Results 61 to 70 of about 148,079 (169)

Exosomes and Their MicroRNA Cargo: New Players in Peripheral Nerve Regeneration

Neurorehabilitation and Neural Repair, 2018
Peripheral nerve injury is a major clinical problem and often results in a poor functional recovery. Despite obvious clinical need, treatment strategies have been largely suboptimal.
Li-ming Qing, Huanwen Chen, Ju-yu Tang, X. Jia   +3 more
semanticscholar   +1 more source

Recent perspectives on the synergy of mesenchymal stem cells with micro/nano strategies in peripheral nerve regeneration-a review

Frontiers in Bioengineering and Biotechnology
Despite the intrinsic repair of peripheral nerve injury (PNI), it is important to carefully monitor the process of peripheral nerve repair, as peripheral nerve regeneration is slow and incomplete in large traumatic lesions. Hence, mesenchymal stem cells (
Majid Sharifi, Majid Sharifi, Majid Sharifi, Mohammad Kamalabadi-Farahani, Mohammad Kamalabadi-Farahani, Majid Salehi, Majid Salehi, Majid Salehi, Somayeh Ebrahimi-Brough, Morteza Alizadeh   +9 more
doaj   +1 more source

Improving the glial differentiation of human Schwann-like adipose-derived stem cells with graphene oxide substrates [PDF]

arXiv, 2017
There is urgent clinical need to improve the clinical outcome of peripheral nerve injury. Many efforts are directed towards the fabrication of bioengineered conduits, which could deliver stem cells to the site of injury to promote and guide peripheral nerve regeneration.
arxiv  

The Role of BDNF in Peripheral Nerve Regeneration: Activity-Dependent Treatments and Val66Met

Frontiers in Cellular Neuroscience, 2019
Despite the ability of peripheral nerves to spontaneously regenerate after injury, recovery is generally very poor. The neurotrophins have emerged as an important modulator of axon regeneration, particularly brain derived neurotrophic factor (BDNF). BDNF
Claire McGregor, A. English
semanticscholar   +1 more source

Electrical aligned polyurethane nerve guidance conduit modulates macrophage polarization and facilitates immunoregulatory peripheral nerve regeneration

Journal of Nanobiotechnology
Biomaterials can modulate the local immune microenvironments to promote peripheral nerve regeneration. Inspired by the spatial orderly distribution and endogenous electric field of nerve fibers, we aimed to investigate the synergistic effects of ...
Yiting Sun, Yinglong Zhang, Yibo Guo, Dongming He, Wanlin Xu, Wei Fang, Chenping Zhang, Yi Zuo, Zhen Zhang   +8 more
doaj   +1 more source

Investigation for the correlation between brain injury and injured ipsilateral sciatic nerve regeneration in a rat model

Journal of Integrative Neuroscience, 2019
Previous studies showed that brain trauma promotes repair of peripheral nerve injury by reducing scar in nerve endings. The effect of brain injury at different locations on ipsilateral rat sciatic nerve regeneration in Sprague-Dawley rats was found to ...
Haoqi Wang, Jianjun Ma, Xinze He, Qiang Xie, Yuting Fu, Pei Wang   +5 more
doaj   +1 more source

Model-based geometrical optimisation and in vivo validation of a spatially selective multielectrode cuff array for vagus nerve neuromodulation [PDF]

, 2019
Background. Neuromodulation by electrical stimulation of the human cervical vagus nerve may be limited by adverse side effects due to stimulation of off-target organs. It may be possible to overcome this by spatially selective stimulation of peripheral nerves.
arxiv   +1 more source

Neural crest derived stem cells from dental pulp and tooth-associated stem cells for peripheral nerve regeneration

Neural Regeneration Research, 2019
The peripheral nerve injuries, representing some of the most common types of traumatic lesions affecting the nervous system, are highly invalidating for the patients besides being a huge social burden.
A. Pisciotta, L. Bertoni, Antonio Vallarola, Giulia Bertani, D. Mecugni, G. Carnevale   +5 more
semanticscholar   +1 more source

Migrating Schwann cells direct axon regeneration within the peripheral nerve bridge

Glia, 2020
Schwann cells within the peripheral nervous system possess a remarkable regenerative potential. Current research shows that peripheral nerve‐associated Schwann cells possess the capacity to promote repair of multiple tissues including peripheral nerve ...
Qing Min, D. Parkinson, X. Dun
semanticscholar   +1 more source

In vivo interactions between tungsten microneedles and peripheral nerves [PDF]

Medical Engineering & Physics, Volume 34, Issue 6, July 2012, Pages 747-755, 2013
Tungsten microneedles are currently used to insert neural electrodes into living peripheral nerves. However, the biomechanics underlying these procedures is not yet well characterized. For this reason, the aim of this work was to model the interactions between these microneedles and living peripheral nerves.
arxiv