Results 131 to 140 of about 241,774 (311)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
PERIOD BY THE WAVE-GROUP METHOD
Coastal Engineering Proceedings, 1972 The wave-group period, T , is obtained by a eimple manual procedure from the periodic wave groupff'and sequences that appear in strip-chart records. A dozen or more values are commonly derived from a 20-minute record. When plotted as a time-series, T values form patterns that represent individual wave trains, each generated by a synoptic weather event.
openaire +2 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Results in ChemistryThe Periodic Table of Elements, a cornerstone of chemical sciences, has traditionally been structured based on the physicochemical properties of its elements.
Sebastián Consuegra-Jiménez +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
, 2016 Educação Superior::Ciências Exatas e da Terra::QuímicaThis educational object is a video class about the groups of the periodic table and the electronic configuration of ...
Khan Academy
core
Periodic Groups via Orbital Graphs [PDF]
, 2019 In this work, we introduce a method of proving when an infinite group of homeomorphisms of a Cantor set is periodic using the geometry of its orbital graphs.
Cantu, Justin Colt
core
Cohomological periodicities of crystallographic groups
Journal of Algebra, 2016 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +2 more sources
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source