Results 201 to 210 of about 297,361 (266)

Targeting Histamine H4 Receptor in the Rostral Ventromedial Medulla to Relieve Hypertension

Advanced Science, EarlyView.
H4R and its downstream TRPV1 channel mediate the excitatory effect of TMN histaminergic afferent inputs on GABAergic sympathoinhibitory neurons in RVMM. Intranasal delivery of selective H4R agonist VUF 8430 suppresses renal sympathetic outflow and elicits sustained depressor and bradycardia responses in SHRs and CUMS‐induced hypertensive rats ...
Ying Shi, Yang‐Xun Zhang, Jun‐Yi Chen, Sai Ma, Wei‐Xuan Xue, Wei Li, Qian‐Xiao Li, Bo Song, Ya‐Ting Li, Hong‐Yu Ma, Shu‐Tao Xie, Hong‐Zhao Li, Di‐Jun Chen, Qi‐Peng Zhang, Hui‐Jie Ma, Jian‐Jun Wang, Lei Yu, Xiao‐Yang Zhang, Jing‐Ning Zhu   +18 more
wiley   +1 more source

3D Bioprinted Neural Tissues: Emerging Strategies for Regeneration and Disease Modeling. [PDF]

Pharmaceutics
Choi T, Park J, Lee S, Jeon HJ, Kim BH, Kim HO, Lee H.   +6 more
europepmc   +1 more source

Allele‐Specific Regulation of PAXIP1‐AS1 by SMC3/CEBPB at rs112651172 in Psychiatric Disorders Drives Synaptic and Behavioral Dysfunctions in Mice

Advanced Science, EarlyView.
This study identifies a functional noncoding variant, rs112651172 (C/G), that drives allele‐specific expression of PAXIP1‐AS1 in monozygotic twin pairs discordant for schizophrenia and bipolar disorder. The risk G allele enhances CEBPB binding, leading to lncRNA upregulation, CNTNAP3 derepression, and synaptic and behavioral deficits in mice.
Chaoying Ni, He Chen, Qiaqi Chen, Yangyang Liao, Yunqian Wang, Linyan Ye, Xiaohui Wu, Hongyu Ni, Tingyun Jiang, Shufen Li, Qiong Yang, Hong Xue, Zhongju Wang, Feng Yi, Cunyou Zhao   +14 more
wiley   +1 more source

<i>Akkermansia muciniphila</i> in neurological disorders: mechanisms and therapeutic potential via the gut-brain axis. [PDF]

Front Neurosci
Feng J, Hu X, Liu J, Wang W, Chen L, Pang R, Zhang A.   +6 more
europepmc   +1 more source

A Rare Case of Brain Biopsy-confirmed Neurolymphomatosis Involving the Central Nervous System Mimicking Polyneuropathy as a Complication of Refractory Sjögren's Syndrome. [PDF]

NMC Case Rep J
Okamura Y, Nagashima H, Tanaka K, Chihara N, Sekiguchi K, Matsumoto R, Sasayama T.   +6 more
europepmc   +1 more source

Central nervous system superficial siderosis: A case report and literature review. [PDF]

Medicine (Baltimore)
Xu Q, Wen S, Li H, Yang G, Di M.
europepmc   +1 more source

The dual nature of neuroinflammation in networked brain. [PDF]

Front Immunol
Müller L, Di Benedetto S, Müller V.
europepmc   +1 more source

Parkinson's disease beyond the brain: implications for treatments. [PDF]

Front Aging Neurosci
Malekian Naeini S, Lopez MD, Fraser PE, Tandon A.   +3 more
europepmc   +1 more source