Results 61 to 70 of about 127,295 (353)

Trend Information System Research Topics in the SINTA Journal for the Period 2015-2019

open access: yesJurnal Sisfokom (Sistem Informasi dan Komputer), 2021
Information systems discipline has developed rapidly over time. Based on 533 information systems study programs in Indonesia, it is possible to have a variety of information systems research topics. However, there is no research on information system topic trends in Indonesia.
Yusuf Amrozi   +2 more
openaire   +4 more sources

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

Discrete period matrices and related topics

open access: yes, 2001
We continue our investigation of Discrete Riemann Surfaces with the discussion of the discrete analogs of period matrices, Riemann's bilinear relations, exponential of constant argument, series and electrical moves. We show that given a refining sequence of critical maps, the discrete period matrix converges to the continuous one.
openaire   +2 more sources

Decimal periods and their tables: A German research topic (1765–1801)

open access: yesHistoria Mathematica, 2009
At the beginning of the 18th century, several mathematicians noted regularities in the decimal expansions of common fractions. Rules of thumb were set up, but it was only from 1760 onwards that the first attempts to try to establish a coherent theory of periodic decimal fractions appeared. J.H.
openaire   +3 more sources

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

open access: yesMolecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla   +5 more
wiley   +1 more source

Scholarly publishing depends on peer reviewers

open access: yesPharmacy Practice, 2018
The peer-review crisis is posing a risk to the scholarly peer-reviewed journal system. Journals have to ask many potential peer reviewers to obtain a minimum acceptable number of peers accepting reviewing a manuscript.
Fernandez-Llimos F   +1 more
doaj   +1 more source

National Newspaper Portrayal of U.S. Nursing Homes: Periodic Treatment of Topic and Tone [PDF]

open access: yesThe Milbank Quarterly, 2012
Context: Although observers have long highlighted the relationship of public distrust, government regulation, and media depictions of nursing‐home scandals, no study has systematically analyzed the way in which nursing homes have been portrayed in the national media.
Julia Rozanova   +7 more
openaire   +3 more sources

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