Results 261 to 270 of about 43,915 (298)
Human casein kinase Iδ phosphorylation of human circadian clock proteins period 1 and 2 [PDF]
FEBS Letters, 2001 Casein kinase Iϵ (CKIϵ), a central component of the circadian clock, interacts with and phosphorylates human period protein 1 (hPER1) [Keesler, G.A. et al. (2000) NeuroReport 5, 951–955]. A mutation in CKIϵ causes a shortened circadian period in Syrian Golden hamster. We have now extended our previous studies to show that human casein kinase Iδ (hCKIδ),
David M Virshup, Zepeng Yao
exaly +4 more sources
A Small Molecule Modulates Circadian Rhythms through Phosphorylation of the Period Protein [PDF]
Angewandte Chemie - International Edition, 2011 Time shift A high-throughput cell-based screen identified a benzothiazole analogue, LH846, which induces period lengthening of the circadian rhythm. Affinity chromatography coupled with mass spectrometry and genomic analysis identified protein kinase CKIδ as the biological target of LH846 (see picture).
Jae Wook Lee +2 more
exaly +3 more sources
CAVIN‐3 regulates circadian period length and PER:CRY protein abundance and interactions [PDF]
EMBO Reports, 2012 In mammals, transcriptional autorepression by Period (PER) and Cryptochrome (CRY) protein complexes is essential for the generation of circadian rhythms. We have identified CAVIN-3 as a new, cytoplasmic PER2-interacting protein influencing circadian clock properties.
Teymuras V Kurzchalia +2 more
exaly +5 more sources
Circadian control of oscillations in mitochondrial rate-limiting enzymes and nutrient utilization by PERIOD proteins [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2016 Significance Mitochondria are major cellular energy suppliers and have to cope with changes in nutrient supply and energy demand that naturally occur throughout the day. We obtained the first, to our knowledge, comprehensive mitochondrial proteome around the clock and identified extensive oscillations in mitochondrial protein abundance that ...
Maria S Robles +2 more
exaly +4 more sources
Dependence of the period on the rate of protein degradation in minimal models for circadian oscillations [PDF]
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2009 Circadian rhythms, which occur spontaneously with a period of about 24 h in a variety of organisms, allow their adaptation to the periodic variations of the environment. These rhythms are generated by a genetic regulatory network involving a negative feedback loop on transcription.
Gérard, Claude +2 more
openaire +3 more sources
FEBS Letters, 2011 The phenotypes of mice carrying clock gene mutations have been critical to understanding the mammalian clock function. However, behavior does not necessarily reflect cell-autonomous clock phenotypes, because of the hierarchical dominance of the central clock.
Masashi Kitazawa, Seiichi Hashimoto
exaly +3 more sources