in the etiology of mood disorders.
George Perlman +2 more
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Experience-dependent plasticity and modulation of growth regulatory molecules at central synapses. [PDF]
PLoS ONE, 2011 Structural remodeling or repair of neural circuits depends on the balance between intrinsic neuronal properties and regulatory cues present in the surrounding microenvironment.
Simona Foscarin +7 more
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Perineuronal Nets and Their Role in Synaptic Homeostasis [PDF]
International Journal of Molecular Sciences, 2019 Extracellular matrix (ECM) molecules that are released by neurons and glial cells form perineuronal nets (PNNs) and modulate many neuronal and glial functions. PNNs, whose structure is still not known in detail, surround cell bodies and dendrites, which leaves free space for synapses to come into contact.
Mateusz Bosiacki +6 more
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Scientific Reports, 2022 Postnatal hippocampal neurogenesis has been demonstrated to affect learning and memory in numerous ways. Several studies have now demonstrated that increased neurogenesis can induce forgetting of memories acquired prior to the manipulation of ...
Alexandria Evans +4 more
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Frontiers in Neuroanatomy, 2019 Environmental enrichment can dramatically affect both the development and function of neural circuits. This is accomplished, at least in part, by the regulation of inhibitory cellular networks and related extracellular matrix glycoprotein structures ...
Angela May O’Connor +5 more
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Biomolecules, 2021 Because of their abilities to catalyze generation of toxic free radical species, free concentrations of the redox reactive metals iron and copper are highly regulated.
Jessica A. Burket +2 more
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Proteoglycan Sulphation in the Function of the Mature Central Nervous System
Frontiers in Integrative Neuroscience, 2022 Chondroitin sulphate and heparan sulphate proteoglycans (CSPGS and HSPGs) are found throughout the central nervous system (CNS). CSPGs are ubiquitous in the diffuse extracellular matrix (ECM) between cells and are a major component of perineuronal nets ...
James W. Fawcett +3 more
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Perineuronal nets: Cruise from a honeycomb to the safety nets
Brain Research Bulletin, 2022 The extracellular matrix (ECM) is a significant component of the brain, constituting up to 20 % of the brain volume and perform multifarious functions during development, maturation and regeneration of the central nervous system (CNS). ECM molecules assemble systematically to form a relatively rigid and unique lattice-like structure, known as ...
Urmilla John, Nisha Patro, Ishan Patro
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