Results 41 to 50 of about 638,015 (306)

Health-related quality of life in patients with peripheral nerve tumors: results from the German multicentric Peripheral Nerve Tumor Registry

Frontiers in Oncology
ObjectivePeripheral nerve tumors (PNTs) are rare diseases. So far, no multicenter data on diagnostics, the efficacy of treatment, long-term outcomes, and health-related quality of life (HRQoL) exist.
Nadja Grübel, Gregor Antoniadis, Uerschels AK, Benjamin Mayer, Ralph König, Christian Rainer Wirtz, Andrej Pala, Nora F. Dengler, Maria Teresa Pedro   +8 more
doaj   +1 more source

Development and training of a machine learning algorithm to identify patients at risk for recurrence following an arthroscopic Bankart repair (CLEARER): protocol for a retrospective, multicentre, cohort study

BMJ Open, 2022
Introduction Shoulder instability is a common injury, with a reported incidence of 23.9 per 100 000 person-years. There is still an ongoing debate on the most effective treatment strategy.
, S Nakagawa, L Rossi, Michel P J van den Bekerom, H Nakamura, A Lin, M Gotoh, Y V Kleinlugtenbelt, M Loppini, Job N Doornberg, P MacDonald, Laurent Lafosse, A Stone, Sanne H van Spanning, Lukas P E Verweij, Laurens J H Allaart, Laurent A M Hendrickx, George S Athwal, Thibault Lafosse, Geert Alexander Buijze, T Flinkillä, B R Waterman, B Owens, I Pasqualini, M Scheibel, M Minkus, J S Shaha, M A Ruiz Ibán, R T Li, J M Woodmass, J Phadnis, C Hatrick, T P van Iersel   +32 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Intraoperative 3D Navigation‐Guided Resection of Enlarged Transverse Process for Treating Bertolotti Syndrome Unresponsive to Noninvasive Treatments: Case Report

Clinical Case Reports
Bertolotti syndrome is a lumbosacral anomaly that induces persistent lumbar pain. This case describes 3D navigation‐guided resection of an enlarged transverse process.
Jakub Jankowski, Marcin Glin, Natalia Maślanek, Wiktoria Chyra, Agnieszka Pawełczyk, Maciej Radek   +5 more
doaj   +1 more source

Biceps lasso loop and self-locking tenodesis alongside repair of rotator cuff tears: randomised controlled trial study protocol (BLAST 1)

BMJ Open
Introduction Pathology of the long head of the biceps tendon (LHBT) frequently accompanies rotator cuff tears, with tenotomy and tenodesis often being used to address this pathology. While meta-analyses report comparable functional outcomes between these
Michel P J van den Bekerom, Thibault Lafosse, Geert Alexander Buijze, Igor J Shirinskiy, Dries Boulidam, Arno A Macken   +5 more
doaj   +1 more source

Multipotent vascular stem cells contribute to neurovascular regeneration of peripheral nerve. [PDF]

, 2019
BackgroundNeurovascular unit restoration is crucial for nerve regeneration, especially in critical gaps of injured peripheral nerve. Multipotent vascular stem cells (MVSCs) harvested from an adult blood vessel are involved in vascular remodeling; however,
Hsueh, Yuan-Yu, Huang, Ching-Wen, Huang, Wen-Chin, Li, Song, Patel, Shyam   +4 more
core  

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Using the main elbow flexion skin crease as an intraoperative parameter to determine the degree of exorotation needed for humeral derotational osteotomies in upper-type brachial plexus patients

Journal of Orthopaedic Surgery, 2018
Even though one of the surgical techniques most frequently used to correct external rotation deformity of the shoulder in brachial plexus patients is a humeral derotational osteotomy, few intraoperative parameters has yet been identified to determine the
Flavio César Ivalde, Gustavo Nizzo Miguens, Mariano Socolovsky   +2 more
doaj   +1 more source

Rapid Isolation of Dorsal Root Ganglion Macrophages. [PDF]

, 2019
There are growing interests to study the molecular and cellular interactions among immune cells and sensory neurons in the dorsal root ganglia after peripheral nerve injury.
Guan, Zhonghui, Leff, Jacqueline, Yu, Xiaobing   +2 more
core  

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source