Results 101 to 110 of about 5,607,834 (304)

Evaluation of amplitude of low frequency spectrum components using ordinary accelerometers [PDF]

open access: yesActa Montanistica Slovaca, 2008
The paper deals with measurement and further evaluation of amplitude of spectrum components with a frequency ranging from 0.2Hz to 1Hz for pseudo-periodical processes. For example a car engine can produce random burst shaking if power contribution to the
Petr Kočí
doaj  

Healing after horizontal root fractures: 3 cases with 2-year follow-up

open access: yesRestorative Dentistry & Endodontics, 2014
Among dental traumas, horizontal root fractures are relatively uncommon injuries. Proper initial management and periodical evaluation is essential for the successful treatment of a root-fractured tooth.
Yoorina Choi   +4 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Avaliação da coleção de periódicos doados à biblioteca da FEA-IEI da UFRJ: critérios de seleção e descarte

open access: yesCiência da Informação, 1993
Avalia quantitativamente a coleção de periódicos doados à Biblioteca da Faculdade de Economia e Administração e Instituto de Economia (FEAIEI) da Universidade Federal do Rio de Janeiro (UFRJ), pela freqüência de uso por meio de empréstimos domiciliares e
Maria Aparecida de Andrade Teixeira   +1 more
doaj  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Evaluation of Scaling Efforts in CGIAR: Technical Note

open access: yes
CGIAR has maintained a long-standing commitment to scaling the public benefits of its innovations and has recently reinforced this priority. This renewed emphasis has generated an increasing need for the systematic evaluation of scaling efforts.
CGIAR Independent Advisory and Evaluation Service
core  

The evaluation of dermatologic education in the postgraduate period [PDF]

open access: yesMedical Teacher, 2006
Atilla, Ozcan   +3 more
openaire   +2 more sources

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