Results 21 to 30 of about 159,027 (267)

Disease mechanisms in hereditary sensory and autonomic neuropathies

Neurobiology of Disease, 2006
Inherited peripheral neuropathies are common monogenically inherited diseases of the peripheral nervous system. In the most common variant, i.e., the hereditary motor and sensory neuropathies, both motor and sensory nerves are affected.
Nathalie Verpoorten, Peter De Jonghe, Vincent Timmerman   +2 more
doaj   +1 more source

Natural agents mediated autophagic signal networks in cancer

Cancer Cell International, 2017
Recent studies suggested that natural compounds are important in finding targets for cancer treatments. Autophagy (“self-eating”) plays important roles in multiple diseases and acts as a tumor suppressor in cancer.
Eun Jung Sohn, Hwan Tae Park
doaj   +1 more source

Orphan Peripheral Neuropathies

Journal of Neuromuscular Diseases, 2020
Objectives: Generally, neuropathies of peripheral nerves are a frequent condition (prevalence 2–3%) and most frequently due to alcoholism, diabetes, renal insufficiency, malignancy, toxins, or drugs. However, the vast majority of neuropathies has orphan status.
Finsterer, Josef, Löscher, Wolfgang N., Wanschitz, Julia, Iglseder, Stefan   +3 more
openaire   +3 more sources

Plantar pressure distribution profile of type 2 diabetes mellitus with diabetic foot syndrome: A hospital-based observational study

Сахарный диабет, 2022
INTRODUCTION: The prevalence of diabetic foot syndrome is increasing in the Indian population. It is a triad of neurological, vascular, and biomechanical changes due to long term diabetes mellitus (DM).
H. Ya. Korada, E. Arora, Sh. K. Rao, M. Hande, S. Shetty, A. G. Maiya   +5 more
doaj   +1 more source

Association of serum calprotectin with peripheral neuropathy in patients with type 2 diabetes mellitus

Journal of Family Medicine and Primary Care, 2021
Introduction: Peripheral neuropathy is a common microvascular complication in patients with type 2 diabetes mellitus with a prevalence of around 50%. Objectives: This prospective observational cross-sectional study was done to assess serum calprotectin ...
Ramanathan Velayutham, Pradeep Pankajakshan Nair, Prashant S Adole, Vadivelan Mehalingam   +3 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Improvement of peripheral neuropathy in a patient with antineutrophil cytoplasmic antibody-negative eosinophilic granulomatosis with polyangiitis by additional mepolizumab

Allergy, Asthma & Clinical Immunology, 2022
Background Eosinophilic granulomatosis with polyangiitis (EGPA) is a vasculitis characterized by abnormally high eosinophils and frequent peripheral neuropathy.
Yoshiro Kai, Masanori Yoshikawa, Masayuki Matsuda, Kentaro Suzuki, Hiroya Ohara, Naohiko Iguchi, Takehito Kasamatsu, Kenji Uno, Nobuhiro Fujioka, Yukio Fujita, Shigeo Muro   +10 more
doaj   +1 more source

Changes in the central nervous system in diabetic neuropathy

Heliyon, 2023
One of the most common chronic complications arising from diabetes is diabetic peripheral neuropathy. Depending on research statistics, approximately half of the people who have diabetes will suffer from diabetic peripheral neuropathy over time, which ...
Yarui Zang, Dongqing Jiang, Xianghua Zhuang, Shihong Chen   +3 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Ageing‐Associated Dysregulation of Myogenic Differentiation in Inclusion Body Myositis

Journal of Cachexia, Sarcopenia and Muscle
Skeletal muscle is a postmitotic tissue dependent on a complex and tightly regulated regeneration process involving numerous intracellular and extracellular factors, including myogenic regulatory factors (MRFs), cytokines and myokines.
Geert M. deVries, Willem De Ridder, Jonathan Baets   +2 more
doaj   +1 more source