Results 11 to 20 of about 158 (88)
Scientific Reports, 2022 Postnatal hippocampal neurogenesis has been demonstrated to affect learning and memory in numerous ways. Several studies have now demonstrated that increased neurogenesis can induce forgetting of memories acquired prior to the manipulation of ...
Alexandria Evans +4 more
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Frontiers in Neuroanatomy, 2019 Environmental enrichment can dramatically affect both the development and function of neural circuits. This is accomplished, at least in part, by the regulation of inhibitory cellular networks and related extracellular matrix glycoprotein structures ...
Angela May O’Connor +5 more
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Biomolecules, 2021 Because of their abilities to catalyze generation of toxic free radical species, free concentrations of the redox reactive metals iron and copper are highly regulated.
Jessica A. Burket +2 more
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Proteoglycan Sulphation in the Function of the Mature Central Nervous System
Frontiers in Integrative Neuroscience, 2022 Chondroitin sulphate and heparan sulphate proteoglycans (CSPGS and HSPGs) are found throughout the central nervous system (CNS). CSPGs are ubiquitous in the diffuse extracellular matrix (ECM) between cells and are a major component of perineuronal nets ...
James W. Fawcett +3 more
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Region-Specific Alterations of Perineuronal Net Expression in Postmortem Autism Brain Tissue
Frontiers in Molecular Neuroscience, 2022 Genetic variance in autism spectrum disorder (ASD) is often associated with mechanisms that broadly fall into the category of neuroplasticity. Parvalbumin positive neurons and their surrounding perineuronal nets (PNNs) are important factors in critical ...
Cheryl Brandenburg +2 more
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Neurobiology of Disease, 1999 GABA-interneurons immunoreactive (IR) for the calcium-binding protein parvalbumin are lost during the early stages of Creutzfeldt-Jakob disease (CJD) and diminution in their number may partially account for the neurological disturbances manifested in ...
Pavel V. Belichenko +4 more
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Brain Research Bulletin, 2022 Hyaluronan (HA) is a core constituent of perineuronal nets (PNNs) that surround subpopulations of neurones. The PNNs control synaptic stabilization in both the developing and adult central nervous system, and disruption of PNNs has shown to reactivate ...
Jana Dubisova +8 more
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Caught in the Net: Perineuronal Nets and Addiction
Neural Plasticity, 2016 Exposure to drugs of abuse induces plasticity in the brain and creates persistent drug-related memories. These changes in plasticity and persistent drug memories are believed to produce aberrant motivation and reinforcement contributing to addiction ...
Megan Slaker +2 more
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The altered expression of perineuronal net elements during neural differentiation
Cellular & Molecular Biology Letters, 2018 Background Perineuronal nets (PNNs), which are localized around neurons during development, are specialized forms of neural extracellular matrix with neuroprotective and plasticity-regulating roles.
Nazli F. Eskici +2 more
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STAR Protocols, 2021 Summary: Enzymatic digestion of the extracellular matrix with chondroitinase-ABC reinstates juvenile-like plasticity in the adult cortex as it also disassembles the perineuronal nets (PNNs).
Alessandro Venturino, Sandra Siegert
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