Results 271 to 280 of about 85,043 (305)

Circadian PERIOD proteins regulate TC-DSB repair through anchoring to the nuclear envelope

2023
AbstractRepair of DNA Double-Strand Breaks (DSBs) produced in transcriptionally active chromatin occurs through a poorly characterized pathway called Transcription-Coupled DSB repair (TC-DSBR). Here, using a screening approach scoring multiple outputs in human cells, we identified proteins from the PERIOD complex, a key module ensuring circadian ...
Le Bozec, Benjamin, Guitton-Sert, Laure, Collins, Sarah, Finoux, Anne-Laure, Payrault, Charlotte, Frison, Jessica, Carette, Romane, Rocher, Vincent, Guillou, Emmanuelle, Arnould, Coline, Guénolé, Aude, Aguirrebengoa, Marion, Lazar, Ikrame, Marnef, Aline, Frit, Philippe, Calsou, Patrick, Mangeat, Thomas, Puget, Nadine, Legube, Gaëlle   +18 more
openaire   +2 more sources

Purification and Analysis of PERIOD Protein Complexes of the Mammalian Circadian Clock

2015
In mammals, circadian rhythms are generated at least in part by a cell-autonomous transcriptional feedback loop in which the three PERIOD (PER) and two CRYPTOCHROME (CRY) proteins inhibit the activity of the dimeric transcription factor CLOCK-BMAL1, thereby repressing their own expression.
Jin Young, Kim, Pieter Bas, Kwak, Michael, Gebert, Hao A, Duong, Charles J, Weitz   +4 more
openaire   +2 more sources

Temperature Compensation of Circadian Rhythms: Control of the Period in a Model for Circadian Oscillations of the Per Protein in Drosophila

Chronobiology International, 1997
The factors affecting the period are examined in a model for circadian oscillations of the period protein (PER) in Drosophila. The model for the circadian clock is based on multiple phosphorylation of PER and on the negative feedback exerted by PER on the transcription of the period (per) gene.
Leloup, Jean-Christophe, Goldbeter, Albert   +1 more
openaire   +2 more sources

Circadian rhythms. Decoupling circadian clock protein turnover from circadian period determination.

Science (New York, N.Y.), 2015
The mechanistic basis of eukaryotic circadian oscillators in model systems as diverse as Neurospora, Drosophila, and mammalian cells is thought to be a transcription-and-translation-based negative feedback loop, wherein progressive and controlled phosphorylation of one or more negative elements ultimately elicits their own proteasome-mediated ...
Luis F, Larrondo, Consuelo, Olivares-Yañez, Christopher L, Baker, Jennifer J, Loros, Jay C, Dunlap   +4 more
openaire   +1 more source

A model for circadian oscillations in the Drosophila period protein (PER)

Proceedings of the Royal Society of London. Series B: Biological Sciences, 1995
The mechanism of circadian oscillations in the period protein (PER) in Drosophila is investigated by means of a theoretical model. Taking into account recent experimental observations, the model for the circadian clock is based on multiple phosphorylation of PER and on the negative feedback exerted by PER on the transcription of the period (per) gene ...
openaire   +2 more sources

Circadian Cycling of a PERIOD-β-galactosidase Fusion Protein in Drosophila: Evidence for Cyclical Degradation

Journal of Biological Rhythms, 1997
The authors analyzed circadian features of two period-lacZ (per-lacZ) fusion genes in transgenic strains of Drosophila. Both genes manifest circadian fluctuations of mRNA levels, but fluctuations of only the larger chimeric protein are apparent. Fusion protein cycling is indistinguishable from the behavior of wild-type per protein (PER), including ...
M E, Dembinska, R, Stanewsky, J C, Hall, M, Rosbash   +3 more
openaire   +2 more sources

An antibody to the Drosophila period protein recognizes circadian pacemaker neurons in Aplysia and Bulla

Neuron, 1989
The molecular mechanisms of the pacemakers underlying circadian rhythms are not well understood. One molecule that presumably functions in the circadian clock of Drosophila is the product of the period (per) gene, which dramatically affects biological rhythms when mutated.
Siwicki, Kathleen King, Strack, S., Rosbash, M., Hall, J. C., Jacklet, J. W.   +4 more
openaire   +3 more sources

Phase Shifting of the Circadian Clock by Induction of the Drosophila period Protein

Science, 1994
Virtually all organisms manifest circadian (24-hour) rhythms, governed by an ill-defined endogenous pacemaker or clock. Several lines of evidence suggest that the Drosophila melanogaster period gene product PER is a clock component.
I, Edery, J E, Rutila, M, Rosbash
openaire   +2 more sources

Circadian PERIOD proteins sculpt the mammalian alternative splicing landscape

AbstractMammalian circadian oscillators are driven by a transcription-translation feedback loop where CLOCK:BMAL1 activity is repressed by the PER:CRY complex. While transcriptional regulation by PER is well established, the role of circadian feedback in co- and post- transcriptional processes remains unclear.
L Chikhaoui, K Mamgain, M Seki, C Blanco, F Sassolas, E Folco, D Sery, Y Suzuki, B Ananthasubramaniam, K Padmanabhan   +9 more
openaire   +1 more source