Results 11 to 20 of about 159,027 (267)

Peripheral neuropathy in thalassemia [PDF]

Annals of Saudi Medicine, 2006
Patients with thalassemia may complain of numbness and weakness of the lower extremities. The aim of the study was to document whether these patients suffer from a polyneuropathy and to determine any contributing factors for the development of neuropathy.We examined 30 patients with thalassemia major and intermedia, clinically and ...
Sawaya Raja, Zahed Laila, Taher Ali
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Propylthiouracil and peripheral neuropathy [PDF]

Arquivos de Neuro-Psiquiatria, 1992
Peripheral neuropathy is a rare manifestation in hyperthyroidism. We describe the neurological manifestations of a 38 year old female with Graves' disease who developed peripheral neuropathy in the course of her treatment with propylthiouracil. After the drug was tapered off, the neurological signs disappeared.
Boekel, Valentina Van, Godoy, José Maurício, Lamy, Luiz A., Assuf, Samira, Meyer Neto, João G. Corrêa, Balassiano, Salim L., Prata, Luiz E.   +6 more
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The UPR-PERK pathway is not a promising therapeutic target for mutant SOD1-induced ALS

Neurobiology of Disease, 2019
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease, characterized by motor neuron death in the brain and spinal cord.
Yulia Dzhashiashvili, Chase P. Monckton, Harini S. Shah, Rejani B. Kunjamma, Brian Popko   +4 more
doaj   +1 more source

Oligodendroglia-derived extracellular vesicles activate autophagy via LC3B/BAG3 to protect against oxidative stress with an enhanced effect for HSPB8 enriched vesicles

Cell Communication and Signaling, 2022
Background The contribution of native or modified oligodendroglia-derived extracellular vesicles (OL-EVs) in controlling chronic inflammation is poorly understood. In activated microglia, OL-EVs contribute to the removal of cytotoxic proteins following a
Bram Van den Broek, Charlotte Wuyts, Angela Sisto, Isabel Pintelon, Jean-Pierre Timmermans, Veerle Somers, Vincent Timmerman, Niels Hellings, Joy Irobi   +8 more
doaj   +1 more source

MicroRNA 200c-3p regulates autophagy via upregulation of endoplasmic reticulum stress in PC-3 cells

Cancer Cell International, 2018
Background Autophagy is a response to cellular and environmental conditions and facilitates cell survival. Here, we investigated the role of ectopic expression of microRNA (miRNA) 200c-3p in autophagy. Methods miRNA mimics were used to overexpress miRNAs.
Eun Jung Sohn
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Urinary acrolein protein conjugates-tocreatinine ratio is positively associated with diabetic peripheral neuropathy in patients with type 2 diabetes mellitus

Endocrine Connections, 2023
Acrolein, an unsaturated aldehyde, plays a pathological role in neurodegenerative diseases. However, less is known about its effects on peripheral neuropathy.
Tsung-Hui Wu, Guan-Yu Su, Tsung-Yun Liu, Hsiang-Tsui Wang, Chii-Min Hwu   +4 more
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HDAC6: A Key Link Between Mitochondria and Development of Peripheral Neuropathy

Frontiers in Molecular Neuroscience, 2021
Peripheral neuropathy, which is the result of nerve damage from lesions or disease, continues to be a major health concern due to the common manifestation of neuropathic pain. Most investigations into the development of peripheral neuropathy focus on key
Krystal English, Krystal English, Michelle Craig Barton, Michelle Craig Barton   +3 more
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The neuroinflammatory role of Schwann cells in disease

Neurobiology of Disease, 2013
Peripheral neuropathies are associated with a variety of clinical symptoms ranging from motor and sensory symptoms to autonomic dysfunction. The primary disease causes for peripheral nerve disorders are also very heterogeneous, including genetic causes ...
Elke Ydens, Guillaume Lornet, Veerle Smits, Sofie Goethals, Vincent Timmerman, Sophie Janssens   +5 more
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Early-Onset of Transthyretin Amyloidosis in a Young Afro-Caribbean Woman With Thr60Ala Mutation

JACC: Case Reports, 2020
Transthyretin amyloidosis involves the deposition of transthyretin amyloid fibrils in the body. We report an unusual case of a young Afro-Caribbean woman harboring a Thr60Ala mutation who presented with clinical signs of heart failure and polyneuropathy ...
Stormy C. Keppel, MD, Thomas H. Brannagan, III, MD, Stephen Helmke, RDCS, MPH, Jeffeny De Los Santos, MD, Leidy J. Gonzalez, MD, Raisy Fayerman, MD, Sergio Teruya, MD, Mathew S. Maurer, MD   +7 more
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Transcriptional Fingerprint of Hypomyelination in and () Mice

ASN Neuro, 2016
The transcriptional program that controls oligodendrocyte maturation and central nervous system (CNS) myelination has not been fully characterized. In this study, we use high-throughput RNA sequencing to analyze how the loss of a key transcription factor,
Joshua D. Aaker, Benayahu Elbaz, Yuwen Wu, Timothy J. Looney, Li Zhang, Bruce T. Lahn, Brian Popko   +6 more
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