Results 121 to 130 of about 287,339 (268)

Targeting G3BP1 Condensate Topology Promotes Stress Granule Assembly via m6A‐IGF2BP1 for Ischemic Stroke Rescue

Advanced Science, EarlyView.
Our research reveals that small‐molecule icariin (ICA) directly binds Ras‐GTPase‐activating protein SH3 domain‐binding protein 1 (G3BP1), inducing conformational change and oligomerization. This interaction confers neuroprotection by recruiting insulin‐like growth factor 2 mRNA‐binding protein 1 (IGF2BP1) and modulating N6‐methyladenosine (m6A ...
Ling Li, Yong‐Dong Guo, Xiao‐Wen Zhang, Zhi‐Yong Du, Yu‐Qi Wang, Zhuo Yang, Qian‐Wei Luo, Fang‐Fang Zhuo, Tian‐Tian Wei, Zheng‐Ping Liu, Bo Han, Wei Yu, Pei‐Pei Zhang, Wei Zhou, Zhi‐Yuan Lu, Peng‐Fei Tu, Chun‐Hong Zheng, Ke‐Wu Zeng   +17 more
wiley   +1 more source

Worth an Arm and a Leg: The Critical Importance of Limb Ischemia

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Javier A. Valle, Stephen W. Waldo
doaj   +1 more source

An Update on Methods for Revascularization and Expansion of the TASC Lesion Classification to Include Below-the-Knee Arteries: A Supplement to the Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II)

, 2015
Michael R. Jaff, Christopher J. White, William R. Hiatt, Gerry Fowkes, John Dormandy, Mahmood K. Razavi, Jim A. Reekers, Lars Norgren   +7 more
openalex   +2 more sources

Monocyte‐Differentiation‐Activated Fluorescent “Scout” Probe for Precise in Vivo Detection of Vulnerable Plaque

Advanced Science, EarlyView.
An innovative monocyte‐differentiation‐activated fluorescent “scout” probe (MDAF) leverages the inherent chemotaxis of monocytes toward vulnerable plaques (VAP) to enable efficient targeted delivery while achieving spatiotemporally controllable activation of its AIE fluorescent signals with the dynamic differentiation of monocytes, providing an ...
Zechuan Li, Jiankai Dong, Zhengkun Liu, Chaoke Zhang, Jisen Li, Ying Tao, Ding Yang, Yansong Liu, Haoting Chen, Lu Liu, Jingsen Ji, Feng Cao, Dan Ding, Qian Liu, Chenxing Fu, Weisheng Guo   +15 more
wiley   +1 more source

Lower Extremity Peripheral Artery Disease and Quality of Life Among Older Individuals in the Community

, 2020
Aozhou Wu, Josef Coresh, Elizabeth Selvin, Hirofumi Tanaka, Gerardo Heiss, Alan T. Hirsch, Bernard G. Jaar, Kunihiro Matsushita   +7 more
openalex   +1 more source

Brd4 BD1 Domain Antagonism of MS436 Preserves Blood‐Brain Barrier Integrity via Rnf43/β‐Catenin Signaling Pathway

Advanced Science, EarlyView.
MS436 competitively binds to the BD1 domain of Brd4, thereby suppressing Brd4 induced degradation of tight junction proteins via the Rnf43‐Fzd4‐β‐catenin signaling pathway. Consequently, this attenuation of degradation reduces blood‐brain barrier leakage, leading to an improved overall prognosis after stroke.
Chenxiao Li, Xiaochen Zhang, Jiangwei Xia, Shuang Liu, Yushan Du, Sihan Li, Shukui Zhang, Yong Zhang, Fen Ji, Jianwei Jiao, Jingjing Zhang   +10 more
wiley   +1 more source

Metabolic biomarker discovery for risk of peripheral artery disease compared with coronary artery disease:lipoprotein and metabolite profiling of 31 657 individuals from 5 prospective cohorts

, 2021
Emmi Tikkanen, Vilma Jägerroos, Michael V. Holmes, Naveed Sattar, Mika Ala‐Korpela, Pekka Jousilahti, Annamari Lundqvist, Markus Perola, Veikko Salomaa, Peter Würtz   +9 more
openalex   +1 more source

The 2016 AHA/ACC Guideline on the Management of Patients with Lower Extremity Peripheral Artery Disease: An interview with SVM members of the writing committee [PDF]

, 2017
Ehrin J. Armstrong, Heather L. Gornik, Naomi M. Hamburg, Scott Kinlay   +3 more
openalex   +1 more source

Endothelial Cell‐Specific Molecule‐1 (ESM1): An Endogenous Anticoagulant and Protective Factor in Venous Thrombosis

Advanced Science, EarlyView.
This study identifies ESM1 as an endogenous anticoagulant that modulates venous thrombosis. It shows that ESM1 deficiency triggers vascular occlusion in zebrafish and mice, whereas its restoration or overexpression prolongs clot‐formation time. Mechanistic analyses reveal that ESM1 activates HCII through its dermatan‐sulfate chain, uncovering a ...
Changsheng Chen, Xiaojuan Ge, Dongxu Fu, Haijun Mei, Feng Lv, Chao Yang, Jiahao Lu, Xiaozhong Shen, Bowen Li, Xiaoning Wang, Dong Liu   +10 more
wiley   +1 more source

Novel Evaluation Method for Lower Extremity Peripheral Artery Disease With Duplex Ultrasound　― Usefulness of Acceleration Time ―

, 2020
Takeshi Yagyu, Sayaka Funabashi, Shuichi Yoneda, Teruo Noguchi, Satoshi Yasuda   +4 more
openalex   +2 more sources