Effect of mechanical insufflation-exsufflation for ineffective cough on weaning duration in diseases of the peripheral or central nervous system (MEDINE): study protocol for a randomised controlled trial in a neurological weaning centre [PDF]
, 2023 Alexander Seipp +6 more
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Advances in Symbiotic Bioabsorbable Devices
Advanced Science, EarlyView.This review focuses on recent advances in bioabsorbable devices. This review concludes innovation at the material, device, and system levels, the significant advances toward biomedical applications. This review discusses and highlights the challenges and trends in symbiotic bioresorbable electronics, and provides a new direction for the development of ...
Chang Zhu +3 more
wiley +1 more source
Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease [PDF]
, 2000 Frédérique Bard +22 more
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The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges
Advanced Science, EarlyView.This paper summarizes the potential of biomaterials, stem cells, and gene editing technologies in the regeneration of inner ear hair cells, spiral ganglion neurons, and inner ear organoids. Challenges and potential developments are discussed and explored.
Zhe Li +3 more
wiley +1 more source
Advanced Science, EarlyView.By investigating auditory hyperexcitability in a mouse model for hereditary deafness, this study identified a subpopulation of afferent neurons of the auditory nerve marked by Otogl expression. Despite their apparently normal hearing, Otogl+/− mice display poor activation of afferent neurons processing loud sounds and an elevation of the middle the ear
Mathilde Gagliardini +24 more
wiley +1 more source
How Histone Deacetylases Control Myelination [PDF]
, 2018 Myelinated axons are a beautiful example of symbiotic interactions between two cell types: Myelinating glial cells organize axonal membranes and build their myelin sheaths to allow fast action potential conduction, while axons regulate myelination and ...
Jacob, Claire +2 more
core
Advanced Science, EarlyView.Schematic diagram of the working model of TRAF3IP3 in the coordination of ER stress and autophagy related apoptosis in lung cancer cells. Abstract TNF receptor‐associated factor 3 interacting protein 3 (TRAF3IP3/T3JAM) exhibits dual roles in cancer progression. While upregulated in most malignancies and critical for immune regulation.
Guang Zhao +11 more
wiley +1 more source
Synergizing Large Language Models and Task-specific Models for Time Series Anomaly Detection [PDF]
arXivIn anomaly detection, methods based on large language models (LLMs) can incorporate expert knowledge by reading professional document, while task-specific small models excel at extracting normal data patterns and detecting value fluctuations from training data of target applications.
arxiv
Damage of cutaneous peripheral nervous system evolves differently according to the disease phase and subset of systemic sclerosis [PDF]
, 2005 L. Ibba Manneschi +8 more
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