Starvation of Cancer via Induced Ketogenesis and Severe Hypoglycemia [PDF]
, 2014 Neoplasms are highly dependent on glucose as their substrate for energy production and are generally not able to catabolize other fuel sources such as ketones and fatty acids. Thus, removing access to glucose has the potential to starve cancer cells and induce apoptosis.
arxiv +1 more source
A Coupled Neural Circuit Design for Guillain-Barre Syndrome [PDF]
arXiv, 2022 Guillain-Barre syndrome is a rare neurological condition in which the human immune system attacks the peripheral nervous system. A peripheral nervous system appears as a diffusively connected system of mathematical models of neuron models, and the system's period becomes shorter than the periods of each neural circuit.
arxiv
Unresolved excess accumulation of myelin-derived cholesterol contributes to scar formation after spinal cord injury [PDF]
arXiv, 2022 Background: Spinal cord injury triggers complex pathological cascades, resulting in destructive tissue damage and incomplete tissue repair. Scar formation is generally considered as a barrier for regeneration in central nervous system (CNS), while the intrinsic mechanism of scar-forming after spinal cord injury has not been completed deciphered ...
arxiv
Optical coherence tomography imaging of evoked neural activity in sciatic nerve of rat [PDF]
, 2020 Significance: Imaging neural activity in myelinated tissue using optical coherence tomography (OCT) creates new possibilities for functional imaging in the peripheral and central nervous systems. Aim: To investigate changes in OCT images in response to evoked neural activity in sciatic nerve of rat in vitro.
arxiv +1 more source
Body schema or the body as its own best model [PDF]
in G. \v{S}ejnov\'a and M. Vavre\v{c}ka and J. Hvoreck\'y, ed.,
'Kognice a um\v{e}l\'y \v{z}ivot XX (Cognition and Artificial Life XX)', CTU
in Prague, , pp. 45-51 (2022), 2022 Rodney Brooks (1991) put forth the idea that during an agent's interaction with its environment, representations of the world often stand in the way. Instead, using the world as its own best model, i.e. interacting with it directly without making models, often leads to better and more natural behavior.
arxiv
Effect of beta-Dystroglycan Processing on Utrophin / DP116 Anchorage in Normal and MDX Mouse Schwann Cell Membrane [PDF]
Neuroscience 141 (18/04/2006) 607-620, 2007 In the peripheral nervous system, utrophin and the short dystrophin isoform (Dp116) are co-localized at the outermost layer of the myelin sheath of nerve fibers; together with the dystroglycan complex. In peripheral nerve, matrix metalloproteinase (MMP) creates a 30 kDa fragment of beta-dystroglycan, leading to a disruption of the link between the ...
arxiv +1 more source
Modeling the Neuromuscular Control System of an Octopus Arm [PDF]
arXiv, 2022 The octopus arm is a neuromechanical system that involves a complex interplay between peripheral nervous system (PNS) and arm musculature. This makes the arm capable of carrying out rich maneuvers. In this paper, we build a model for the PNS and integrate it with a muscular soft octopus arm.
arxiv
Visceral Machines: Risk-Aversion in Reinforcement Learning with Intrinsic Physiological Rewards [PDF]
arXiv, 2018 As people learn to navigate the world, autonomic nervous system (e.g., "fight or flight") responses provide intrinsic feedback about the potential consequence of action choices (e.g., becoming nervous when close to a cliff edge or driving fast around a bend.) Physiological changes are correlated with these biological preparations to protect one-self ...
arxiv
2D Multi-Class Model for Gray and White Matter Segmentation of the Cervical Spinal Cord at 7T [PDF]
arXiv, 2021 The spinal cord (SC), which conveys information between the brain and the peripheral nervous system, plays a key role in various neurological disorders such as multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS), in which both gray matter (GM) and white matter (WM) may be impaired.
arxiv
Identification of Key Proteins Involved in Axon Guidance Related Disorders: A Systems Biology Approach [PDF]
arXiv, 2018 Axon guidance is a crucial process for growth of the central and peripheral nervous systems. In this study, 3 axon guidance related disorders, namely- Duane Retraction Syndrome (DRS) , Horizontal Gaze Palsy with Progressive Scoliosis (HGPPS) and Congenital fibrosis of the extraocular muscles type 3 (CFEOM3) were studied using various Systems Biology ...
arxiv