Results 31 to 40 of about 11,356 (208)

Diagnosis and rational treatment of painful diabetic peripheral neuropathy: an interdisciplinary expert consensus

Сахарный диабет, 2019
Diabetic peripheral neuropathy is a common chronic complication of diabetes mellitus, significantly impairing well-being, quality of life and functioning of patients.
Gagik R. Galstyan, Elena G. Starostina, Nikolay N. Yakhno, Irina V. Gurieva, Maxim V. Churyukanov, Igor A. Strokov, Alla Y. Tokmakova, Mikhail L. Kukushkin, Anatoly I. Martynov, Marina V. Shestakova   +9 more
doaj   +1 more source

Painful diabetic neuropathy: an update

Annals Of Neurosciences, 2011
Diabetes, a silent killer, is a leading cause of neuropathy. Around 50% of diabetic patients develop peripheral neuropathy in 25 years. Painful diabetic neuropathy manifests as burning, excruciating, stabbing or intractable type of pain or presents with tingling or numbness.
Kaur, Sharonjeet, Pandhi, Promila, Dutta, Pinaki   +2 more
openaire   +2 more sources

Clinical approach to the treatment of painful diabetic neuropathy

Therapeutic Advances in Endocrinology and Metabolism, 2011
Painful neuropathy is a common and often progressive complication of diabetes. Patients frequently report symptoms of tingling, burning, lancinating pain, hyperesthesia, and allodynia.
Alexandra Hovaguimian, Christopher H. Gibbons   +1 more
doaj   +1 more source

Pharmacological Modulation of Rate-Dependent Depression of the Spinal H-Reflex Predicts Therapeutic Efficacy against Painful Diabetic Neuropathy

Diagnostics, 2021
Impaired rate-dependent depression (RDD) of the spinal H-reflex occurs in diabetic rodents and a sub-set of patients with painful diabetic neuropathy. RDD is unaffected in animal models of painful neuropathy associated with peripheral pain mechanisms and
Corinne A. Lee-Kubli, XiaJun Zhou, Corinne G. Jolivalt, Nigel A. Calcutt   +3 more
doaj   +1 more source

Correlation of vitamin D and diabetic peripheral neuropathic pain: A cross-sectional study

Journal of International Medical Research
Objective Although ample evidence exists on the association between vitamin D deficiency and diabetic peripheral neuropathy, only a few studies have distinguished between painful and painless forms.
Caixia Yao, Li Wang, Hongman Zhang, Wenping Yang, Ying Zhong, Wenli Han, Ji Xu, Yan Chen, Ping Wang, Shoucheng Zhang   +9 more
doaj   +1 more source

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source

ANTINOCICIPTIVE EFFECT OF GINGER EXTRACT IN STREPTOZOTOCIN-INDUCED DIABETIC RATS [PDF]

Assiut Veterinary Medical Journal, 2012
Hyperalgesia is one of the major symptoms of diabetic neuropathy in diabetic patients. Streptozotocin (STZ)-induced diabetic rats display exaggerated hyperalgesic behavior in response to noxious stimuli, and the most commonly employed animal model aspect
M. ABDEL DAIM
doaj   +1 more source

Histidine Supplementation Stabilizes Hearing and Vision and Improves Growth in HARS1‐Related Autosomal Recessive Disorder Associated With Usher‐Like Symptoms

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Autosomal recessive HARS1‐related disorder (originally described as Usher syndrome type 3B) caused by a homozygous Y454S variant in the histidyl‐tRNA synthetase gene (HARS1) is characterized by progressive sensorineural hearing and vision loss and respiratory deterioration with risk for sudden death following febrile illnesses.
Victoria Mok Siu, Rosan Kenana, Rana Chakrabarti, Sarah D. P. Wilhelm, Joseph Andrews, Susan J. Leat, Christina Parker, Michael Miller, Leslie A. Nangle, Wendy McCaul, Ashfia Chowdhury, Natalie Hutchings, Ryan A. Adams, Lauren Guy, Mandy Rhody, Verena Juncal, Marisa I. Mendes, Desiree E. C. Smith, Gajja S. Salomons, Angelica A. Moresco, Daphne L. McCulloch, D. Holmes Morton, Ilka U. Heinemann, C. Anthony Rupar   +23 more
wiley   +1 more source

The EXPLAIN Study: Exploring Arthrogryposis Multiplex Congenita in Adults in Norway — A Description of Demographic, Medical, and Neurological Findings

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Arthrogryposis Multiplex Congenita (AMC) encompasses several hundred conditions with diverse genetic, pathophysiological, and clinical origins. The overarching EXPLAIN study explores underlying causes and implications of AMC and represents the largest clinical cohort of adults with AMC reported to date.
My Vuong Hermansen, Kristin Ørstavik, Unni Steen, Mathias Toft, Cathrine Brunborg, Lena Lande Wekre   +5 more
wiley   +1 more source

Diagnosing and managing diabetic somatic and autonomic neuropathy

Therapeutic Advances in Endocrinology and Metabolism, 2019
The diagnosis and management of diabetic neuropathy can be a major challenge. Late diagnosis contributes to significant morbidity in the form of painful diabetic neuropathy, foot ulceration, amputation, and increased mortality.
Shazli Azmi, Maryam Ferdousi, Alise Kalteniece, Hamad Al-Muhannadi, Abdulrahman Al-Mohamedi, Nebras H. Hadid, Salah Mahmoud, Harun A. Bhat, Hoda Y. A. Gad, Adnan Khan, Georgios Ponirakis, Ioannis N. Petropoulos, Uazman Alam, Rayaz A. Malik   +13 more
doaj   +1 more source