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Neuropathy - gait changes in the diabetic foot [PDF]

, 2008
Motor neuropathy in patients with diabetes can lead to weakness in the muscles of the foot and lower leg, which in turn can lead to characteristic changes to the structure of the foot, such as an altered arch profile.
McIntosh, Caroline, Newton, Veronica
core   +3 more sources

Neuropathy - pain damage and the diabetic foot [PDF]

, 2008
Neuropathy, or the impairment of nerve structures and function, is a common complication in diabetes and affects up to one-third of patients. The most common manifestation is the loss of pain sensation and this can lead to unrecognised trauma injuries ...
Newton, Veronica
core   +4 more sources

Nutritional optic and peripheral neuropathy: a case report. [PDF]

, 2009
INTRODUCTION: The link between nutritional status and either optic or peripheral neuropathies is well established with tobacco, ethanol, deficiencies in thiamine, vitamin A, B12, B3 and B6 and protein-energy malnutrition all being causative.
Nightingale, LM, Laura M Nightingale, Paviour, DC, Dominic C Paviour   +3 more
core   +1 more source

Chemotherapy-induced peripheral neuropathy in cancer patients : a four-arm randomized trial on the effectiveness of electroacupuncture [PDF]

, 2013
Purpose. Chemotherapy-induced peripheral neuropathy (CIPN) is a common and dose-limiting side effect of cytostatic drugs. Since there are no proven therapeutic procedures against CIPN, we were interested to define the role of electroacupuncture (EA) from
Bartsch, Hans Helge, Schröder, Sven, Lüdtke, Rainer, Jaroslawski, K, Ludtke, R, Jaroslawski, Karin, Güthlin, Corina, Rostock, M, Bartsch, H H, Guethlin, C, Rostock, Matthias, Schröder, S   +11 more
core   +1 more source

Gait Variability and Kinematic Alterations in People with Diabetes Mellitus and Peripheral Neuropathy [PDF]

Background: People with diabetes and peripheral neuropathy have been reported to show alterations in lower limb joint function compared to healthy non-diabetic people.
Bowling, Frank
core   +3 more sources

Early diagnosis of neuropathy in leprosy: comparing diagnostic tests in a large prospective study (the INFIR Cohort Study) [PDF]

, 2008
BackgroundLeprosy is the most frequent treatable neuromuscular disease. Yet, every year, thousands of patients develop permanent peripheral nerve damage as a result of leprosy.
Wilder-Smith, Einar P, Pramila Barkataki, van Brakel, Wim H, van Brakel Wim H., Wim H van Brakel, Diana N J Lockwood, Einar P Wilder-Smith, Nicholls Peter G., Peter G Nicholls, Wilder-Smith Einar P., Nicholls, Peter G, Lockwood Diana N. J., Das Loretta, INFIR Study Group, Nicholls, Peter G., Lockwood, Diana N.J, Das, Loretta, Barkataki, Pramila, Barkataki Pramila, van Brakel, W.H., Loretta Das, Wilder-Smith, Einar P., Lockwood, Diana NJ   +22 more
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The UPR-PERK pathway is not a promising therapeutic target for mutant SOD1-induced ALS

Neurobiology of Disease, 2019
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease, characterized by motor neuron death in the brain and spinal cord.
Yulia Dzhashiashvili, Chase P. Monckton, Harini S. Shah, Rejani B. Kunjamma, Brian Popko   +4 more
doaj   +1 more source

Oligodendroglia-derived extracellular vesicles activate autophagy via LC3B/BAG3 to protect against oxidative stress with an enhanced effect for HSPB8 enriched vesicles

Cell Communication and Signaling, 2022
Background The contribution of native or modified oligodendroglia-derived extracellular vesicles (OL-EVs) in controlling chronic inflammation is poorly understood. In activated microglia, OL-EVs contribute to the removal of cytotoxic proteins following a
Bram Van den Broek, Charlotte Wuyts, Angela Sisto, Isabel Pintelon, Jean-Pierre Timmermans, Veerle Somers, Vincent Timmerman, Niels Hellings, Joy Irobi   +8 more
doaj   +1 more source

MicroRNA 200c-3p regulates autophagy via upregulation of endoplasmic reticulum stress in PC-3 cells

Cancer Cell International, 2018
Background Autophagy is a response to cellular and environmental conditions and facilitates cell survival. Here, we investigated the role of ectopic expression of microRNA (miRNA) 200c-3p in autophagy. Methods miRNA mimics were used to overexpress miRNAs.
Eun Jung Sohn
doaj   +1 more source

Urinary acrolein protein conjugates-tocreatinine ratio is positively associated with diabetic peripheral neuropathy in patients with type 2 diabetes mellitus

Endocrine Connections, 2023
Acrolein, an unsaturated aldehyde, plays a pathological role in neurodegenerative diseases. However, less is known about its effects on peripheral neuropathy.
Tsung-Hui Wu, Guan-Yu Su, Tsung-Yun Liu, Hsiang-Tsui Wang, Chii-Min Hwu   +4 more
doaj   +1 more source