Perineuronal Net Dynamics in the Pathophysiology of Epilepsy [PDF]
Epilepsy Currents, 2021 Perineuronal nets (PNNs) are condensed extracellular matrix (ECM) assemblies of polyanionic chondroitin sulfate proteoglycans, hyaluronan, and tenascins that primarily wrap around GABAergic parvalbumin (PV) interneurons. During development, PNN formation terminates the critical period of neuroplasticity, a process that can be reversed by experimental ...
Bhanu P Tewari +2 more
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Caught in the Net: Perineuronal Nets and Addiction [PDF]
Neural Plasticity, 2016 Exposure to drugs of abuse induces plasticity in the brain and creates persistent drug-related memories. These changes in plasticity and persistent drug memories are believed to produce aberrant motivation and reinforcement contributing to addiction ...
Megan Slaker +2 more
doaj +4 more sources
Electroacupuncture facilitates remote fear memory erasure via promoting perineuronal net degradation [PDF]
Translational PsychiatryPost-retrieval extinction has been effective in erasing recent pathological memories but has been shown failed in erasing remote memories. Pathological memories are often formed over the long term, therefore how to erase the remote pathological memory ...
Shuai-Wen Teng +7 more
doaj +2 more sources
Perineuronal Net Alterations Following Early-Life Stress: Are Microglia Pulling Some Strings? [PDF]
BiomoleculesThe extracellular matrix plays a key role in synapse formation and in the modulation of synaptic function in the central nervous system. Recent investigations have revealed that microglia, the resident immune cells of the brain, are involved in ...
Reza Rahimian +4 more
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Minimally invasive protocols and quantification for microglia-mediated perineuronal net disassembly in mouse brain [PDF]
STAR Protocols, 2021 Summary: Enzymatic digestion of the extracellular matrix with chondroitinase-ABC reinstates juvenile-like plasticity in the adult cortex as it also disassembles the perineuronal nets (PNNs).
Alessandro Venturino, Sandra Siegert
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Assessing translational applicability of perineuronal net dysfunction in Alzheimer’s disease across species [PDF]
Frontiers in NeuroscienceIn the context of aging and age-associated neurodegenerative disorders, the brain’s extracellular matrix (ECM) serves as a critical regulator for neuronal health and cognitive function.
Aarun S. Hendrickson +13 more
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Altered lipid peroxidation, perineuronal net and oligodendrocyte markers in the frontal cortex of a dual-hit neurodevelopmental model support its relevance to schizophrenia [PDF]
Frontiers in Cellular NeuroscienceIntroductionThe pathogenesis of schizophrenia begins in early neurodevelopment and leads to an array of frontal cortical deficits. They include redox dysregulation, white matter perturbation, loss of perineuronal nets (PNNs) and reduced synaptic density.
Victoria Esuaikoh +8 more
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Hypothalamic Perineuronal Nets Are Regulated by Sex and Dietary Interventions [PDF]
Frontiers in Physiology, 2021 Perineuronal nets (PNNs) are widely present in the hypothalamus, and are thought to provide physical protection and ion buffering for neurons and regulate their synaptic plasticity and intracellular signaling.
Nan Zhang +21 more
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Swish!-All I Hear is Net-Perineuronal Net That is! [PDF]
Epilepsy CurrContribution of Perineuronal Nets to Hyperexcitability in Pilocarpine-Induced Status Epilepticus Woo AM, Fleischel EJ, Patel DC, Sontheimer H.
Stafstrom CE.
europepmc +4 more sources
A glial perspective on the extracellular matrix and perineuronal net remodeling in the central nervous system [PDF]
Frontiers in Cellular Neuroscience, 2022 Bhanu P Tewari +2 more
exaly +2 more sources