Results 61 to 70 of about 31,579 (302)

Orchestrated Engineered Polyphenol‐Peptide Condensates Coupled With β‐GP Reverses Diabetic Osteoporosis by Remodeling Mitophagy

Advanced Science, EarlyView.
A multifunctional β‐GP@EGCG‐E7 nanoplatform is engineered by polyphenol–peptide condensation and phosphate loading. Bone‐targeted delivery, antioxidant and anti‐inflammatory activity, and mitophagy restoration are integrated in one system, enabling protection of osteoblasts and endothelial cells and promoting bone regeneration under diabetic ...
Xiuyun Xu, Meiqin Zhang, Ting Wu, Erfan Wei, Andrei Y. Hancharou, Zeying Wang, Zijuan Wang, Letian Lv, Likun Wu, Xingtong Pan, Qiyue Zhu, Xinyi Dong, Hao Liu, Yongsheng Zhou   +13 more
wiley   +1 more source

Periodontal Wound Healing and Regeneration: Insights for Engineering New Therapeutic Approaches

Frontiers in Dental Medicine, 2022
Periodontitis is a widespread inflammatory disease that leads to loss of the tooth supporting periodontal tissues. The few therapies available to regenerate periodontal tissues have high costs and inherent limitations, inspiring the development of new ...
David Fraser, David Fraser, Jack Caton, Danielle S. W. Benoit, Danielle S. W. Benoit, Danielle S. W. Benoit, Danielle S. W. Benoit, Danielle S. W. Benoit   +7 more
doaj   +1 more source

Which biomaterials may promote periodontal regeneration in intrabony periodontal defects? A systematic review of preclinical studies.

, 2014
OBJECTIVE To systematically analyze the regenerative effect of the available biomaterials either alone or in various combinations for the treatment of periodontal intrabony defects as evaluated in preclinical histologic studies.
Ivanovic, Aleksandar, Miron, Richard, Sculean, Anton, Nikou, George, Nikolidakis, Dimitris   +4 more
core   +1 more source

A Blood‐Derived Double‐Network Hydrogel with Robust Wet Adhesion for Keratinized Mucosa Regeneration via Neutrophil Phenotype Reprogramming and Mechanophysical Niche Modulation

Advanced Science, EarlyView.
The iPRF‐MA/Alg‐NHS/Lut@EGCG (PGAE) double‐network hydrogel achieves durable wet adhesion in the oral environment. It simultaneously reprograms neutrophils from NETosis to phagocytosis for biofilm clearance, and activates the FAK‐RhoA‐YAP mechanotransduction pathway in gingival fibroblasts to drive extracellular matrix remodeling, thereby promoting ...
Sicong Ren, Xinting Yang, Jingxia Chen, Yihan Wang, Jian Feng, Jing Zhou, Jiaxin Luo, Jingjie Zhai, Quan Lin, Yanmin Zhou   +9 more
wiley   +1 more source

Nanocrystalline hydroxyapatite in periodontal bone regeneration: A systematic review

Saudi Dental Journal, 2022
Background: Periodontal diseases when persistent, results in periodontal pockets, attachment loss and progressive destruction of the alveolar bone.
Marwa Y. Shaheen
doaj   +1 more source

Sustained delivery of growth factors and alendronate using partially demineralized dentin matrix for endogenous periodontal regeneration

, 2021
The decreasing number and reduced osteogenic differentiation capacity of mesenchymal stem cells (MSCs) and the excessive proliferation of osteoclasts in periodontal defects lead to difficulty in periodontal regeneration.
Lingling Chen, Gao, Xianling, Liu, Xuemin, Chen, Lingling, Xiao, Yin, Xuemin Liu, Xu, Hockin HK, Meiliang Guan, Shuheng Huang, Xuetao Shi, Shi, Xuetao, Hockin H.K. Xu, Qiting Huang, Lin, Zhengmei, Yin Xiao, Huang, Qiting, Zhengmei Lin, Guan, Meiliang, Xianling Gao, Huang, Shuheng   +19 more
core   +1 more source

Beyond Potency: Emerging Determinants and Optimization Strategies Enhancing Therapeutic Efficacy of Adult Stem Cells

Advanced Science, EarlyView.
Adult stem cell therapy requires more than high in vitro potency. This review proposes a systems framework in which cell‐intrinsic programs, instructive microenvironmental cues, and pre‐/post‐delivery engineering are co‐designed under standardized translational rules.
Soo‐Rim Kim, Yun Jae Jung, Hwa‐Yong Lee   +2 more
wiley   +1 more source

Antimicrobial Efficacy and Soft-Tissue Safety of Air-Polishing Powders in Periodontal Therapy: A Narrative Review

Journal of Functional Biomaterials
Periodontitis is a biofilm-induced multifactorial disease characterized by non-reversible damage of the periodontal tissues. Dysbiosis of the subgingival microbiota plays a crucial role in periodontitis. In this regard, conventional periodontal treatment
Ștefania Sorina Ifrim, Alina Bârdea, Alexandra Roman, Andrada Soancă, Silviu Albu, Anda Gâta, Carmen Silvia Caloian, Andreea Cândea   +7 more
doaj   +1 more source

Early stages of tooth development in the harbor porpoise Phocoena phocoena

The Anatomical Record, EarlyView.
Abstract Here we describe the stages of tooth development in toothed whales on the basis of the harbor porpoise (Phocoena phocoena). The aim of the study was to find out whether these stages are identical to those of other mammals analyzed so far although toothed whales are homodont and monophyodont.
Lasse M. Mathes, Lennart Müller‐Thomsen, Stefan Huggenberger   +2 more
wiley   +1 more source

A novel toothbrush with a thin-head, slender-neck and super-tapered bristles enhancing accessibility in hard-to-reach areas: a crossover randomized trial

BMC Oral Health
Background Toothbrushing is the most commonly used method to physically remove dental plaque. However, there are many areas of the mouth that are difficult to reach with a toothbrush.
Hyo-Jung Kim, Joo-Yeon Lee, Eun-Song Lee, Da-Mi Kim, Ui-Won Jung, Jae-Kook Cha, Baek-Il Kim   +6 more
doaj   +1 more source