Results 91 to 100 of about 1,445,125 (331)

Putting the axonal periodic scaffold in order

open access: yesCurrent Opinion in Neurobiology, 2021
Neurons rely on a unique organization of their cytoskeleton to build, maintain and transform their extraordinarily intricate shapes. After decades of research on the neuronal cytoskeleton, it is exciting that novel assemblies are still discovered thanks to progress in cellular imaging methods. Indeed, super-resolution microscopy has revealed that axons
openaire   +3 more sources

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

On periodic solutions of fractional-order differential systems with a fixed length of sliding memory

open access: yesJournal of Innovative Applied Mathematics and Computational Sciences, 2021
The fractional-order derivative of a non-constant periodic function is not periodic with the same period. Consequently, any time-invariant fractional-order systems do not have a non-constant periodic solution.
Safa Bourafa   +2 more
doaj  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

open access: yesFEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim   +11 more
wiley   +1 more source

ON SECOND-ORDER ALMOST-PERIODIC ELLIPTIC OPERATORS

open access: yesJournal of the London Mathematical Society, 2001
The paper considers second-order, strongly elliptic, operators H with complex almost-periodic coefficients in divergence form on Rd. First, it is proved that the corresponding heat kernel is Hölder continuous and Gaussian bounds are derived with the correct small and large time asymptotic behaviour on the kernel and its Hölder derivatives. Secondly,
Robinson, Derek   +2 more
openaire   +2 more sources

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

Periodic boundary value problems of second order random differential equations

open access: yesElectronic Journal of Qualitative Theory of Differential Equations, 2009
In this paper, an existence and the existence of extremal random solutions are proved for a periodic boundary value problem of second order ordinary random differential equations.
Bapurao Dhage   +2 more
doaj   +1 more source

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