Results 11 to 20 of about 2,231 (191)

Parvalbumin interneuron-derived tissue-type plasminogen activator shapes perineuronal net structure [PDF]

BMC Biology, 2022
Background Perineuronal nets (PNNs) are specialized extracellular matrix structures mainly found around fast-spiking parvalbumin (FS-PV) interneurons. In the adult, their degradation alters FS-PV-driven functions, such as brain plasticity and memory, and
Matthieu Lépine, Sara Douceau, Gabrielle Devienne, Paul Prunotto, Sophie Lenoir, Caroline Regnauld, Elsa Pouettre, Juliette Piquet, Laurent Lebouvier, Yannick Hommet, Eric Maubert, Véronique Agin, Bertrand Lambolez, Bruno Cauli, Carine Ali, Denis Vivien   +15 more
doaj   +2 more sources

Age-related inflammatory changes and perineuronal net dynamics: implications for aging [PDF]

Journal of Neuroinflammation
Background Healthy aging alone can lead to cognitive decline, decreased brain size, protein aggregation, accumulation of senescent cells and neuroinflammation.
Zachary A. Colon, Shannon C. Chan, Kathleen A. Maguire-Zeiss   +2 more
doaj   +2 more sources

Region-Specific Alterations of Perineuronal Net Expression in Postmortem Autism Brain Tissue [PDF]

Frontiers in Molecular Neuroscience, 2022
Genetic variance in autism spectrum disorder (ASD) is often associated with mechanisms that broadly fall into the category of neuroplasticity. Parvalbumin positive neurons and their surrounding perineuronal nets (PNNs) are important factors in critical ...
Cheryl Brandenburg, Cheryl Brandenburg, Gene J. Blatt   +2 more
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The Role of Cerebellar Intrinsic Neuronal Excitability, Synaptic Plasticity, and Perineuronal Nets in Eyeblink Conditioning

Biology
Evidence is strong that, in addition to fine motor control, there is an important role for the cerebellum in cognition and emotion. The deep nuclei of the mammalian cerebellum also contain the highest density of perineural nets—mesh-like structures that ...
Bernard G. Schreurs, Deidre E. O’Dell, Desheng Wang   +2 more
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Electroacupuncture facilitates remote fear memory erasure via promoting perineuronal net degradation [PDF]

Translational Psychiatry
Post-retrieval extinction has been effective in erasing recent pathological memories but has been shown failed in erasing remote memories. Pathological memories are often formed over the long term, therefore how to erase the remote pathological memory ...
Shuai-Wen Teng, Wen-Bo Guo, Bing-Feng Song, Yun-Zhang He, Ke-Yan Wang, Shi-Bin Gao, Wei Li, Zhe-Yu Chen   +7 more
doaj   +2 more sources

Perineuronal Net Alterations Following Early-Life Stress: Are Microglia Pulling Some Strings? [PDF]

Biomolecules
The extracellular matrix plays a key role in synapse formation and in the modulation of synaptic function in the central nervous system. Recent investigations have revealed that microglia, the resident immune cells of the brain, are involved in ...
Reza Rahimian, Claudia Belliveau, Sophie Simard, Gustavo Turecki, Naguib Mechawar   +4 more
doaj   +2 more sources

Perineuronal Nets and Their Role in Synaptic Homeostasis [PDF]

International Journal of Molecular Sciences, 2019
Extracellular matrix (ECM) molecules that are released by neurons and glial cells form perineuronal nets (PNNs) and modulate many neuronal and glial functions.
Anna Lubkowska, Magdalena Gąssowska-Dobrowolska, Izabela Gutowska, Dariusz Jeżewski, Marta Fabiańska, Klaudyna Kojder, Mateusz Bosiacki   +6 more
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The altered expression of perineuronal net elements during neural differentiation

Cellular & Molecular Biology Letters, 2018
Background Perineuronal nets (PNNs), which are localized around neurons during development, are specialized forms of neural extracellular matrix with neuroprotective and plasticity-regulating roles.
Nazli F. Eskici, Sevim Erdem-Ozdamar, Didem Dayangac-Erden   +2 more
doaj   +2 more sources

Assessing translational applicability of perineuronal net dysfunction in Alzheimer’s disease across species [PDF]

Frontiers in Neuroscience
In the context of aging and age-associated neurodegenerative disorders, the brain’s extracellular matrix (ECM) serves as a critical regulator for neuronal health and cognitive function.
Aarun S. Hendrickson, Aarun S. Hendrickson, Kendra L. Francis, Kendra L. Francis, Asmit Kumar, Asmit Kumar, Jaden P. Le, Jaden P. Le, Jarrad M. Scarlett, Jarrad M. Scarlett, C. Dirk Keene, David A. Tovar, Kimberly M. Alonge, Kimberly M. Alonge   +13 more
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Hypothalamic Perineuronal Nets Are Regulated by Sex and Dietary Interventions [PDF]

Frontiers in Physiology, 2021
Perineuronal nets (PNNs) are widely present in the hypothalamus, and are thought to provide physical protection and ion buffering for neurons and regulate their synaptic plasticity and intracellular signaling.
Nan Zhang, Nan Zhang, Nan Zhang, Zili Yan, Hailan Liu, Meng Yu, Yang He, Hesong Liu, Chen Liang, Longlong Tu, Lina Wang, Na Yin, Junying Han, Nikolas Scarcelli, Yongjie Yang, Chunmei Wang, Tianshu Zeng, Tianshu Zeng, Lu-Lu Chen, Lu-Lu Chen, Yong Xu, Yong Xu   +21 more
doaj   +4 more sources