Results 111 to 120 of about 43,915 (298)

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Thinking Dynamically About Biological Mechanisms: Networks of Coupled Oscillators [PDF]

, 2012
Explaining the complex dynamics exhibited in many biological mechanisms requires extending the recent philosophical treatment of mechanisms that emphasizes sequences of operations.
Bechtel, William, Abrahamsen, Adele
core  

Biomaterials for modulating cellular responses of endogenous tendon stem/progenitor cells: A promising avenue for tendon regeneration

BMEMat, EarlyView.
This review comprehensively summarizes emerging biomaterial‐based strategies and underlying mechanisms for modulating endogenous tendon stem/progenitor cells (TSPCs). It offers the most recent insights into TSPC physiology and potential applications of tissue engineering and regenerative medicine in tendons.
Zeyu Zhu, Renwang Sheng, Mumin Cao, Ludvig J. Backman, Yucheng Gao, Hao Wang, Cheng Zhang, Jialin Chen, Wei Zhang, Yunfeng Rui   +9 more
wiley   +1 more source

The Role of TASK-3 Two-Pore Domain Potassium Channels in the Entrainment of Mammalian Circadian Rhythms [PDF]

, 2014
In mammals light is the principal timing cue for alignment of physiology to the external environment. Illumination from the unrelenting 24-hour day-night cycle enters the biological system and is communicated to the master pacemaker, the suprachiasmatic
Atkinson, Lynsey A
core  

Quantitative analysis of regulatory flexibility under changing environmental conditions [PDF]

, 2010
The circadian clock controls 24-h rhythms in many biological processes, allowing appropriate timing of biological rhythms relative to dawn and dusk. Known clock circuits include multiple, interlocked feedback loops.
Andrew J Millar, Paul E Brown, David A Rand, Kirsten Knox, Knox, Kirsten, Thomson, Adrian W, Akman, Ozgur E, Lumsden, Peter J, Millar, A. J., Ozgur E Akman, Edwards, Kieron D, Brown, Paul E., Rand, D. A., Alexandra Pokhilko, Edwards, Kieron D., Thomson, Adrian W., Rand, David A, Lumsden, P. J., Nagy, Ferenc, Laszlo Kozma‐Bognar, Ra Pokhilko, Adrian W Thomson, Peter J Lumsden, Akman, Ozgur E., Kozma-Bognar, Laszlo, Kieron D Edwards, Ferenc Nagy, Lumsden, Peter J., Pokhilko, Alexandra, Brown, Paul E, Rand, David A., Millar, Andrew J; id_orcid, David A R, Millar, Andrew J., Laszlo Kozma-bognar   +34 more
core   +1 more source

Loss, persistence and reversal of phenotypic traits

Biological Reviews, EarlyView.
ABSTRACT The irreversibility of complex trait loss has long been a tenet of evolutionary biology. However, this idea is increasingly at odds with the numerous documented exceptions across the Tree of Life. We synthesise this growing body of evidence across a diverse array of taxa and traits, exploring the evolutionary conditions that enable ...
Giobbe Forni, Giuseppe Fusco, Filippo Nicolini, Heather Bruce, Andrea Luchetti   +4 more
wiley   +1 more source

Effects of Trimethoprim on Three Previously Proposed Putative Biomarkers for OCT2/MATE‐Mediated Renal Drug‐Drug Interactions in Healthy Volunteers

Clinical Pharmacology &Therapeutics, EarlyView.
Regulatory agencies request the assessment of the potential of new drugs to cause transporter‐mediated drug‐drug interactions (DDI). This assessment can be improved by integrating endogenous biomarkers during drug development. Regarding the renal excretion of drugs such as metformin, the organic cation transporter (OCT) 2 and multidrug and toxin ...
Jana Picurová, Fabian Müller, Daniel Auge, Jörg König, Martin F. Fromm, Arne Gessner   +5 more
wiley   +1 more source

Structural investigation of the Arabidopsis thaliana circadian clock [PDF]

Plants, like most organisms, have developed elaborate mechanisms for anticipating periodic environmental changes. The circadian clock allows an organism to adapt its metabolic, developmental and physiological processes to coincide with favourable ...
Durrant, Oliver
core  

Artificial intelligence in preclinical epilepsy research: Current state, potential, and challenges

Epilepsia Open, EarlyView.
Abstract Preclinical translational epilepsy research uses animal models to better understand the mechanisms underlying epilepsy and its comorbidities, as well as to analyze and develop potential treatments that may mitigate this neurological disorder and its associated conditions. Artificial intelligence (AI) has emerged as a transformative tool across
Jesús Servando Medel‐Matus, Cesar Santana‐Gomez, Ruby G. Escalante, Dominique Duncan, Pedro F. Viana, Giulia Sofia Cereda, Naoto Kuroda, Aristea S. Galanopoulou   +7 more
wiley   +1 more source

Clock gene homologs lin-42 and kin-20 regulate circadian rhythms in C. elegans

Scientific Reports
Circadian rhythms are endogenous oscillations in nearly all organisms, from prokaryotes to humans, allowing them to adapt to cyclical environments for close to 24 h. Circadian rhythms are regulated by a central clock, based on a transcription-translation
Melisa L. Lamberti, Rebecca K. Spangler, Victoria Cerdeira, Myriam Ares, Lise Rivollet, Guinevere E. Ashley, Andrea Ramos Coronado, Sarvind Tripathi, Ignacio Spiousas, Jordan D. Ward, Carrie L. Partch, Claire Y. Bénard, M. Eugenia Goya, Diego A. Golombek   +13 more
doaj   +1 more source