Results 71 to 80 of about 1,473,692 (365)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Practical challenges in data‐driven interpolation: Dealing with noise, enforcing stability, and computing realizations

International Journal of Adaptive Control and Signal Processing, EarlyView., 2023
Summary In this contribution, we propose a detailed study of interpolation‐based data‐driven methods that are of relevance in the model reduction and also in the systems and control communities. The data are given by samples of the transfer function of the underlying (unknown) model, that is, we analyze frequency‐response data.
Quirin Aumann, Ion Victor Gosea
wiley   +1 more source

Periodic orbits related to the equilibrium points in the potential of Irregular-shaped minor celestial bodies

Results in Physics, 2019
We presented an overview of detailed continuation results of periodic orbit families which emanate from the equilibrium points (EPs) of irregular-shaped minor celestial bodies (hereafter called minor bodies).
Yu Jiang, Hexi Baoyin
doaj  

Bifurcation of Nongeneric Homoclinic Orbit Accompanied by Pitchfork Bifurcation

Abstract and Applied Analysis, 2014
The bifurcation of a nongeneric homoclinic orbit (i.e., the orbit comes from the equilibrium along the unstable manifold instead of the center manifold) connecting a nonhyperbolic equilibrium is investigated, and the nonhyperbolic equilibrium undergoes ...
Fengjie Geng, Song Li
doaj   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Statistical properties of periodic orbits in 4-disk billiard system: pruning-proof property [PDF]

, 2005
Periodic orbit theory for classical hyperbolic system is very significant matter of how we can interpret spectral statistics in terms of semiclassical theory. Although pruning is significant and generic property for almost all hyperbolic systems, pruning-
Alekseev, Aurich, Aurich, Berry, Berry, Bohigas, Brack, Braun, Bunimovich, Bunimovich, Casati, Chen, Cvitanović, Cvitanović, Davis, Gaspard, Giannoni, Gutzwiller, Gutzwiller, Gutzwiller, Gutzwiller, Gutzwiller, Gutzwiller, Gutzwiller, Gutzwiller, Gutzwiller, Haake, Hagiwara, Hagiwara, Hannay, Hansen, Hansen, Harayama, Heusler, Ikeda, Ioss, Ishii, Ishii, Leboeuf, Lerner, Mehta, Miller, Milnor, Morita, Müller, Müller, Müller, Ozorio de Almeida, Parry, Pollicott, Pollicott, Primack, Richter, Sano, Shudo, Sieber, Sieber, Sieber, Sieber, Sieber, Spehner, Stöckmann, Szász, Takeshi Asamizuya, Tanner, Turek, Turek, Xia   +67 more
core   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Kuramoto Phase Model with Inertia: Bifurcations Leading to the Loss of Synchrony and to the Emergence of Chaos

Моделирование и анализ информационных систем, 2015
We consider a finite-dimensional model of phase oscillators with inertia in the case of star configuration of coupling. The system of equations is reduced to a nonlinearly coupled system of pendulum equations.
V. N. Belykh, M. I. Bolotov, G. V. Osipov   +2 more
doaj   +1 more source

Orbit period modulation for relative motion using continuous low thrust in the two-body and restricted three-body problems [PDF]

, 2018
This paper presents rich new families of relative orbits for spacecraft formation flight generated through the application of continuous thrust with only minimal intervention into the dynamics of the problem.
Arnot, C.S., Biggs, J., Macdonald, M., McInnes, C.R., McKay, R.J.   +4 more
core   +2 more sources

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source