Results 61 to 70 of about 43,915 (298)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Magel2, a Prader-Willi syndrome candidate gene, modulates the activities of circadian rhythm proteins in cultured cells

Journal of Circadian Rhythms, 2011
Background The Magel2 gene is most highly expressed in the suprachiasmatic nucleus of the hypothalamus, where its expression cycles in a circadian pattern comparable to that of clock-controlled genes.
Devos Julia, Weselake Sara V, Wevrick Rachel   +2 more
doaj   +1 more source

Nuclear Envelope Protein MAN1 Regulates the Drosophila Circadian Clock via Period

Neuroscience Bulletin, 2019
Almost all organisms exhibit ~24-h rhythms, or circadian rhythms, in a plentitude of biological processes. These rhythms are driven by endogenous molecular clocks consisting of a series of transcriptional and translational feedback loops. Previously, we have shown that the inner nuclear membrane protein MAN1 regulates this clock and thus the locomotor ...
Bei, Bu, Weiwei, He, Li, Song, Luoying, Zhang   +3 more
openaire   +3 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Novel mechanisms operating in the central pacemaker and in the light-synchronization pathway of Drosophila’s circadian clock [PDF]

, 2011
PhDMost organisms display circadian rhythms of approximately 24 hours in many aspects of their physiology and behaviour. The synchronization between their internal rhythm and the environmental light-dark cycles is essential for an organism’s survival ...
Chen, Ko-Fan
core  

Temperature compensation of the Arabidopsis circadian clock

npj Biological Timing and Sleep
The circadian clock is an endogenous, self-sustaining oscillator with a period of approximately 24 h. This timekeeping system helps organisms align their physiologies and behaviors with the day-night cycle.
Akari E. Maeda, Norihito Nakamichi
doaj   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work‐Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models

Advanced Science, EarlyView.
This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang, Yifan Dou, Yingnan Lei, Shuang Liu, Jialin Zhou, Jiaping Li, Huadong Xu, Lingfang Feng, Yongxin Li, Chuyan Zhang, Tao Li, Jianfei Wang, Xing Zhang, Xinran Wang, Luyao Liu, Jingjing Zhang, Jianlin Lou   +16 more
wiley   +1 more source

Isolation of new genes involved in temperature synchronization of the circadian clock of Drosophila melanogaster [PDF]

, 2010
PhDCircadian clocks regulate behaviour and physiology of many organisms and keep them in synchrony with the environment. Drosophila's circadian clock is mainly synchronized by natural light-dark cycles and temperature fluctuations, both at molecular
Simoni, Alekos
core  

Circadian rhythms of ethylene emission in Arabidopsis [PDF]

, 2004
Ethylene controls multiple physiological processes in plants, including cell elongation. Consequently, ethylene synthesis is regulated by internal and external signals.
Harren, Frans J M, DOWSON-DAY, MJ, Thain, Simon C, Van Der Straeten, Dominique, HARREN, FJM, TOBIN, EM, THAIN, SC, Tobin, E.M., Dowson-Day, Mandy J, LAARHOVEN, LJJ, WANG, ZY, Tobin, Elaine M, Wang, Z.Y., Laarhoven, L.J.J., Laarhoven, Lucas J J, Harren, F.J.M., Dowson-Day, M.J., Wang, Zhi-Yong, Millar, A.J., Vandenbussche, Filip, Millar, Andrew J; id_orcid, Thain, S.C., MILLAR, AJ, Van Der Straeten, D., Vandenbussche, F.P.H.A.   +24 more
core   +1 more source