Results 121 to 130 of about 356,744 (339)
Casein kinase 1 proteomics reveal prohibitin 2 function in molecular clock.
PLoS ONE, 2012 Throughout the day, clock proteins synchronize changes in animal physiology (e.g., wakefulness and appetite) with external cues (e.g., daylight and food).
Lorna S Kategaya +5 more
doaj +1 more source
Biological Circuits: Analysis of a Biological Oscillator [PDF]
arXiv, 2012 The simple circadian oscillator found in cyanobacteria can be reconstituted in vitro using three proteins-KaiA, KaiB and KaiC. The total phosphorylation level of KaiC oscillates with a circadian period. Recent experiments elucidated the structure and function of the cyanobacterial circadian oscillator, which is driven by sunlight intensity variation ...
arxiv
British Journal of Clinical Pharmacology, EarlyView.Aim PREDICT‐5FU aimed to document 5‐fluorouracil (5FU) exposure in a cancer population and to evaluate the feasibility of 5FU and capecitabine therapeutic drug monitoring (TDM) in patients receiving standard doses and schedules. Methods Multicentre, prospective, observational single‐arm study.
Sarah Glewis +12 more
wiley +1 more source
Entrainment of a van der Pol-type circadian pacemaker to daylight cycle [PDF]
Brazilian Journal of Physics 2021, 2022 A van der Pol self sustained oscillator with higher order nonlinearity exhibits a rich dynamics, with multiple periodic attractors, and still the model allows analytical approximations. Some of these properties can be conveniently exploited in the framework of circadian oscillations.
arxiv
Damped circadian oscillation in the absence of KaiA in Synechococcus
Nature Communications, 2020 Proteins KaiA, KaiB and KaiC constitute a biochemical circadian oscillator in the cyanobacterium Synechococcus elongatus. It has been reported kaiA inactivation completely abolishes circadian oscillations.
Naohiro Kawamoto +3 more
semanticscholar +1 more source
Medications, epilepsy and climate change: Added layers of complexity
British Journal of Clinical Pharmacology, EarlyView.Climate change—the global crisis with pervasive health impacts—has adverse consequences for people with epilepsy (PWE) who have low quality of life due to poor seizure control, socioeconomic disadvantages and comorbidities. This review focuses on the potential effects of climate change on the pharmacological characteristics of antiseizure medications ...
Medine I. Gulcebi +2 more
wiley +1 more source
Biomedical Journal, 2018 Circadian clocks evolved to allow plants and animals to adapt their behaviors to the 24-hr change in the external environment due to the Earth's rotation.
Rong-Chi Huang
doaj
To Ub or not to Ub: Regulation of circadian clocks by ubiquitination and deubiquitination
Journal of Neurochemistry, 2020 Circadian clocks are internal timing systems that enable organisms to adjust their behavioral and physiological rhythms to the daily changes of their environment.
S. Srikanta, N. Cermakian
semanticscholar +1 more source
Dynamic Compression Improves Chondrogenesis in the Tissue Engineered Model of Cartilage
Biotechnology and Bioengineering, EarlyView.ABSTRACT Hyaline cartilage is a dense avascular tissue with low regenerative potential, present at the ends of the diarthrodial joints and in the cartilage growth plate. Skeletal diseases often result from extracellular changes in this tissue; however, studies of these are hindered by the tissue complexity, the difficulty in obtaining human material ...
Marc V. Farcasanu +8 more
wiley +1 more source
When the clock strikes: Modeling the relation between circadian rhythms and cardiac arrhythmias [PDF]
arXiv, 2016 It has recently been observed that the occurrence of sudden cardiac death has a close statistical relationship with the time of day, viz., ventricular fibrillation is most likely to occur between 12 am-6 am, with 6 pm-12 am being the next most likely period.
arxiv