Advanced Science, EarlyView.This study shows that gene replacement therapy using the AAV2/Anc80L65 virus can successfully restore hearing and balance in Ush1c knockout mice. The treatment leads to lasting improvements in both auditory and vestibular functions, highlighting its potential as a therapeutic approach for genetic hearing loss and vestibular disorders in humans ...
Weinan Du +13 more
wiley +1 more source
Biological Role of Dystroglycan in Schwann Cell Function and Its Implications in Peripheral Nervous System Diseases [PDF]
, 2010 Toshihiro Masaki, Kiichiro Matsumura
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Advanced Science, EarlyView.sEVs have a critical role in orchestrating interorgan crosstalk and mediating exercise‐induced therapeutic effects. Lin et al. demonstrates that sEVs miR‐17/20a‐5p mediates the muscle‐brain crosstalk and emphasizes the central role of mTOR signaling in executing molecular programs that can protect brain health in response to exercise. Abstract Physical
Huawei Lin +21 more
wiley +1 more source
Advances in Symbiotic Bioabsorbable Devices
Advanced Science, EarlyView.This review focuses on recent advances in bioabsorbable devices. This review concludes innovation at the material, device, and system levels, the significant advances toward biomedical applications. This review discusses and highlights the challenges and trends in symbiotic bioresorbable electronics, and provides a new direction for the development of ...
Chang Zhu +3 more
wiley +1 more source
The effect of mild traumatic brain injury on peripheral nervous system pathology in wild-type mice and the G93A mutant mouse model of motor neuron disease [PDF]
, 2015 Teresa M. Evans +6 more
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Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy
Advanced Science, EarlyView.In ARHL, the stria vascularis, acting as a cochlear battery, gradually loses its ability to maintain the endocochlear potential, leading to impaired hair cell function and progressive hearing loss. Single‐cell sequencing reveals age‐related cellular changes in the cochlea, providing insights into the underlying mechanisms of aging and potential ...
Xiaoxu Zhao +12 more
wiley +1 more source
Clinical, electrophysiological, and biochemical markers of peripheral and central nervous system disease in canine globoid cell leukodystrophy (
, 2016 Allison M. Bradbury +9 more
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The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges
Advanced Science, EarlyView.This paper summarizes the potential of biomaterials, stem cells, and gene editing technologies in the regeneration of inner ear hair cells, spiral ganglion neurons, and inner ear organoids. Challenges and potential developments are discussed and explored.
Zhe Li +3 more
wiley +1 more source
Functional state of the peripheral nervous system in miners with vibration disease from the general vibration (by the data of electroneuromyography) [PDF]
, 2016 V.I. Chernyuk, O. M. Semeryak
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The use of nucleotides in diseases of the peripheral nervous system
, 2021 N.I. Fister, M.M. Oros
openalex +2 more sources