Perineuronal Net Dynamics in the Pathophysiology of Epilepsy [PDF]
Epilepsy Currents, 2021 Perineuronal nets (PNNs) are condensed extracellular matrix (ECM) assemblies of polyanionic chondroitin sulfate proteoglycans, hyaluronan, and tenascins that primarily wrap around GABAergic parvalbumin (PV) interneurons. During development, PNN formation terminates the critical period of neuroplasticity, a process that can be reversed by experimental ...
Lata Chaunsali +2 more
exaly +6 more sources
The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders [PDF]
Frontiers in Molecular Neuroscience, 2018 Perineuronal nets (PNN) are extracellular matrix (ECM) assemblies that preferentially ensheath parvalbumin (PV) expressing interneurons. Converging evidence indicates that PV cells and PNN are impaired in a variety of neurological disorders.
Teresa H. Wen +6 more
doaj +5 more sources
Caught in the Net: Perineuronal Nets and Addiction [PDF]
Neural Plasticity, 2016 Exposure to drugs of abuse induces plasticity in the brain and creates persistent drug-related memories. These changes in plasticity and persistent drug memories are believed to produce aberrant motivation and reinforcement contributing to addiction ...
Megan Slaker +2 more
doaj +4 more sources
Perineuronal Net Alterations Following Early-Life Stress: Are Microglia Pulling Some Strings? [PDF]
BiomoleculesThe extracellular matrix plays a key role in synapse formation and in the modulation of synaptic function in the central nervous system. Recent investigations have revealed that microglia, the resident immune cells of the brain, are involved in ...
Reza Rahimian +4 more
doaj +2 more sources
Minimally invasive protocols and quantification for microglia-mediated perineuronal net disassembly in mouse brain [PDF]
STAR Protocols, 2021 Summary: Enzymatic digestion of the extracellular matrix with chondroitinase-ABC reinstates juvenile-like plasticity in the adult cortex as it also disassembles the perineuronal nets (PNNs).
Alessandro Venturino, Sandra Siegert
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Assessing translational applicability of perineuronal net dysfunction in Alzheimer’s disease across species [PDF]
Frontiers in NeuroscienceIn the context of aging and age-associated neurodegenerative disorders, the brain’s extracellular matrix (ECM) serves as a critical regulator for neuronal health and cognitive function.
Aarun S. Hendrickson +13 more
doaj +2 more sources
Shock-Induced Damage Mechanism of Perineuronal Nets [PDF]
Biomolecules, 2021 The perineuronal net (PNN) region of the brain’s extracellular matrix (ECM) surrounds the neural networks within the brain tissue. The PNN is a protective net-like structure regulating neuronal activity such as neurotransmission, charge balance, and ...
Khandakar Abu Hasan Al Mahmud +3 more
doaj +4 more sources
Assessment of Possible Contributions of Hyaluronan and Proteoglycan Binding Link Protein 4 to Differential Perineuronal Net Formation at the Calyx of Held [PDF]
Frontiers in Cell and Developmental Biology, 2021 The calyx of Held is a giant nerve terminal mediating high-frequency excitatory input to principal cells of the medial nucleus of the trapezoid body (MNTB).
Kojiro Nojima +5 more
doaj +2 more sources
Swish!-All I Hear is Net-Perineuronal Net That is! [PDF]
Epilepsy CurrContribution of Perineuronal Nets to Hyperexcitability in Pilocarpine-Induced Status Epilepticus Woo AM, Fleischel EJ, Patel DC, Sontheimer H.
Stafstrom CE.
europepmc +4 more sources
Circadian Rhythms of Perineuronal Net Composition. [PDF]
eNeuro, 2020 Abstract Perineuronal nets (PNNs) are extracellular matrix (ECM) structures that envelop neurons and regulate synaptic functions. Long thought to be stable structures, PNNs have been recently shown to respond dynamically during learning, potentially regulating the formation of new synapses. We postulated that PNNs
Pantazopoulos H +11 more
europepmc +5 more sources