Results 101 to 110 of about 982,799 (263)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Almost-periodic solution for BAM neural networks [PDF]

open access: yesSurveys in Mathematics and its Applications, 2009
In this paper, we study the existence and uniqueness solution and investigate the conditions that make it almost-periodic solution for BAM neural networks with retarded delays.
Hamid A. Jalab, Rabha W. Ibrahim
doaj  

Some New Exact Solutions of (1+2)-Dimensional Sine-Gordon Equation

open access: yesAbstract and Applied Analysis, 2014
We use a generalized tanh function expansion method and a direct method to study the analytical solutions of the (1+2)-dimensional sine Gordon (2DsG) equation.
Wei-Xiong Chen, Ji Lin
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Periodic solution for ϕ-Laplacian neutral differential equation

open access: yesOpen Mathematics, 2019
This paper is devoted to the existence of a periodic solution for ϕ-Laplacian neutral differential equation as follows (ϕ(x(t)−cx(t−τ))′)′=f(t,x(t),x′(t)).$$\begin{array}{} (\phi(x(t)-cx(t-\tau))')'=f(t,x(t),x'(t)). \end{array}$$
Yao Shaowen, Cheng Zhibo
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The Elusive Liapunov Periodic Solutions

open access: yesQualitative Theory of Dynamical Systems, 2015
We illustrate the use of regular and singular reduction methods in conjunction with classical perturbation theory to find periodic solutions of Hamiltonian systems. In particular, we use these methods to find families of periodic solutions when the classical Liapunov center theorem fails due to a resonance.
Meyer, Kenneth R.   +2 more
openaire   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Periodic Systems Dependent on Parameters

open access: yesJournal of Inequalities and Applications, 2010
This paper is concerned with a periodic system dependent on parameter. We study differentiability with respect to parameters of the periodic solution of the system. Applying a fixed point theorem and the results regarding parameters for C0-semigroups, we
Min He
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

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