Results 91 to 100 of about 43,915 (298)

Glial Cells in the Genesis and Regulation of Circadian Rhythms

Frontiers in Physiology, 2018
Circadian rhythms are biological oscillations with a period of ~24 h. These rhythms are orchestrated by a circadian timekeeper in the suprachiasmatic nucleus of the hypothalamus, the circadian “master clock,” which exactly adjusts clock outputs to solar ...
Donají Chi-Castañeda, Donají Chi-Castañeda, Arturo Ortega   +2 more
doaj   +1 more source

A Machine Vision‐Guided Microphysiological Platform With Automated Microfluidics Enables Longitudinal Biomarker Monitoring and Emulation of Translationally Relevant Exposure Scenarios

Advanced Science, EarlyView.
A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen, Yi Zhong, Laura Dangel, Sonia Youhanna, Reza Zandi Shafagh, Jinhye Ryu, Domnica‐Gabriela Gurau, Mathias Haag, Thomas E. Mürdter, Yingxin Liang, Iro Beligiani, Nicole Ziegler, Sabine Willems, Nayere Taebnia, Wouter van der Wijngaart, Volker M. Lauschke   +15 more
wiley   +1 more source

Understanding Biological Mechanisms: Using Illustrations from Circadian Rhythm Research [PDF]

, 2012
In many fields of biology, researchers explain a phenomenon by characterizing the responsible mechanism. This requires identifying the candidate mechanism, decomposing it into its parts and operations, recomposing it so as to understand how it is ...
Bechtel, William
core  

Whole‐Genome Sequencing Pilot of the Central Asian Genomic Diversity Project Reveals Distinct Histories, Adaptation, and Introgression

Advanced Science, EarlyView.
As a pilot phase of the Central Asian Genomic Diversity Project, whole‐genome sequencing of 166 individuals from 20 Central Asian and Afghan Hazara populations reveals fine‐scale substructure shaped by repeated trans‐Eurasian migration and admixture. Integrated analyses uncover post‐admixture adaptation, archaic introgression, and medically relevant ...
Mengge Wang, Shuhan Duan, Qiuxia Sun, Renkuan Tang, Lintao Luo, Jie Zhong, Zhaxylyk Sabitov, CAGDP Consortium†, Lan‐Hai Wei, Chao Liu, Maxat Zhabagin, Guanglin He   +11 more
wiley   +1 more source

Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration [PDF]

, 2013
Brain aging is associated with diminished circadian clock output and decreased expression of the core clock proteins, which regulate many aspects of cellular biochemistry and metabolism.
et al.,, Xilma Ortiz-Gonzalez, Bauer, Adam Q., Musiek, Erik S., Miranda M. Lim, Lee, Yool, Jee Hoon Roh, Erik D. Herzog, Wozniak, David F, Lim, Miranda M., Qi, Laura, Bauer, Adam Q, Dearborn, Joshua T, Garret A. FitzGerald, David F. Wozniak, Hogenesch, John B., Ortiz-Gonzalez, Xilma, Herzog, Erik D., Guangrui Yang, Yool Lee, Lim, Miranda M, Joshua T. Dearborn, Joseph P. Culver, Dearborn, Joshua T., Dikranian, Krikor, Erik S. Musiek, Roh, Jee Hoon, Laura Qi, Krikor Dikranian, Benoit I. Giasson, Giasson, Benoit I., Holtzman, David M., John B. Hogenesch, Culver, Joseph P., Musiek, Erik S, Culver, Joseph P, Weaver, David R., Oi, Laura, Wozniak, David F., FitzGerald, Garret A., Yang, Guangrui, Herzog, Erik D, Holtzman, David M, David M. Holtzman, David R. Weaver, Adam Q. Bauer   +45 more
core   +2 more sources

The functional interplay between protein kinase CK2 and CCA1 transcriptional activity is essential for clock temperature compensation in Arabidopsis. [PDF]

PLoS Genetics, 2010
Circadian rhythms are daily biological oscillations driven by an endogenous mechanism known as circadian clock. The protein kinase CK2 is one of the few clock components that is evolutionary conserved among different taxonomic groups.
Sergi Portolés, Paloma Más
doaj   +1 more source

RHINO: An Integrative Multi‐Omics Framework Linking Circadian Physiology to Precision Medicine

Advanced Science, EarlyView.
RHINO (RHythmic Interacting Network for multi‐Omics) is an integrative framework that maps circadian regulation across diverse genetic and disease contexts and prioritizes druggable circadian targets. Released as an AI‐powered interactive web portal, RHINO unifies genetic, regulatory, disease, and drug–target information, enabling context‐specific ...
Ying Chen, Chengxuan Chen, Dishu Zhou, Panpan Liu, Roberto E. López‐Valiente, Yuan Liu, Cam Mong La, Isabella Beraldo Xavier, Sean M. Hartig, Pradip Saha, Zheng Sun, Leng Han, Dongyin Guan   +12 more
wiley   +1 more source

Fly Cryptochrome and the Visual System [PDF]

, 2013
Cryptochromes are flavoproteins, structurally and evolutionarily related to photolyases, involved in development, magnetoreception and temporal organization of a variety of organisms.
Rossi, Alessandro
core  

Circadian Mutant Overtime Reveals F-box Protein FBXL3 Regulation of Cryptochrome and Period Gene Expression [PDF]

, 2007
SummaryUsing a forward genetics ENU mutagenesis screen for recessive mutations that affect circadian rhythmicity in the mouse, we isolated a long period (∼26 hr) circadian mutant named Overtime (Ovtm).
Lee, Choogon, Siepka, Sandra M., Park, Junghea, Kumar, Vivek, Takahashi, Joseph S., Song, Weimin, Yoo, Seung-Hee, Hu, Yinin   +7 more
core   +1 more source

High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase.

PLoS Biology, 2010
The circadian clock underlies daily rhythms of diverse physiological processes, and alterations in clock function have been linked to numerous pathologies.
Tsuyoshi Hirota, Jae Wook Lee, Warren G Lewis, Eric E Zhang, Ghislain Breton, Xianzhong Liu, Michael Garcia, Eric C Peters, Jean-Pierre Etchegaray, David Traver, Peter G Schultz, Steve A Kay   +11 more
doaj   +1 more source