Results 1 to 10 of about 11,303 (156)

Epimutation analysis reveals involvement of SLIT2/ROBO signaling pathway in painful diabetic neuropathy [PDF]

Human Genomics
Changes in gene function or expression caused by epigenetic modifications may play a role in painful diabetic neuropathy. Two independent cohorts of patients deeply phenotyped for painful diabetic neuropathy underwent whole genome DNA methylation data ...
Katarzyna Malgorzata Kwiatkowska, Paolo Garagnani, Francesca Ferraresi, Massimiliano Bonafé, Maria G. Bacalini, Claudia Sala, Gastone Castellani, Davide Gentilini, Luciano Calzari, Dan Ziegler, Monique M. Gerrits, Catharina G. Faber, Rayaz A. Malik, Margherita Marchi, Erika Salvi, Giuseppe Lauria, Chiara Pirazzini   +16 more
doaj   +2 more sources

Corneal Nerve Morphology in Painful Diabetic Neuropathy: A Meta-Analysis of In Vivo Confocal Microscopy Studies [PDF]

Biomedicines
Background/Objectives: Painful diabetic peripheral neuropathy (pDPN) significantly impacts quality of life, yet its diagnosis remains challenging due to reliance on subjective pain reports and limited objective biomarkers.
Prajna Vidyasagar, Scott F. Farrell, Luisa Holguin Colorado, Samantha Dando, Katie Edwards   +4 more
doaj   +2 more sources

Painful Diabetic Neuropathy: Sex-Specific Mechanisms and Differences from Animal Models to Clinical Outcomes [PDF]

Cells
Diabetes is a chronic and progressive disease associated with high blood glucose levels. Several co-morbidities arise from diabetes, the most common and severe one is diabetic neuropathy whose symptoms also include pain hypersensitivity. Currently, there
Emma Merlin, Chiara Salio, Francesco Ferrini   +2 more
doaj   +2 more sources

Clinical advances in painful and painless diabetic neuropathy [PDF]

Jichu yixue yu linchuang, 2023
Painful neuropathy is present in 13% to 35% of diabetic patients, and the reasons for the differential clinical manifestations of painful and painless diabetic neuropathy (DNP) in diabetic patients are unclear.
YU Zhuoying, YANG Jing, JIANG Ye, LI Min
doaj   +1 more source

Painful diabetic neuropathy [PDF]

BMJ, 2014
Diabetes is a worldwide epidemic, and associated neuropathy is its most costly and disabling complication. Given the rising prevalence of painful diabetic neuropathy, it is increasingly important that we understand the best ways to diagnose and treat this condition. Diagnostic tests in this field are evolving rapidly.
Amanda, Peltier, Stephen A, Goutman, Brian C, Callaghan   +2 more
  +6 more sources

Optimal Utility of H-Reflex RDD as a Biomarker of Spinal Disinhibition in Painful and Painless Diabetic Neuropathy

Diagnostics, 2021
Impaired rate-dependent depression of the Hoffman reflex (HRDD) is a potential biomarker of impaired spinal inhibition in patients with painful diabetic neuropathy.
Anne Worthington, Alise Kalteniece, Maryam Ferdousi, Luca D’Onofrio, Shaishav Dhage, Shazli Azmi, Clare Adamson, Shaheen Hamdy, Rayaz A. Malik, Nigel A. Calcutt, Andrew G. Marshall   +10 more
doaj   +1 more source

Impact of vitamin D level in diabetic people with peripheral neuropathy

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2021
Background Diabetes mellitus (DM) is a metabolic disease which is complicated by occurrence of diabetic peripheral neuropathy (DPN). Vitamin D deficiency contributes to the etiology and progression of type 2 DM and development of micro-vascular ...
Mohammad H. Assy, Nashwa A. Draz, Sabah E. Fathy, Mohammad G. Hamed   +3 more
doaj   +1 more source

The Benefits of Astaxanthin to Improve Pain Relief in Patients with Painful Diabetic Neuropathy: An Open-Label, Randomized Controlled Trial

Pharmaceutical Sciences and Research, 2021
Treatment of diabetic neuropathy is still carried out by providing symptomatic therapy, which only improves ± 50% of the total symptoms felt by patients, but does not tackle the underlying causes of the disease.
Rizaldy Taslim Pinzon, Mary Rose Angelina Budi Harsana   +1 more
doaj   +1 more source

Painful diabetic neuropathy [PDF]

Diabetologia, 2005
Pain is probably the most distressing symptom of diabetic neuropathy (1). The features of pain in diabetic neuropathy were clearly documented by Pavy (2), who observed, that it was of burning and unremitting quality often with a nocturnal exacerbation.
Tesfaye S, Kempler, Péter
openaire   +3 more sources

Altered pain processing in patients with type 1 and 2 diabetes: systematic review and meta-analysis of pain detection thresholds and pain modulation mechanisms

BMJ Open Diabetes Research & Care, 2020
The first signs of diabetic neuropathy typically result from small-diameter nerve fiber dysfunction. This review synthesized the evidence for small-diameter nerve fiber neuropathy measured via quantitative sensory testing (QST) in patients with diabetes ...
Eva Sierra-Silvestre, Mari Somerville
doaj   +1 more source