Results 11 to 20 of about 1,472,414 (411)

Chemotherapy-Induced Peripheral Neuropathy: Epidemiology, Pathomechanisms and Treatment

Oncology and Therapy, 2021
This review provides an update on the current clinical, epidemiological and pathophysiological evidence alongside the diagnostic, prevention and treatment approach to chemotherapy-induced peripheral neuropathy (CIPN).
J. Burgess, M. Ferdousi, D. Gosal, C. Boon, Kohei Matsumoto, A. Marshall, T. Mak, A. Marshall, B. Frank, R. Malik, U. Alam   +10 more
semanticscholar   +1 more source

Pathomechanisms of Paclitaxel-Induced Peripheral Neuropathy

Toxics, 2021
Peripheral neuropathy is one of the most common side effects of chemotherapy, affecting up to 60% of all cancer patients receiving chemotherapy. Moreover, paclitaxel induces neuropathy in up to 97% of all gynecological and urological cancer patients.
Ines Klein, H. Lehmann
semanticscholar   +1 more source

Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: ASCO Guideline Update.

Journal of Clinical Oncology, 2020
PURPOSE To update the ASCO guideline on the recommended prevention and treatment approaches in the management of chemotherapy-induced peripheral neuropathy (CIPN) in adult cancer survivors.
C. Loprinzi, C. Lacchetti, J. Bleeker, G. Cavaletti, C. Chauhan, D. Hertz, M. Kelley, A. Lavino, M. Lustberg, J. Paice, B. Schneider, Ellen M. Lavoie Smith, M. Smith, Thomas J. Smith, N. Wagner-Johnston, D. Hershman   +15 more
semanticscholar   +1 more source

Nerve and Vascular Biomarkers in Skin Biopsies Differentiate Painful From Painless Peripheral Neuropathy in Type 2 Diabetes

Frontiers in Pain Research, 2021
Painful diabetic peripheral neuropathy can be intractable with a major impact, yet the underlying pain mechanisms remain uncertain. A range of neuronal and vascular biomarkers was investigated in painful diabetic peripheral neuropathy (painful-DPN) and ...
Pallai Shillo, Yiangos Yiangou, Philippe Donatien, Marni Greig, Dinesh Selvarajah, Iain D. Wilkinson, Praveen Anand, Solomon Tesfaye   +7 more
doaj   +1 more source

The integrated stress response contributes to tRNA synthetase–associated peripheral neuropathy

Science, 2021
Description Defeating peripheral neuropathy The mechanisms underlying peripheral neuropathies are not well understood. Spaulding et al. studied mouse models of the inherited Charcot-Marie-Tooth (CMT) disease, which is caused by mutations in transfer RNA (
E. Spaulding, T. Hines, P. Bais, A. Tadenev, R. Schneider, D. Jewett, B. Pattavina, S. L. Pratt, K. H. Morelli, M. Stum, D. Hill, C. Gobet, M. Pipis, M. Reilly, M. Jennings, R. Horvath, Y. Bai, M. Shy, B. Alvarez-Castelao, E. Schuman, L. Bogdanik, E. Storkebaum, R. Burgess   +22 more
semanticscholar   +1 more source

tRNA overexpression rescues peripheral neuropathy caused by mutations in tRNA synthetase

Science, 2021
Description Defeating peripheral neuropathy The mechanisms underlying peripheral neuropathies are not well understood. Spaulding et al. studied mouse models of the inherited Charcot-Marie-Tooth (CMT) disease, which is caused by mutations in transfer RNA (
A. Zuko, M. Mallik, R. Thompson, E. Spaulding, Anne Wienand, Marije Been, A. Tadenev, N. van Bakel, Céline Sijlmans, Leonardo A. Santos, Julia Bussmann, Marica Catinozzi, Sarada Das, Divita Kulshrestha, R. Burgess, Z. Ignatova, E. Storkebaum   +16 more
semanticscholar   +1 more source

Dabrafenib Promotes Schwann Cell Differentiation by Inhibition of the MEK-ERK Pathway

Molecules, 2021
Schwann cell differentiation involves a dynamic interaction of signaling cascades. However, much remains to be elucidated regarding the function of signaling molecules that differ depending on the context in which the molecules are engaged.
Kyuhee Park, Yoonkyoung Shin, Gyeongbeen Lee, Hwantae Park, Yongmun Choi   +4 more
doaj   +1 more source

Pathological Mechanisms of Bortezomib-Induced Peripheral Neuropathy

International Journal of Molecular Sciences, 2021
Bortezomib, a first-generation proteasome inhibitor widely used in chemotherapy for hematologic malignancy, has effective anti-cancer activity but often causes severe peripheral neuropathy.
Shota Yamamoto, N. Egashira
semanticscholar   +1 more source

Inflammatory Mechanisms in the Pathophysiology of Diabetic Peripheral Neuropathy (DN)—New Aspects

International Journal of Molecular Sciences, 2021
The pathogenesis of diabetic neuropathy is complex, and various pathogenic pathways have been proposed. A better understanding of the pathophysiology is warranted for developing novel therapeutic strategies.
P. Baum, K. Toyka, M. Blüher, J. Kosacka, M. Nowicki   +4 more
semanticscholar   +1 more source

Trench Foot or Non-Freezing Cold Injury As a Painful Vaso-Neuropathy: Clinical and Skin Biopsy Assessments

Frontiers in Neurology, 2017
BackgroundTrench foot, or non-freezing cold injury (NFCI), results from cold exposure of sufficient severity and duration above freezing point, with consequent sensory and vascular abnormalities which may persist for years.
Praveen Anand, Rosario Privitera, Yiangos Yiangou, Philippe Donatien, Rolfe Birch, Peter Misra   +5 more
doaj   +1 more source