Results 71 to 80 of about 43,915 (298)

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source

Thyroxine differentially modulates the peripheral clock: lessons from the human hair follicle [PDF]

, 2015
The human hair follicle (HF) exhibits peripheral clock activity, with knock-down of clock genes (BMAL1 and PER1) prolonging active hair growth (anagen) and increasing pigmentation.
Haslam, Iain S., Iain S Haslam, Jonathan A Hardman, Hardman, Jonathan A, Bessam Farjo (714627), Farjo, Bessam, Nilofer Farjo (714626), Nilofer Farjo, Jonathan A. Hardman (714625), Ralf Paus, Farjo, Nilofer, Bessam Farjo, Iain S. Haslam (452871), Haslam, Iain S, Hardman, Jonathan A., Paus, Ralf, Ralf Paus (261703)   +16 more
core   +1 more source

Suppression of PERIOD protein abundance and circadian cycling by the Drosophila clock mutation timeless. [PDF]

The EMBO Journal, 1995
The timeless mutation (tim) leads to loss of circadian behavioral rhythms in Drosophila melanogaster. The effects of tim on rhythmicity involve interactions with period (per), a second essential clock gene, as the tim mutation suppresses circadian oscillations of per transcription and blocks nuclear localization of a PER reporter protein.
J L, Price, M E, Dembinska, M W, Young, M, Rosbash   +3 more
openaire   +2 more sources

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

Advanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu, Gaole Dai, Sen Zhu, Shuai Zhang, Tingting Wang, Yuan Meng, Fang Yang, Xiaoyi Han, Hui Wang, Hao Kou, Dan Xu   +10 more
wiley   +1 more source

Setting Clock Speed in Mammals: The CK1ε tau Mutation in Mice Accelerates Circadian Pacemakers by Selectively Destabilizing PERIOD Proteins [PDF]

, 2008
The intrinsic period of circadian clocks is their defining adaptive property. To identify the biochemical mechanisms whereby casein kinase1 (CK1) determines circadian period in mammals, we created mouse null and tau mutants of Ck1 epsilon.
Maywood, E.S., Yoo, S.-H., Boot-Handford, R.P., Piggins, Hugh D., Piggins, H.D., Loudon, Andrew S I; id_orcid, Loudon, Andrew S.I., Logunova, L., Meng, Qing Jun; id_orcid, Logunova, Larisa, Bechtold, David A., Brown, T.M., Lebiecki, J., Lebiecki, Jake, Glossop, N.R.J., Virshup, D.M., Loudon, A.S.I., Takahashi, J.S., Meng, Q.-J., Brown, Timothy M., Boot-Handford, Raymond P.; id_orcid, Hastings, M.H., Glossop, Nicholas R J, Gallego, Monica, Maywood, Elizabeth S., Gallego, M., Sládek, M., Takahashi, Joseph S., Boot-Handford, Raymond P., Yoo, Seung Hee, Hastings, Michael H., Bechtold, David A.; id_orcid, Chesham, J.E., Yoo, Seung-Hee, Virshup, David M., Glossop, Nicholas R.J., Chesham, Johanna E., Bechtold, D.A., Sládek, Martin, Semikhodskii, Andrei S., Semikhodskii, A.S., Meng, Qing-Jun   +41 more
core   +1 more source

Circadian period is compensated for repressor protein turnover rates in single cells

Proceedings of the National Academy of Sciences
Most mammalian cells have molecular circadian clocks that generate widespread rhythms in transcript and protein abundance. While circadian clocks are robust to fluctuations in the cellular environment, little is known about the mechanisms by which the circadian period compensates for fluctuating metabolic states.
Christian H. Gabriel, Marta del Olmo, Arunya Rizki Widini, Rashin Roshanbin, Jonas Woyde, Ebrahim Hamza, Nica-Nicoleta Gutu, Amin Zehtabian, Helge Ewers, Adrian Granada, Hanspeter Herzel, Achim Kramer   +11 more
openaire   +2 more sources

A High‐Throughput Live Imaging Platform to Investigate Circuit‐Dependent Regulation of Circadian Rhythms in Brain Tissue

Advanced Science, EarlyView.
Biological rhythms coordinate physiology, from genes to behavior. Study of circadian rhythms in brain tissue is constrained by limited throughput and spatial and temporal information quality. A new platform for high‐throughput, long‐term multiplexed fluorescent live imaging of circadian rhythms in brain slices is introduced.
Marco Ferrari, Natalie Ness, Julieta Acosta, Marco Brancaccio   +3 more
wiley   +1 more source

Targeting ANGPTL3 and IL‐33/ST2 Ameliorates Diabetic Kidney Disease by Reducing Lipotoxicity, Alleviating Inflammation and Inhibiting Fibrosis

Advanced Science, EarlyView.
Dual targeting of ANGPTL3 and IL‐33/ST2 attenuates diabetic kidney disease by reprogramming lipid–inflammatory crosstalk. This strategy reduces renal lipotoxicity, suppresses inflammatory activation, and limits fibrotic remodeling, thereby preserving kidney structure and function and highlighting a mechanism‐guided therapeutic approach for metabolic ...
Zhuojin Li, Zhonglian Cao, Rongrui Zhou, Xu Cheng, Xiaozhi Hu, Shuwen Xu, Zihan Dou, Ling Du, Dianwen Ju   +8 more
wiley   +1 more source

The ubiquitin-proteasome system in circadian regulation

Frontiers in Neuroscience
To align sleep–wake behavior and internal physiology with the Earth’s 24-h light–dark cycle, organisms rely on circadian clocks–endogenous timekeeping systems that anticipate and adapt to daily environmental changes.
Kara M. Costanzo, Matthew V. Prifti, Sokol V. Todi, Sokol V. Todi, Ryan D. Mohan   +4 more
doaj   +1 more source

The tail of cryptochromes: an intrinsically disordered cog within the mammalian circadian clock

Cell Communication and Signaling, 2020
Cryptochrome (CRY) proteins play an essential role in regulating mammalian circadian rhythms. CRY is composed of a structured N-terminal domain known as the photolyase homology region (PHR), which is tethered to an intrinsically disordered C-terminal ...
Gian Carlo G. Parico, Carrie L. Partch
doaj   +1 more source