Results 121 to 130 of about 4,841,252 (345)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

CHROMOSOMAL ABERRATIONS AND MICRONUCLEI IN LYMPHOCYTES OF MEDICAL RADIATION WORKERS EXPOSED TO LONIZING RADIATION BELOW DOSE LIMIT [PDF]

Cell Journal, 2001
Introduction: Ionizing radiation induces various kinds of DNA damage in which may lead to chromosomal aberrations (CA). Inspite of growing importance in the risk assessment, the dose yield kinetics of CA and their implications for dose assessment are not
MOZDARANI H, GOURABI H
doaj  

Peripheral blood T Regulatory cell counts may not predict transplant rejection

BMC Immunology, 2010
Background Recent evidence shows that allograft survival rates show a positive correlation with the number of circulating T regulatory cells (Tregs). This study investigated both the number and the cytokine profiles exhibited by Foxp3+ Tregs in blood ...
Feng Li, Zhang Jie, Zhang Chuntao, Shan Juan, Huang Yuchuan, Li Shengfu, Li Youping   +6 more
doaj   +1 more source

Patterns of CT lung injury and toxicity after stereotactic radiotherapy delivered with helical tomotherapy in early stage medically inoperable NSCLC [PDF]

, 2015
To evaluate toxicity and patterns of radiologic lung injury on CT images after hypofractionated image-guided stereotactic body radiotherapy (SBRT) delivered with helical tomotherapy (HT) in medically early stage inoperable non-small-cell lung cancer ...
Agolli, Linda, Arcangeli, S, Bracci, S, Dognini, Jessica, Donato, Vittorio, Lopergolo, M. G, Migliorino, M. R, Monaco, Alessia, Portalone, L, Pressello, M. C   +9 more
core   +1 more source

Accelerated peripheral dose calculation for radiotherapy

, 2021
La radiothérapie représente l'un des principaux traitements dont bénéficient les patients atteints par un cancer. Elle n'est toutefois pas sans risque~: les rayonnements ionisants utilisés pour détruire la tumeur peuvent favoriser l'apparition d'effets secondaires à long terme lorsqu'ils atteignent des régions éloignées de la zone traitée.
openaire   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Construction of In vitro Dose-response Curve for Human Peripheral Blood Exposed to High-energy Clinical 6 MV X-rays

Medical Journal of Dr. D.Y. Patil Vidyapeeth
Introduction High-energy LINAC X-rays are used instead of the traditional modality (γ-rays) in cancer radiotherapy. Health professionals may be exposed to these high-energy X-rays owing to mishandling or mechanical failure, and using a low-energy X-rays ...
Vishakh Radhakrishna, Suchetha Kumari Nalilu, Tamizh Selvan Gnanasekaran   +2 more
doaj   +1 more source

IL-2 Therapy Diminishes Renal Inflammation and the Activity of Kidney-Infiltrating CD4+ T Cells in Murine Lupus Nephritis [PDF]

, 2019
An acquired deficiency of interleukin-2 (IL-2) and related disturbances in regulatory T cell (Treg) homeostasis play an important role in the pathogenesis of systemic lupus erythematosus (SLE).
Burmester, Gerd-Rüdiger, Enghard, Philipp, Humrich, Jens, Kloke, Lutz, Kühl, Anja, Riemekasten, Gabriela, Rose, Angelika, von Spee-Mayer, Caroline, Wu, Kaiyin   +8 more
core   +2 more sources

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source