Results 141 to 150 of about 356,744 (339)

Existence of solutions for a biological model using topological degree theory [PDF]

arXiv, 2016
Topological degree theory is a useful tool for studying systems of differential equations. In this work, a biological model is considered. Specifically, we prove the existence of positive T-periodic solutions of a system of delay differential equations for a model with feedback arising on Circadian oscillations in the Drosophila period gene protein.
arxiv  

Using the diel cycle of ocean microbes to better understand their biogeochemical functions

Limnology and Oceanography Letters, EarlyView.
Abstract The daily cycle of solar radiation has a profound influence in structuring the physiology of microbes in the euphotic zone and subsequently setting the degree of coupling across trophic levels within ocean ecosystems. There has been an upsurge of interest in the biological role of the diel cycle and the ability to probe it using molecular ...
Philip W. Boyd, Benjamin A. S. Van Mooy
wiley   +1 more source

Decoys provide a scalable platform for the identification of plant E3 ubiquitin ligases that regulate circadian function

eLife, 2019
The circadian clock relies on regulated degradation of clock proteins to maintain rhythmicity. Despite this, we know few components that mediate protein degradation.
Ann Feke, Wei Liu, Jing Hong, Man-Wah Li, Chin-Mei Lee, Elton K Zhou, Joshua M Gendron   +6 more
doaj   +1 more source

The circadian clock protein Period 1: a candidate master regulator of renal gene expression

The FASEB Journal, 2010
The goal of the present study was to define the role of the circadian clock protein Period 1 (Per1) in the regulation of renal epithelial transport, using a model of the cortical collecting duct (CCD). Per1 regulates expression of αENaC, the α subunit of the renal epithelial Na+ channel (Gumz et al. JCI 2009). To determine if Per1 regulates other genes
Brian D. Cain, Charles S. Wingo, Megan M. Greenlee, Michelle L. Gumz, I. Jeanette Lynch   +4 more
openaire   +2 more sources

Evidence of Involvement of the Calcitonin Gene‐Related Peptide in Restless Legs Syndrome

Movement Disorders, EarlyView.
Abstract Background Restless legs syndrome (RLS) is a common sensory‐motor disorder characterized by an urge to move the legs, often with unpleasant sensations, particularly during rest. Current treatments include iron supplementation, dopamine agonists, and opioids, but new therapeutic approaches are needed.
Maria P. Mogavero, Mojibola Fowowe, Akeem Sanni, Mona Goli, Giuseppe Lanza, Francesca L'Episcopo, Luigi Ferini‐Strambi, Yehia Mechref, Raffaele Ferri   +8 more
wiley   +1 more source

Coordination between Differentially Regulated Circadian Clocks Generates Rhythmic Behavior.

Cold Spring Harbor Perspectives in Biology, 2018
Specialized groups of neurons in the brain are key mediators of circadian rhythms, receiving daily environmental cues and communicating those signals to other tissues in the organism for entrainment and to organize circadian physiology.
Deniz Top, M. W. Young
semanticscholar   +1 more source

Nutraceutical Blends Promote Weight Loss, Inflammation Reduction, and Better Sleep: The Role of Faecalibacterium prausnitzii in Overweight Adults–A Double‐Blind Trial

Molecular Nutrition &Food Research, EarlyView.
This study explored how a 90‐day nutraceutical blend with prebiotics, minerals, and silymarin affects the gut‐brain axis in overweight adults. Results showed improved gut microbiota, reduced inflammation, and better sleep, mood, and quality of life, suggesting a strong link between gut health and mental well‐being.
Aline Boveto Santamarina, Victor Nehmi Filho, Jéssica Alves de Freitas, Lucas Augusto Moysés Franco, Roberta Cristina Martins, Joyce Vanessa Fonseca, José Antônio Orellana Turri, Mariana Tedesco Hufnagel, Daniel Pecoraro Demarque, Bruna Fernanda Rio Branco da Silva, Arianne Fagotti Gusmão, Eloísa Helena Ribeiro Olivieri, Erica de Souza, Esther Alves de Souza, José Pinhata Otoch, Ana Flávia Marçal Pessoa   +15 more
wiley   +1 more source

A mechanism for robust circadian timekeeping via stoichiometric balance

Molecular Systems Biology, 2012
Circadian (∼24 h) timekeeping is essential for the lives of many organisms. To understand the biochemical mechanisms of this timekeeping, we have developed a detailed mathematical model of the mammalian circadian clock.
Jae Kyoung Kim, Daniel B Forger
doaj   +1 more source

Nano‐Biosensors for Continuous Cognitive and Stress Monitoring: Applications in Learning and Mental Well‐Being

Nano Select, EarlyView.
Nano‐biosensors offer real‐time monitoring of cognitive and emotional states through biomarkers like cortisol and dopamine. They enhance personalized learning, mental health interventions, and daily performance across sectors. Integrated into wearables and IoT, they promise a transformative impact while raising ethical, technological, and regulatory ...
Priscilla Adomako Gyasi, Jesse Nii Okai Amu‐Darko, Binghai Sun, Eliasu Issaka, Seth Yeboah Ntim, Michael Enyan, Shahid Hussain   +6 more
wiley   +1 more source

Analyses of and Oscillations in a Model of Breast Cancer Progression Reveal Changes With Malignancy

Integrative Cancer Therapies, 2019
From an epidemiological standpoint, disruptions to circadian rhythms have been shown to contribute to the development of various disease pathologies, including breast cancer.
Hui-Hsien Lin MS, Maan Qraitem, Yue Lian, Stephanie R. Taylor PhD, Michelle E. Farkas PhD   +4 more
doaj   +1 more source