Results 31 to 40 of about 1,348,336 (267)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Association of lipid levels, adipokines and multiple myeloma: a two-sample multivariate Mendelian randomization study

Scientific Reports
Many observational studies and experiments have found a strong association between lipid levels and adipokines and multiple myeloma (MM), but the causal relationship between lipid levels, adipokines and MM remains to be determined.
Yi Ding, Yudong Zhang, Xiaoshan Zhang, Mingrong Shang, Fan Dong   +4 more
doaj   +1 more source

Association Between FeNO, Total Blood IgE, Peripheral Blood Eosinophil and Inflammatory Cytokines in Partly Controlled Asthma

Journal of Asthma and Allergy, 2020
Ahmed Badar,1 Ayad Mohammed Salem,1 Abdullah Omar Bamosa,1 Hatem Othman Qutub,2 Rakesh Kumar Gupta,2 Intisar Ahmad Siddiqui3 1Department of Physiology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; 2Department of ...
Badar A, Salem AM, Bamosa AO, Qutub HO, Gupta RK, Siddiqui IA   +5 more
doaj  

Distribution characteristics of cells in splenomegaly due to hepatitis B-related cirrhotic portal hypertension and their clinical importance

Journal of International Medical Research, 2018
Objectives To investigate peripheral cytopenia in patients with splenomegaly due to hepatitis B-related cirrhotic portal hypertension (HBRCPH) by comparing blood cell counts from enlarged spleens with peripheral blood.
Xiaoyu Han, Yunfu Lv, Yejuan Li, Jie Deng, Qingan Qiu, Ning Liu, Shuya Zhao, Caixian Liao   +7 more
doaj   +1 more source

Tissue Trafficking Kinetics of Rhesus Macaque Natural Killer Cells Measured by Serial Intravascular Staining

Frontiers in Immunology, 2022
The in vivo tissue distribution and trafficking patterns of natural killer (NK) cells remain understudied. Animal models can help bridge the gap, and rhesus macaque (RM) primates faithfully recapitulate key elements of human NK cell biology.
Ryland D. Mortlock, Chuanfeng Wu, E. Lake Potter, Diana M. Abraham, David S. J. Allan, So Gun Hong, Mario Roederer, Cynthia E. Dunbar   +7 more
doaj   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Cellular and molecular screening of connective tissue dysplasia in adolescent athletes (pilot study)

Бюллетень сибирской медицины, 2018
The purpose of the study is to evaluate the cellular and molecular parameters of bone remodeling in the blood as potential markers of undifferentiated forms of connective tissue dysplasiaMaterials and methods.
M. V. Dvornichenko, A. E. Sizikova, T. V. Saprina, E. N. Pashkova, M. S. Shcherbinko, I. A. Khlusov, V. V. Novitsky   +6 more
doaj   +1 more source

CCL2, CCL8, CXCL12 chemokines in resectable non-small cell lung cancer (NSCLC)

Biomedical Papers, 2023
Background. Complex networks of chemokines are part of the immune reaction targeted against tumor cells. Chemokines influence cancer growth. It is unclear whether the concentrations of chemokines at the time of NSCLC (non-small cell lung cancer ...
Marie Drosslerova, Martina Sterclova, Alice Taskova, Vladislav Hytych, Eva Richterova, Magdalena Bruzova, Miloslav Spunda, Martin Komarc, Martina Koziar Vasakova   +8 more
doaj   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Dose dependence of the intensity of free radical processes in the peripheral blood of conditionally healthy donors

Ядерна фізика та енергетика, 2019
The nature of the dependence of the intensity of free radical processes in the peripheral blood of donors on the dose of radiation in vitro (0.5 - 3.0 Gy) related to the parameters of the prooxidant-antioxidant ratio (PAR) and the content of malonic ...
L. I. Makovetska, E. A. Domina, M. O. Druzhуna, O. V. Muliarchuk   +3 more
doaj   +1 more source