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An experimental model for selective production of neoplasms of the peripheral nervous system
Ninety-three tumors of the peripheral nervous system (PNS) were produced in 30 male Fischer (CDF) rats following intravenous injection of 10 mg/kg of N-methyl N-nitrosourea (MNU) twice weekly for 9 weeks. The high susceptibility of CDF rats to an optimal dose of MNU provides a useful experimental model to study induction and pathogenesis of tumors of ...
James A. Swenberg+2 more
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Neoplasms of the Peripheral Nervous System
Neoplasms of the peripheral nervous system arise from the cellular sheath surrounding the nerve trunks, that is, the pluripotential Schwann cells and related cells, and rarely affect the feet. When present, they are most frequently associated with the autosomal dominantly inherited neurofibromatosis 1.
G K, Potter, J S, Feldman
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Many different types of small cell, embryonal, and poorly differentiated neoplasms originate within the central and peripheral nervous systems. Because appropriate treatment is based on a correct diagnosis, the surgical pathologist must be familiar both with basic characteristics of each of the numerous entities as well as the spectrum of morphologic ...
Hannes Vogel, Gregory N. Fuller
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Central and peripheral nervous system neoplasms
Derek C. Knottenbelt+2 more
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4 Cellular and Molecular Biology of Central Nervous System Spinal and Peripheral Nerve Neoplasms
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T-cell receptor V-gene usage in neoplasms of the central nervous system
Journal of Neurosurgery, 1993✓ The use of tumor-infiltrating lymphocytes in the treatment of central nervous system (CNS) neoplasms has met with serious obstacles due to difficulty of culture and poor characterization. Since in other tumors the therapeutic effects of tumor-infiltrating lymphocytes have been shown to rely on T-cell receptor engagement, the authors addressed the ...
Adrian Merlo+8 more
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